Page last updated: 2024-08-23

edatrexate and Lung Neoplasms

edatrexate has been researched along with Lung Neoplasms in 24 studies

Research

Studies (24)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (4.17)	18.7374
1990's	19 (79.17)	18.2507
2000's	4 (16.67)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Gralla, RJ	1
Cheson, B; Christian, M; Feigal, EG; Friedman, MA; Grever, M	1
Grant, SC; Kris, MG	1
Klastersky, J	1
Grant, SC; Kris, MG; Miller, VA; Pisters, KM; Rigas, JR	1
Chou, TC; Fletcher, TS; Hack, FM; Perez, EA	1
Chou, TC; Hack, FM; Perez, EA; Webber, LM	1
Braich, TA; Jett, JR; Kardinal, CG; Mailliard, JA; Michalak, JC; Morton, RF; Su, JQ; Veeder, MH; Wiesenfeld, M	1
Allen, R; Harland, SJ; Hartley, JM; Lamond, P; Nicholson, PW; Souhami, RL	1
Otter, GM; Schmid, FA; Sirotnak, FM	1
Edelman, MJ; Gandara, DR	1
Anderson, M; Chu, E; Dearing, MP; Englee-Miller, MJ; Gazdar, AF; Kramer, BS; Kratzke, RA; Mulshine, JL; Venzon, D; Weinstein, J	1
Crowley, JJ; Edelman, MJ; Gandara, DR; Lau, DH; Livingston, RB	1
Colwell, WT; DeGraw, JI; Piper, JR; Sirotnak, FM	1
Kris, MG; Miller, VA; Scher, HI; Sirotnak, FM; Zakowski, MF	1
Chronowski, G; Heelan, RT; Kris, MG; Laurie, SA; Pfister, DG; Pisters, KM; Sirotnak, FM; Tong, WP	1
Colon-Otero, G; Geyer, S; Hillman, SH; Jett, JJ; Krook, JE; Marks, RS; Niedringhaus, RD; Sloan, J; Tschetter, LK; Wiesenfeld, M; Windschitl, HE	1
Gandara, DR; Kuriakose, P; Perez, EA	1
Allen, R; Harper, PG; Lamond, P; Rudd, RM; Souhami, RL; Spiro, SG	1
Yoshimura, A	1
Hong, WK; Lee, JS; Murphy, WK; Pang, A; Shirinian, MH	1
Dimery, IW; Fossella, FV; Glisson, BS; Hong, WK; Lee, JS; Libshitz, HI; Lippman, SM; Murphy, WK; Pang, AC; Shin, DM	1
Hong, WK; Jeffries, D; Lee, JS; Libshitz, HI; Murphy, WK	1
Burke, MT; Gralla, RJ; Heelan, RT; Kris, MG; Marks, LD; Shum, KY	1

Reviews

7 review(s) available for edatrexate and Lung Neoplasms

Article	Year
Edatrexate studies in non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 1995, Volume: 12 Suppl 1 Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Folic Acid Antagonists; Humans; Lung Neoplasms	1995
New chemotherapeutic agents in non-small-cell lung cancer. Seminars in oncology, 1993, Volume: 20, Issue:2 Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Drug Design; Humans; Interferons; Irinotecan; Lung Neoplasms; Paclitaxel; Topotecan; Vinblastine; Vinorelbine	1993
New antineoplastic agents in lung cancer 1988-1993. Cancer treatment and research, 1995, Volume: 72 Topics: Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Clinical Trials as Topic; Humans; Irinotecan; Lung Neoplasms; Nitrosourea Compounds; Organophosphorus Compounds; Paclitaxel; Teniposide; Vinblastine; Vinorelbine	1995
New drug for therapy of non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 1994, Volume: 11 Suppl 3 Topics: Aminopterin; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Irinotecan; Lung Neoplasms; Paclitaxel; Taxoids; Vinblastine; Vinorelbine	1994
New chemotherapeutic agents for non-small cell lung cancer. Chest, 1995, Volume: 107, Issue:6 Suppl Topics: Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Irinotecan; Lung Neoplasms; Paclitaxel; Quinoxalines; Sulfanilamides; Taxoids; Topotecan; Vinblastine; Vinorelbine	1995
Promising new agents in the treatment of non-small cell lung cancer. Cancer chemotherapy and pharmacology, 1996, Volume: 37, Issue:5 Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Lung Neoplasms; Paclitaxel; Taxoids; Vinblastine; Vinorelbine	1996
[New analogues of methotrexate]. Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:13 Topics: Aminopterin; Animals; Antineoplastic Agents; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Methotrexate; Trimetrexate	1992

Trials

7 trial(s) available for edatrexate and Lung Neoplasms

Article	Year
Phase II trial of edatrexate in small cell lung cancer. Cancer, 1994, Feb-15, Volume: 73, Issue:4 Topics: Aged; Aminopterin; Carcinoma, Small Cell; Female; Humans; Lung Neoplasms; Male; Middle Aged; Survival Analysis	1994
Phase II trial of edatrexate plus carboplatin in metastatic non-small-cell lung cancer: a Southwest Oncology Group study. Cancer chemotherapy and pharmacology, 1997, Volume: 41, Issue:1 Topics: Adult; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mouth Mucosa; Neutropenia; Survival Analysis; Treatment Outcome	1997
Phase I and pharmacological study of two schedules of the antifolate edatrexate in combination with cisplatin. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:3 Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Cisplatin; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Time Factors; Treatment Outcome	2001
A phase II trial of edatrexate, vinblastine, adriamycin, cisplastin, and filgrastim (EVAC/G-CSF) in patients with non-small-cell carcinoma of the lungs: a North Central Cancer Treatment Group Trial. American journal of clinical oncology, 2001, Volume: 24, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Doxorubicin; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Lung Neoplasms; Male; Middle Aged; Recombinant Proteins; Remission Induction; Sickness Impact Profile; Survival Analysis; Vinblastine	2001
Phase I trial of edatrexate in advanced breast and other cancers. Cancer investigation, 2002, Volume: 20, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Infusions, Intravenous; Karnofsky Performance Status; Lung Neoplasms; Maximum Tolerated Dose; Melanoma; Menopause; Middle Aged; Receptors, Estrogen; Receptors, Progesterone; Treatment Outcome	2002
Phase II study of Edatrexate in stage III and IV non-small-cell lung cancer. Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:6 Topics: Aged; Aminopterin; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Neoplasm Staging	1992
Edatrexate improves the antitumor effects of cyclophosphamide and cisplatin against non-small cell lung cancer. Cancer, 1991, Sep-01, Volume: 68, Issue:5 Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation; Drug Synergism; Female; Humans; Lung Neoplasms; Male; Middle Aged	1991

Other Studies

10 other study(ies) available for edatrexate and Lung Neoplasms

Article	Year
Modulation of intrinsic in vitro resistance to carboplatin by edatrexate in the A549 human nonsmall cell lung cancer cell line. Oncology research, 1994, Volume: 6, Issue:3 Topics: Aminopterin; Antineoplastic Agents; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Humans; Kinetics; Lung Neoplasms; Time Factors; Tumor Cells, Cultured	1994
Schedule-dependent synergism of edatrexate and cisplatin in combination in the A549 lung-cancer cell line as assessed by median-effect analysis. Cancer chemotherapy and pharmacology, 1993, Volume: 33, Issue:3 Topics: Adenocarcinoma; Aminopterin; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Humans; Lung Neoplasms; Tumor Cells, Cultured	1993
Pharmacokinetics of 10-ethyl-10-deaza-aminopterin, edatrexate, given weekly for non-small-cell lung cancer. Cancer chemotherapy and pharmacology, 1993, Volume: 31, Issue:4 Topics: Aminopterin; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chromatography, High Pressure Liquid; Creatinine; Half-Life; Humans; Lung Neoplasms; Metabolic Clearance Rate	1993
Markedly improved efficacy of edatrexate compared to methotrexate in a high-dose regimen with leucovorin rescue against metastatic murine solid tumors. Cancer research, 1993, Feb-01, Volume: 53, Issue:3 Topics: Adenocarcinoma; Aminopterin; Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fibrosarcoma; Leucovorin; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma, Experimental; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Salvage Therapy	1993
Dipyridamole mediated enhanced antiproliferative activity of 10-ethyl-10-deazaaminopterin (10-EDAM) against human lung cancer cell lines. Journal of cellular biochemistry. Supplement, 1996, Volume: 24 Topics: Aminopterin; Biological Transport; Cell Division; Depression, Chemical; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Folic Acid Antagonists; Growth Inhibitors; Humans; Lung Neoplasms; Methotrexate; Nucleosides; Thymidine; Tumor Cells, Cultured	1996
A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice. Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:4 Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Lung Neoplasms; Methotrexate; Mice; Mice, Nude; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured	1998
Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:12 Topics: Aminopterin; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carboplatin; Cell Division; Cisplatin; Docetaxel; Dose-Response Relationship, Drug; ErbB Receptors; Female; Gefitinib; Humans; Immunohistochemistry; Lung Neoplasms; Male; Maximum Tolerated Dose; Mice; Mice, Nude; Neoplasm Transplantation; Paclitaxel; Prostatic Neoplasms; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Taxoids; Time Factors; Tumor Cells, Cultured; Vinblastine; Vinorelbine; Vulvar Neoplasms	2000
Alleviation by leucovorin of the dose-limiting toxicity of edatrexate: potential for improved therapeutic efficacy. Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:3 Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation; Drug Tolerance; Female; Folic Acid Antagonists; Humans; Leucovorin; Lung Neoplasms; Male; Middle Aged; Stomatitis	1991
Phase II study of 10-ethyl-10-deaza-aminopterin (10-EdAM; CGP 30 694) for stage IIIB or IV non-small cell lung cancer. Investigational new drugs, 1990, Volume: 8, Issue:3 Topics: Adult; Aged; Aminopterin; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid Antagonists; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pleural Effusion	1990
Phase II study of 10-ethyl-10-deaza-aminopterin in patients with stage III and IV non-small-cell lung cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1988, Volume: 6, Issue:3 Topics: Aged; Aminopterin; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Female; Folic Acid Antagonists; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging	1988