edelfosine has been researched along with Benign Neoplasms in 23 studies
edelfosine: RN given refers to parent cpd
edelfosine : A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
1-octadecyl-2-methylglycero-3-phosphocholine : A glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Edelfosine is mainly known for its anticancer properties, although it is also applied in the treatment of other diseases, like autoimmune, anti-HIV and antiparasitic." | 2.50 | Edelfosine in membrane environment - the Langmuir monolayer studies. ( Dynarowicz-Latka, P; Hac-Wydro, K, 2014) |
| "Edelfosine treatment also induced a redistribution of lipid rafts from the plasma membrane to mitochondria, suggesting a raft-mediated link between plasma membrane and mitochondria." | 2.50 | Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine. ( Gajate, C; Mollinedo, F, 2014) |
| "SK2-3 channels are expressed in tumors and have been assigned a biological function in cancer cells: the enhancement of cell proliferation and cell migration by hijacking the functions of SK2 and SK3 channels, respectively." | 2.48 | Targeting SKCa channels in cancer: potential new therapeutic approaches. ( Bougnoux, P; Chantôme, A; Girault, A; Haelters, JP; Jaffrés, PA; Joulin, V; Potier-Cartereau, M; Vandier, C, 2012) |
| "Akt is activated in most human cancers and contributes to cell growth, proliferation and cellular survival pathway." | 1.39 | Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines. ( Alam, MM; Joh, EH; Kim, B; Kim, DH; Lee, YS; Park, H, 2013) |
| "Edelfosine treatment led to the generation of the p20 caspase-8 cleavage fragment of BAP31, directing proapoptotic signals between the ER and the mitochondria." | 1.34 | Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells. ( Fonteriz, RI; Gajate, C; López-Hernández, S; Mollinedo, F; Nieto-Miguel, T; Vay, L, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 13 (56.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Plano, D | 1 |
| Baquedano, Y | 1 |
| Moreno-Mateos, D | 1 |
| Font, M | 1 |
| Jiménez-Ruiz, A | 1 |
| Palop, JA | 1 |
| Sanmartín, C | 1 |
| Alam, MM | 1 |
| Joh, EH | 1 |
| Park, H | 1 |
| Kim, B | 1 |
| Kim, DH | 1 |
| Lee, YS | 1 |
| Van Slambrouck, S | 1 |
| Steelant, WF | 1 |
| Dynarowicz-Latka, P | 1 |
| Hac-Wydro, K | 2 |
| Gajate, C | 6 |
| Mollinedo, F | 6 |
| Flasiński, M | 1 |
| Wydro, P | 1 |
| Dynarowicz-Łątka, P | 1 |
| Melo-Lima, S | 1 |
| Jaffrès, PA | 2 |
| Bouchet, AM | 1 |
| Couthon-Gourvès, H | 1 |
| Chantôme, A | 2 |
| Potier-Cartereau, M | 2 |
| Besson, P | 1 |
| Bougnoux, P | 2 |
| Vandier, C | 2 |
| Fernández, M | 1 |
| Hornillos, V | 1 |
| Delgado, J | 1 |
| Amat-Guerri, F | 1 |
| Acuña, AU | 1 |
| Nieto-Miguel, T | 3 |
| Villa-Pulgarín, JA | 1 |
| González-García, C | 1 |
| Ceña, V | 1 |
| Semini, G | 1 |
| Klein, A | 1 |
| Danker, K | 1 |
| Girault, A | 1 |
| Haelters, JP | 1 |
| Joulin, V | 1 |
| Lee, S | 1 |
| Kim, J | 1 |
| Shim, G | 1 |
| Kim, S | 1 |
| Han, SE | 1 |
| Kim, K | 1 |
| Kwon, IC | 1 |
| Choi, Y | 1 |
| Kim, YB | 1 |
| Kim, CW | 1 |
| Oh, YK | 1 |
| van Blitterswijk, WJ | 1 |
| Verheij, M | 1 |
| Fonteriz, RI | 1 |
| Vay, L | 1 |
| López-Hernández, S | 1 |
| Dymond, M | 1 |
| Attard, G | 1 |
| Postle, AD | 1 |
| Candal, FJ | 1 |
| Bosse, DC | 1 |
| Vogler, WR | 1 |
| Ades, EW | 1 |
| Peters, AC | 1 |
| Ahmad, I | 1 |
| Janoff, AS | 1 |
| Pushkareva, MY | 1 |
| Mayhew, E | 1 |
| Mareel, M | 1 |
| Bracke, M | 1 |
| Bruyneel, E | 1 |
| Van Larebeke, N | 1 |
| De Mets, M | 1 |
| Berdel, WE | 3 |
| Okamoto, S | 1 |
| Fink, U | 2 |
| Rastetter, J | 2 |
| Von Hoff, DD | 1 |
| Unger, C | 1 |
| Schick, HD | 1 |
| Reichert, A | 1 |
| Eibl, H | 1 |
8 reviews available for edelfosine and Benign Neoplasms
| Article | Year |
|---|---|
1-O-octadecyl-2-O-methylglycero-3-phosphocholine (Edelfosine) and cancer cell invasion: a short review.
Topics: Animals; Antineoplastic Agents; Humans; Neoplasm Invasiveness; Neoplasms; Phospholipid Ethers; Signa | 2014 |
Edelfosine in membrane environment - the Langmuir monolayer studies.
Topics: Antineoplastic Agents; Cholesterol; Gangliosides; Humans; Membrane Fluidity; Membrane Microdomains; | 2014 |
Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine.
Topics: Animals; Antineoplastic Agents; Apoptosis; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Huma | 2014 |
Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Movement; Drug Design; Glycolipids; Humans; Ion Chan | 2016 |
Targeting SKCa channels in cancer: potential new therapeutic approaches.
Topics: Antineoplastic Agents; Apamin; Humans; Molecular Targeted Therapy; Neoplasms; Phosphodiesterase Inhi | 2012 |
Anticancer mechanisms and clinical application of alkylphospholipids.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Membrane; Endocytosis; Humans; Neoplasms; O | 2013 |
Invasion and metastasis control: implications for increased therapeutic index of antitumor drugs.
Topics: Antineoplastic Agents; Catechin; Dipyridamole; Glycoproteins; Humans; Microtubules; Neoplasm Invasiv | 1990 |
Ether lipids in cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Bone Marrow Transplantation; Drug Evaluation; Drug Evaluation, Precl | 1990 |
1 trial available for edelfosine and Benign Neoplasms
| Article | Year |
|---|---|
Clinical phase I pilot study of the alkyl lysophospholipid derivative ET-18-OCH3.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma; | 1987 |
14 other studies available for edelfosine and Benign Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Selenocyanates and diselenides: a new class of potent antileishmanial agents.
Topics: Aminophenols; Animals; Antiprotozoal Agents; Cell Line, Tumor; Cyanates; Humans; Inhibitory Concentr | 2011 |
Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines.
Topics: Antineoplastic Agents; Carboxylic Acids; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Humans | 2013 |
Influence of platelet-activating factor, lyso-platelet-activating factor and edelfosine on Langmuir monolayers imitating plasma membranes of cell lines differing in susceptibility to anti-cancer treatment: the effect of plasmalogen level.
Topics: Antineoplastic Agents; Cell Membrane; HL-60 Cells; Humans; K562 Cells; Membranes, Artificial; Neopla | 2014 |
Triggers and signaling cross-talk controlling cell death commitment.
Topics: Antineoplastic Agents; Cell Death; Humans; Models, Biological; Neoplasms; Phospholipid Ethers; Signa | 2015 |
Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria.
Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; Biological Transport; Female; Fluorescence; Gene Ex | 2011 |
Impact of alkylphospholipids on the gene expression profile of HaCaT cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line; Cell Membrane; Cell Movement; Cel | 2011 |
Tetraiodothyroacetic acid-tagged liposomes for enhanced delivery of anticancer drug to tumor tissue via integrin receptor.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Delivery Systems; Humans; Integrin alphaVbeta | 2012 |
Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Endoplasmic Reticulum; fas Receptor; HeLa Cel | 2006 |
Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Pro | 2007 |
Testing the hypothesis that amphiphilic antineoplastic lipid analogues act through reduction of membrane curvature elastic stress.
Topics: Antineoplastic Agents; Cell Membrane; Choline-Phosphate Cytidylyltransferase; Elasticity; HL-60 Cell | 2008 |
Inhibition of induced angiogenesis in a human microvascular endothelial cell line by ET-18-OCH3.
Topics: Antineoplastic Agents; Cell Adhesion Molecules; Depression, Chemical; Dose-Response Relationship, Dr | 1994 |
Growth inhibitory effects of liposome-associated 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine.
Topics: Animals; Calcium; Cell Division; DNA Fragmentation; Drug Resistance, Neoplasm; Hemolysis; Humans; Li | 1997 |
Ether lipid derivatives: antineoplastic activity in vitro and the structure-activity relationship.
Topics: Antineoplastic Agents; Cell Survival; Female; Humans; Lysophosphatidylcholines; Neoplasms; Phospholi | 1986 |