edelfosine has been researched along with Disease Models, Animal in 8 studies
edelfosine: RN given refers to parent cpd
edelfosine : A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
1-octadecyl-2-methylglycero-3-phosphocholine : A glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study shows that the antileishmanial and anticancer actions of edelfosine share some common signaling processes, with mitochondria and raft-located FOF1-ATP synthase being critical in the killing process, thus identifying novel druggable targets for the treatment of leishmaniasis." | 3.85 | Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine. ( Botet, J; Cuesta-Marbán, Á; Gajate, C; Jimenez, A; Justies, N; Modolell, M; Mollinedo, F; Müller, I; Revuelta, JL; Varela-M, RE; Villa-Pulgarín, JA, 2017) |
| "Patients with liver cirrhosis of different aetiologies are at a risk to develop HCC." | 2.66 | Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma. ( Aslanidis, C; Buechler, C, 2020) |
| "Despite recent advances in treatment, multiple myeloma (MM) remains an incurable malignancy." | 1.36 | Lipid raft-targeted therapy in multiple myeloma. ( Blanco-Prieto, MJ; Campanero, MA; de la Iglesia-Vicente, J; Estella-Hermoso de Mendoza, A; Gajate, C; Mollinedo, F; Villa-Pulgarin, JA, 2010) |
| "High corticosterone levels were detected during stages of acute paralysis, whereas a decrease to normal levels was noted during each recovery phase." | 1.29 | Immunoregulation and drug treatment in chronic relapsing experimental allergic encephalomyelitis in the Lewis rat. ( Borel, JF; Chabannes, D; Kovarik, J, 1995) |
| "Experimental autoimmune encephalomyelitis is a model disease for multiple sclerosis which can be induced by injecting rats with myelin basic protein, MBP." | 1.28 | Alkyllysophospholipid prevents induction of experimental allergic encephalomyelitis. ( Klein-Franke, A; Munder, PG, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Buechler, C | 1 |
| Aslanidis, C | 1 |
| Villa-Pulgarín, JA | 3 |
| Gajate, C | 2 |
| Botet, J | 1 |
| Jimenez, A | 1 |
| Justies, N | 1 |
| Varela-M, RE | 2 |
| Cuesta-Marbán, Á | 1 |
| Müller, I | 2 |
| Modolell, M | 2 |
| Revuelta, JL | 1 |
| Mollinedo, F | 3 |
| Abramowski, P | 1 |
| Steinbach, K | 1 |
| Zander, AR | 1 |
| Martin, R | 1 |
| de la Iglesia-Vicente, J | 1 |
| Estella-Hermoso de Mendoza, A | 1 |
| Campanero, MA | 1 |
| Blanco-Prieto, MJ | 1 |
| Yepes, E | 1 |
| Muñoz, DL | 1 |
| Robledo, SM | 1 |
| Muskus, CE | 1 |
| López-Abán, J | 1 |
| Muro, A | 1 |
| Vélez, ID | 1 |
| Garic-Stankovic, A | 1 |
| Hernandez, MR | 1 |
| Chiang, PJ | 1 |
| Debelak-Kragtorp, KA | 1 |
| Flentke, GR | 1 |
| Armant, DR | 1 |
| Smith, SM | 1 |
| Kovarik, J | 1 |
| Chabannes, D | 1 |
| Borel, JF | 1 |
| Klein-Franke, A | 1 |
| Munder, PG | 1 |
1 review available for edelfosine and Disease Models, Animal
| Article | Year |
|---|---|
Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Prolif | 2020 |
7 other studies available for edelfosine and Disease Models, Animal
| Article | Year |
|---|---|
Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.
Topics: Animals; Antineoplastic Agents; Antiprotozoal Agents; Cell Survival; Cells, Cultured; Disease Models | 2017 |
Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Encephalomyelitis, | 2014 |
Lipid raft-targeted therapy in multiple myeloma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Humans; Membran | 2010 |
In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites.
Topics: Animals; Antiprotozoal Agents; Apoptosis; Cell Survival; Cricetinae; Disease Models, Animal; Ether; | 2012 |
Ethanol triggers neural crest apoptosis through the selective activation of a pertussis toxin-sensitive G protein and a phospholipase Cbeta-dependent Ca2+ transient.
Topics: Animals; Apoptosis; Calcium; Chick Embryo; Disease Models, Animal; Enzyme Activation; Estrenes; Etha | 2005 |
Immunoregulation and drug treatment in chronic relapsing experimental allergic encephalomyelitis in the Lewis rat.
Topics: Animals; Autoimmune Diseases; Concanavalin A; Corticosterone; Cyclosporine; Dexamethasone; Disease M | 1995 |
Alkyllysophospholipid prevents induction of experimental allergic encephalomyelitis.
Topics: Adjuvants, Immunologic; Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental | 1992 |