edelfosine has been researched along with Cancer of Ovary in 5 studies
edelfosine: RN given refers to parent cpd
edelfosine : A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
1-octadecyl-2-methylglycero-3-phosphocholine : A glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ether lipid analogue 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) has been shown to be a direct inhibitor of Swiss 3T3 fibroblast and BG1 ovarian adenocarcinoma cell cytosolic phosphoinositide selective phospholipase C (PIPLC) using [3H]-phosphatidylinositol-(4, 5)-bisphosphate ([3H]PIP2) as the substrate." | 3.68 | Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. ( Gratas, C; Melder, D; Modest, EJ; Powis, G; Riebow, J; Seewald, MJ, 1992) |
| " The dose-response curve for BG-1 cells after continuous exposure to ET-18-OMe alone was exponential with a small shoulder (Dq = 0." | 1.28 | Cytotoxic interactions of heat and an ether lipid analogue in human ovarian carcinoma cells. ( Fujiwara, K; Modest, EJ; Wallen, CA; Welander, CE, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujiwara, K | 2 |
| Daniel, LW | 1 |
| Modest, EJ | 5 |
| Wallen, CA | 2 |
| Diomede, L | 1 |
| Damia, G | 1 |
| D'Incalci, M | 1 |
| Imperatori, L | 1 |
| Algeri, M | 1 |
| Salmona, M | 1 |
| Powis, G | 1 |
| Seewald, MJ | 1 |
| Gratas, C | 1 |
| Melder, D | 1 |
| Riebow, J | 1 |
| Welander, CE | 1 |
| Noseda, A | 1 |
| Berens, ME | 1 |
| White, JG | 1 |
5 other studies available for edelfosine and Cancer of Ovary
| Article | Year |
|---|---|
Relationship of cell survival, drug dose, and drug uptake after 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine treatment.
Topics: Antineoplastic Agents; Cell Cycle; Cell Survival; Female; Humans; Ovarian Neoplasms; Phospholipid Et | 1994 |
In vivo anti-tumor activity of synthetic ether lipids is not enhanced by pharmacological modulation of tumor lipid composition.
Topics: Animals; Antineoplastic Agents; Cell Membrane; Cholesterol; Drug Combinations; Female; Glycerides; L | 1994 |
Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.
Topics: 3T3 Cells; Adenocarcinoma; Animals; Cell Division; Choline; Female; Mice; Ovarian Neoplasms; Phospha | 1992 |
Cytotoxic interactions of heat and an ether lipid analogue in human ovarian carcinoma cells.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Female; Hot Tempe | 1989 |
In vitro antiproliferative activity of combinations of ether lipid analogues and DNA-interactive agents against human tumor cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division | 1988 |