edelfosine has been researched along with Lymphoma, Mantle-Cell in 3 studies
edelfosine: RN given refers to parent cpd
edelfosine : A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
1-octadecyl-2-methylglycero-3-phosphocholine : A glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.
Lymphoma, Mantle-Cell: A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Edelfosine was taken up by malignant cells, whereas normal resting lymphocytes hardly incorporated the drug." | 1.36 | In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts. ( Blanco-Prieto, MJ; Campanero, MA; Colomer, D; de Frias, M; de la Iglesia-Vicente, J; Estella-Hermoso de Mendoza, A; Gajate, C; Gil, J; Mollinedo, F; Roué, G; Villa-Pulgarin, JA, 2010) |
| " Besides, no statistical differences were observed between the pharmacokinetic parameters of BALB/c and SCID mice." | 1.35 | Antitumor alkyl ether lipid edelfosine: tissue distribution and pharmacokinetic behavior in healthy and tumor-bearing immunosuppressed mice. ( Blanco-Prieto, MJ; Campanero, MA; de la Iglesia-Vicente, J; Estella-Hermoso de Mendoza, A; Gajate, C; Mollinedo, F, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mollinedo, F | 3 |
| Gajate, C | 3 |
| Estella-Hermoso de Mendoza, A | 2 |
| Campanero, MA | 2 |
| de la Iglesia-Vicente, J | 2 |
| Blanco-Prieto, MJ | 2 |
| Villa-Pulgarin, JA | 1 |
| de Frias, M | 1 |
| Roué, G | 1 |
| Gil, J | 1 |
| Colomer, D | 1 |
1 review available for edelfosine and Lymphoma, Mantle-Cell
| Article | Year |
|---|---|
Lipid rafts as major platforms for signaling regulation in cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Survival; Humans; Lymphoma, Mantle-Cell; Membrane Mi | 2015 |
2 other studies available for edelfosine and Lymphoma, Mantle-Cell
| Article | Year |
|---|---|
Antitumor alkyl ether lipid edelfosine: tissue distribution and pharmacokinetic behavior in healthy and tumor-bearing immunosuppressed mice.
Topics: Animals; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Lymphocytes; Lymphoma, Mantl | 2009 |
In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Hum | 2010 |