edelfosine has been researched along with Leishmania Infection in 3 studies
edelfosine: RN given refers to parent cpd
edelfosine : A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
1-octadecyl-2-methylglycero-3-phosphocholine : A glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study shows that the antileishmanial and anticancer actions of edelfosine share some common signaling processes, with mitochondria and raft-located FOF1-ATP synthase being critical in the killing process, thus identifying novel druggable targets for the treatment of leishmaniasis." | 3.85 | Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine. ( Botet, J; Cuesta-Marbán, Á; Gajate, C; Jimenez, A; Justies, N; Modolell, M; Mollinedo, F; Müller, I; Revuelta, JL; Varela-M, RE; Villa-Pulgarín, JA, 2017) |
| "The alkylphosphocholine class of drugs, including edelfosine and miltefosine, has recently shown promise in the treatment of protozoal and fungal diseases, most notably, leishmaniasis." | 3.72 | Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine. ( Birchmore, JL; Hanson, PK; Malone, L; Nichols, JW, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Villa-Pulgarín, JA | 2 |
| Gajate, C | 1 |
| Botet, J | 1 |
| Jimenez, A | 1 |
| Justies, N | 1 |
| Varela-M, RE | 2 |
| Cuesta-Marbán, Á | 1 |
| Müller, I | 2 |
| Modolell, M | 2 |
| Revuelta, JL | 1 |
| Mollinedo, F | 2 |
| Yepes, E | 1 |
| Muñoz, DL | 1 |
| Robledo, SM | 1 |
| Muskus, CE | 1 |
| López-Abán, J | 1 |
| Muro, A | 1 |
| Vélez, ID | 1 |
| Hanson, PK | 1 |
| Malone, L | 1 |
| Birchmore, JL | 1 |
| Nichols, JW | 1 |
3 other studies available for edelfosine and Leishmania Infection
| Article | Year |
|---|---|
Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.
Topics: Animals; Antineoplastic Agents; Antiprotozoal Agents; Cell Survival; Cells, Cultured; Disease Models | 2017 |
In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites.
Topics: Animals; Antiprotozoal Agents; Apoptosis; Cell Survival; Cricetinae; Disease Models, Animal; Ether; | 2012 |
Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine.
Topics: Alleles; Antiprotozoal Agents; Biological Transport; Cell Division; Cell Membrane; Cycloheximide; Do | 2003 |