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edelfosine and Leucocythaemia

edelfosine has been researched along with Leucocythaemia in 29 studies

edelfosine: RN given refers to parent cpd
edelfosine : A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
1-octadecyl-2-methylglycero-3-phosphocholine : A glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.

Research Excerpts

ExcerptRelevanceReference
" A survey of the in vitro activity of racemic 1-octadecyl-2-methoxy-glycero-3 phosphorylcholine on in vitro clonogenicity in soft agar and tritiated thymidine incorporation was conducted on bone marrow specimens from a series of patients with acute myelogenous leukemia (AML) and chronic myelocytic leukemia (CML) and hematologically normal individuals."3.67The effect of alkyl-lysophospholipids on tritiated thymidine incorporation and clonogenicity in vitro of normal and leukemic human cells. ( Long, RC; Somberg, LB; Vogler, WR; Whigham, EA; Winton, EF, 1984)
"440 and the ether-linked lipoidal amine CP-46,665 on tritiated thymidine uptake and trypan blue dye exclusion were tested in vitro in various freshly explanted cell samples from human nonneoplastic bone marrow and human leukemias."3.67Cytotoxic effects of ether lipids and derivatives in human nonneoplastic bone marrow cells and leukemic cells in vitro. ( Berdel, WE; Eibl, H; Fink, U; Fromm, M; Jehn, U; Rastetter, J; Reichert, A; Schick, HD; Ulm, K; Unger, C, 1987)
" Encapsulation of edelfosine (ET) in lipid nanoparticles (LNs) improves its oral bioavailability and decreases its toxicity."1.39Edelfosine lipid nanosystems overcome drug resistance in leukemic cell lines. ( Blanco-Príeto, MJ; Estella-Hermoso de Mendoza, A; Lasa-Saracíbar, B; Mollinedo, F; Odero, MD, 2013)
"Edelfosine treatment recruited Hsp90, c-Jun N-terminal kinase (JNK) and apoptotic molecules in lipid rafts, but not the JNK regulators apoptosis signal-regulating kinase 1 (ASK1) and Daxx, or the survival signaling molecules extracellular signal-regulated kinase (ERK) and Akt."1.35Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy. ( Gajate, C; González-Camacho, F; Mollinedo, F; Nieto-Miguel, T, 2008)
" All the mice given cells not treated with ALP succumbed to leukemia, whereas there was a dose-response increase in survival in those given ALP treated cells."1.28Purging leukemia remission marrows with alkyl-lysophospholipids, preclinical and clinical results. ( Berdel, WE; Glasser, L; Okamoto, S; Olson, AC; Vogler, WR, 1990)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199010 (34.48)18.7374
1990's14 (48.28)18.2507
2000's4 (13.79)29.6817
2010's1 (3.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lasa-Saracíbar, B1
Estella-Hermoso de Mendoza, A1
Mollinedo, F5
Odero, MD1
Blanco-Príeto, MJ1
Nieto-Miguel, T2
Gajate, C4
González-Camacho, F1
Vogler, WR10
Whigham, EA1
Somberg, LB1
Long, RC1
Winton, EF3
Heesbeen, EC1
Rijksen, G1
van Heugten, HG1
Verdonck, LF1
Berdel, WE12
Berkovic, D1
Berkovic, K1
Fleer, EA2
Eibl, H5
Unger, C3
Shoji, M4
Fukuhara, T1
Olson, AC5
Hajdu, J2
Raynor, R1
Kuo, JF3
Yamazaki, T1
Sieber, F1
Geller, RB1
Brochstein, JA1
Beveridge, RA1
Dalton, WS1
Miller, KB1
Lazarus, HM1
Santos-Beneit, AM1
Macho, A1
Lazaro, Md1
Hernandez-De Rojas, A1
Modolell, M1
Muñoz, E1
Min, WS1
Park, HM1
Han, CH1
Park, JW1
Kim, CC1
Kim, DJ2
Okamoto, S4
Heffner, LT1
Gordon, DS1
Raynor, RL1
Nomura, H1
Glasser, L1
Santos, GW1
Colvin, OM1
Lai, CS1
Joseph, J1
Shih, CC1
Chabot, MC1
Wykle, RL1
Modest, EJ1
Daniel, LW1
Oishi, K1
Zheng, B1
White, JF1
Fink, U3
Rastetter, J3
Danhauser, S1
Schick, HD2
Fromm, M2
Reichert, A2
Busch, R1
Jehn, U1
Ulm, K1
Kötting, J1
Bartsch, HH1
Nagel, GA1
Pfizenmaier, K1
Roos, G1

Reviews

2 reviews available for edelfosine and Leucocythaemia

ArticleYear
Ether lipids in cancer chemotherapy.
    The Keio journal of medicine, 1990, Volume: 39, Issue:2

    Topics: Animals; Antineoplastic Agents; Bone Marrow Transplantation; Drug Evaluation; Drug Evaluation, Precl

1990
Pharmacological purging of bone marrow with reference to autografting.
    Clinics in haematology, 1986, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Animals; Bleomycin; Bone Marrow; Bone Marrow Transplantation; Cell Separation; Ch

1986

Trials

6 trials available for edelfosine and Leucocythaemia

ArticleYear
Autologous bone marrow transplantation with alkyl-lysophospholipid-purged marrow.
    Journal of hematotherapy, 1993,Spring, Volume: 2, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc

1993
A phase II trial of autologous bone marrow transplantation (ABMT) in acute leukemia with edelfosine purged bone marrow.
    Advances in experimental medicine and biology, 1996, Volume: 416

    Topics: Adolescent; Aged; Antineoplastic Agents; Bone Marrow Transplantation; Child; Child, Preschool; Combi

1996
Alkyl-lysophospholipid purging for autologous bone marrow transplantation in acute leukemia in second or subsequent remission after extramedullary relapse.
    Progress in clinical and biological research, 1992, Volume: 377

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Marrow Purging; Bone Marrow Transplantation; Humans;

1992
[Purging of leukemic cells using alkyllysophospholipid].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1992, Volume: 33, Issue:7

    Topics: Antineoplastic Agents; Bone Marrow Purging; Humans; Leukemia; Phospholipid Ethers

1992
Pharmacological purging of bone marrow with reference to autografting.
    Clinics in haematology, 1986, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Animals; Bleomycin; Bone Marrow; Bone Marrow Transplantation; Cell Separation; Ch

1986
Clinical phase I pilot study of the alkyl lysophospholipid derivative ET-18-OCH3.
    Lipids, 1987, Volume: 22, Issue:11

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma;

1987

Other Studies

22 other studies available for edelfosine and Leucocythaemia

ArticleYear
Edelfosine lipid nanosystems overcome drug resistance in leukemic cell lines.
    Cancer letters, 2013, Jul-01, Volume: 334, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Chemistry, Physical; Drug Delivery Sys

2013
Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells.
    The Journal of biological chemistry, 2006, May-26, Volume: 281, Issue:21

    Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Endoplasmic Reticulum; fas Receptor; HeLa Cel

2006
Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy.
    Oncogene, 2008, Mar-13, Volume: 27, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; HL-60 Cells; HSP90 Heat-Shock Proteins; Humans; JNK Mitogen-Activa

2008
The effect of alkyl-lysophospholipids on tritiated thymidine incorporation and clonogenicity in vitro of normal and leukemic human cells.
    Experimental hematology, 1984, Volume: 12, Issue:7

    Topics: Bone Marrow Cells; Cell Line; Circadian Rhythm; Colony-Forming Units Assay; Humans; Leukemia; Lysoph

1984
Influence of serum levels on leukemic cell destruction by the ether lipid ET-18-OCH3.
    Leukemia research, 1995, Volume: 19, Issue:6

    Topics: Antineoplastic Agents; Biological Factors; Bone Marrow Cells; Bone Marrow Purging; Cell Division; Ce

1995
Inhibition of calcium-dependent protein kinase C by hexadecylphosphocholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine do not correlate with inhibition of proliferation of HL60 and K562 cell lines.
    European journal of cancer (Oxford, England : 1990), 1994, Volume: 30A, Issue:4

    Topics: Antineoplastic Agents; Cell Division; Cell Membrane; Cytosol; Diglycerides; Dose-Response Relationsh

1994
Different mechanisms of inhibition by alkyl-lysophospholipid and phorbol ester of granulocyte-macrophage colony-stimulating factor binding to human leukemic cell lines.
    Experimental hematology, 1994, Volume: 22, Issue:1

    Topics: Antineoplastic Agents; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Iodine Radioisotope

1994
Structure-function relationships of alkyl-lysophospholipid analogs in selective antitumor activity.
    Lipids, 1993, Volume: 28, Issue:6

    Topics: Antineoplastic Agents; Cell Division; Dose-Response Relationship, Drug; Hematopoietic Stem Cells; Hu

1993
The alkyl-lysophospholipid, ET-18-OCH3 synergistically enhances the Merocyanine 540-mediated photoinactivation of leukemia cells: implications for the extracorporeal purging of autologous hematopoietic stem cells.
    Bone marrow transplantation, 1997, Volume: 19, Issue:2

    Topics: Animals; Antineoplastic Agents; Blood Component Removal; Cell Death; Combined Modality Therapy; Drug

1997
Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells.
    International journal of cancer, 2000, Apr-15, Volume: 86, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; DNA Fragmentation; Enzyme

2000
The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells.
    Blood, 2001, Dec-15, Volume: 98, Issue:13

    Topics: Apoptosis; beta-Cyclodextrins; Cell Membrane; Centrifugation, Density Gradient; Cholesterol; Cyclode

2001
Efficacy of purging clonogenic leukemia cells using ether lipid and hyperthermia for autologous bone marrow transplantation.
    Progress in clinical and biological research, 1992, Volume: 377

    Topics: Antineoplastic Agents; Bone Marrow Purging; Bone Marrow Transplantation; Colony-Forming Units Assay;

1992
Autologous bone marrow transplantation in acute leukemia with marrow purged with alkyl-lysophospholipid.
    Blood, 1992, Sep-15, Volume: 80, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Agents; Blood Platelets; Bone Marrow; Bone Marrow Cells; Bone Marr

1992
Comparison of selective cytotoxicity of alkyl lysophospholipids.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Antineoplastic Agents; Cell Survival; Hematopoietic Stem Cells; Humans; Leukemia; Phospholipid Ether

1991
Purging leukemia remission marrows with alkyl-lysophospholipids, preclinical and clinical results.
    Progress in clinical and biological research, 1990, Volume: 333

    Topics: Acute Disease; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplan

1990
Molecular dynamics of antitumor ether-linked phospholipids in model membranes: a spin-label study.
    Biochemical and biophysical research communications, 1989, May-15, Volume: 160, Issue:3

    Topics: 1,2-Dipalmitoylphosphatidylcholine; Antineoplastic Agents; DNA; Electron Spin Resonance Spectroscopy

1989
Correlation of ether lipid content of human leukemia cell lines and their susceptibility to 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine.
    Cancer research, 1989, Aug-15, Volume: 49, Issue:16

    Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Leukemia; Membrane Lipids; Phosphol

1989
Inhibition of Na,K-ATPase and sodium pump by anticancer ether lipids and protein kinase C inhibitors ET-18-OCH3 and BM 41.440.
    Biochemical and biophysical research communications, 1988, Dec-30, Volume: 157, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Membrane; Cerebral Cortex; Erythrocytes; Humans; Leukemia; Lyso

1988
Structure-cytotoxicity studies on alkyl lysophospholipids and some analogs in leukemic blasts of human origin in vitro.
    Lipids, 1987, Volume: 22, Issue:11

    Topics: Antineoplastic Agents; Cell Survival; Cytotoxins; Glyceryl Ethers; Humans; Leukemia; Lysophospholipi

1987
Cytotoxic effects of ether lipids and derivatives in human nonneoplastic bone marrow cells and leukemic cells in vitro.
    Lipids, 1987, Volume: 22, Issue:11

    Topics: Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Survival; Cytotoxins; Humans; Leukemia;

1987
Sensitivity of leukemia cell lines to cytotoxic alkyl-lysophospholipids in relation to O-alkyl cleavage enzyme activities.
    Journal of the National Cancer Institute, 1987, Volume: 78, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship,

1987
Sensitivity of human hematopoietic cell lines to an alkyl-lysophospholipid-derivative.
    Leukemia research, 1986, Volume: 10, Issue:2

    Topics: Cell Cycle; Cell Division; Cell Line; Cell Survival; DNA, Neoplasm; Hematopoietic Stem Cells; Humans

1986