edelfosine has been researched along with Lymphoma in 11 studies
edelfosine: RN given refers to parent cpd
edelfosine : A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
1-octadecyl-2-methylglycero-3-phosphocholine : A glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.
Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.
| Excerpt | Relevance | Reference |
|---|---|---|
| "S49 mouse lymphoma cells undergo apoptosis in response to the ALP (alkyl-lysophospholipid) edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine), FasL (Fas ligand) and DNA damage." | 7.77 | Phosphoinositide phosphatase SHIP-1 regulates apoptosis induced by edelfosine, Fas ligation and DNA damage in mouse lymphoma cells. ( Alderliesten, MC; Divecha, N; Jones, DR; Klarenbeek, JB; van Blitterswijk, WJ; van der Luit, AH; van Lummel, M; Verheij, M; Zerp, S, 2011) |
| "This provided an increase in relative oral bioavailability of 1500% after a single oral administration of drug-loaded LNs, maintaining edelfosine plasma levels over 7 days in contrast to a single oral administration of edelfosine solution, which presented a relative oral bioavailability of 10%." | 5.38 | Complete inhibition of extranodal dissemination of lymphoma by edelfosine-loaded lipid nanoparticles. ( Blanco-Prieto, MJ; Campanero, MA; de la Iglesia-Vicente, J; Estella-Hermoso de Mendoza, A; Lana, H; Mollinedo, F; Villa-Pulgarin, JA, 2012) |
| "S49 mouse lymphoma cells undergo apoptosis in response to the ALP (alkyl-lysophospholipid) edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine), FasL (Fas ligand) and DNA damage." | 3.77 | Phosphoinositide phosphatase SHIP-1 regulates apoptosis induced by edelfosine, Fas ligation and DNA damage in mouse lymphoma cells. ( Alderliesten, MC; Divecha, N; Jones, DR; Klarenbeek, JB; van Blitterswijk, WJ; van der Luit, AH; van Lummel, M; Verheij, M; Zerp, S, 2011) |
| ", edelfosine, perifosine, erucylphosphocholine, and compound D-21805, as inducers of apoptosis in the mouse lymphoma cell line S49." | 3.74 | A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells. ( Klarenbeek, JB; Perrissoud, D; Solary, E; van Blitterswijk, WJ; van der Luit, AH; Verheij, M; Vink, SR, 2007) |
| " The APL prototype edelfosine was previously found to be endocytosed by S49 mouse lymphoma cells via lipid rafts." | 3.74 | Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells. ( Klarenbeek, JB; van Blitterswijk, WJ; van der Luit, AH; Verheij, M; Vink, SR, 2007) |
| "This provided an increase in relative oral bioavailability of 1500% after a single oral administration of drug-loaded LNs, maintaining edelfosine plasma levels over 7 days in contrast to a single oral administration of edelfosine solution, which presented a relative oral bioavailability of 10%." | 1.38 | Complete inhibition of extranodal dissemination of lymphoma by edelfosine-loaded lipid nanoparticles. ( Blanco-Prieto, MJ; Campanero, MA; de la Iglesia-Vicente, J; Estella-Hermoso de Mendoza, A; Lana, H; Mollinedo, F; Villa-Pulgarin, JA, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alderliesten, MC | 1 |
| Klarenbeek, JB | 3 |
| van der Luit, AH | 3 |
| van Lummel, M | 1 |
| Jones, DR | 1 |
| Zerp, S | 1 |
| Divecha, N | 1 |
| Verheij, M | 3 |
| van Blitterswijk, WJ | 3 |
| Estella-Hermoso de Mendoza, A | 1 |
| Campanero, MA | 1 |
| Lana, H | 1 |
| Villa-Pulgarin, JA | 1 |
| de la Iglesia-Vicente, J | 1 |
| Mollinedo, F | 1 |
| Blanco-Prieto, MJ | 1 |
| Vink, SR | 2 |
| Perrissoud, D | 1 |
| Solary, E | 1 |
| Andreesen, R | 1 |
| Osterholz, J | 1 |
| Luckenbach, GA | 1 |
| Costabel, U | 1 |
| Schulz, A | 1 |
| Speth, V | 1 |
| Munder, PG | 1 |
| Löhr, GW | 1 |
| Berdel, WE | 3 |
| Luz, A | 1 |
| Rastetter, J | 1 |
| Fink, U | 1 |
| Gössner, W | 1 |
| Messerschmidt, O | 1 |
| Dietzfelbinger, HF | 1 |
| Lang, A | 1 |
| Oberberg, D | 1 |
| Rastetter, JW | 1 |
| Alunni-Bistocchi, G | 1 |
| Orvietani, PL | 1 |
| Ricci, A | 1 |
| Binaglia, L | 2 |
| Orlando, M | 1 |
| Orlando, P | 1 |
| Vagnetti, D | 1 |
| Mancini, A | 1 |
| Santarella, B | 1 |
| Santos, GW | 1 |
| Colvin, OM | 1 |
| Roos, G | 1 |
1 review available for edelfosine and Lymphoma
| Article | Year |
|---|---|
Pharmacological purging of bone marrow with reference to autografting.
Topics: Adolescent; Adult; Animals; Bleomycin; Bone Marrow; Bone Marrow Transplantation; Cell Separation; Ch | 1986 |
1 trial available for edelfosine and Lymphoma
| Article | Year |
|---|---|
Pharmacological purging of bone marrow with reference to autografting.
Topics: Adolescent; Adult; Animals; Bleomycin; Bone Marrow; Bone Marrow Transplantation; Cell Separation; Ch | 1986 |
10 other studies available for edelfosine and Lymphoma
| Article | Year |
|---|---|
Phosphoinositide phosphatase SHIP-1 regulates apoptosis induced by edelfosine, Fas ligation and DNA damage in mouse lymphoma cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; DNA Damage; Down-Regulation; Extracellular Signal-Regulated MA | 2011 |
Complete inhibition of extranodal dissemination of lymphoma by edelfosine-loaded lipid nanoparticles.
Topics: Animals; Diglycerides; Fatty Acids; Humans; Leukemic Infiltration; Lymph Nodes; Lymphoma; Mice; Nano | 2012 |
A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Endocytosis; HeLa Cells; Humans; Lympho | 2007 |
Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Li | 2007 |
Tumor cytotoxicity of human macrophages after incubation with synthetic analogues of 2-lysophosphatidylcholine.
Topics: Antineoplastic Agents; Cell Line; Cytotoxicity, Immunologic; Humans; In Vitro Techniques; Lymphoma; | 1984 |
Alkyl-lysophospholipids lack influence on the occurrence of radiation-induced lymphomas and AKR-leukemia.
Topics: Animals; Female; Leukemia, Radiation-Induced; Lymphoma; Lysophosphatidylcholines; Male; Mice; Mice, | 1983 |
Differential cytotoxicity of an ether lipid on lymphoma and bone marrow cells and its role in purging malignant lymphoid cells from remission bone marrow contaminated with tumor cells.
Topics: Antineoplastic Agents; Bone Marrow; Bone Marrow Transplantation; Cell Death; Cells, Cultured; Dose-R | 1992 |
Synthesis of 1-O-alkyl-2-O-methyl-glycerophospholipids with potential antitumor activity.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chemical Phenomena; Chemistry; Lymphoma; Mice; Phosph | 1990 |
Effect of alkyl-lysophospholipid analogs on the morphology of a murine lymphoma cell line.
Topics: Animals; Cell Division; Lymphoma; Mice; Microscopy, Electron; Phospholipid Ethers; Spleen; Tumor Cel | 1990 |
Sensitivity of human hematopoietic cell lines to an alkyl-lysophospholipid-derivative.
Topics: Cell Cycle; Cell Division; Cell Line; Cell Survival; DNA, Neoplasm; Hematopoietic Stem Cells; Humans | 1986 |