Page last updated: 2024-10-21

edelfosine and Kahler Disease

edelfosine has been researched along with Kahler Disease in 3 studies

edelfosine: RN given refers to parent cpd
edelfosine : A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
1-octadecyl-2-methylglycero-3-phosphocholine : A glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.

Research Excerpts

ExcerptRelevanceReference
"Despite recent advances in treatment, multiple myeloma (MM) remains an incurable malignancy."1.36Lipid raft-targeted therapy in multiple myeloma. ( Blanco-Prieto, MJ; Campanero, MA; de la Iglesia-Vicente, J; Estella-Hermoso de Mendoza, A; Gajate, C; Mollinedo, F; Villa-Pulgarin, JA, 2010)
" Dose-response curves after drug exposure for 4 and 24 hours reached plateaus at 75 and 25 microg/mL, respectively."1.29Response of human multiple myeloma-derived cell lines to alkyl-lysophospholipid. ( Cook, P; Dalton, WS; Fiederlein, RL; Glasser, L; Powis, G; Vogler, WR, 1996)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mollinedo, F2
de la Iglesia-Vicente, J1
Gajate, C2
Estella-Hermoso de Mendoza, A1
Villa-Pulgarin, JA1
Campanero, MA1
Blanco-Prieto, MJ1
Glasser, L1
Dalton, WS1
Fiederlein, RL1
Cook, P1
Powis, G1
Vogler, WR1

Other Studies

3 other studies available for edelfosine and Kahler Disease

ArticleYear
Lipid raft-targeted therapy in multiple myeloma.
    Oncogene, 2010, Jul-01, Volume: 29, Issue:26

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Humans; Membran

2010
Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.
    Blood, 2007, Jan-15, Volume: 109, Issue:2

    Topics: Apoptosis; Caspase 8; Cell Line, Tumor; Cell Proliferation; fas Receptor; Fas-Associated Death Domai

2007
Response of human multiple myeloma-derived cell lines to alkyl-lysophospholipid.
    Experimental hematology, 1996, Volume: 24, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Calcium; Dose-Response Relationship, Drug; Drug Resistance, Neopl

1996