edaravone has been researched along with Reperfusion Injury in 93 studies
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This research aimed to evaluate the therapeutic effect of edaravone on lower limb ischemia-reperfusion injury by MRI images of graph patch-based directional curvelet transform (GPBDCT), compression reconstruction algorithm." | 9.51 | Deep Learning Reconstruction Algorithm-Based MRI Image Evaluation of Edaravone in the Treatment of Lower Limb Ischemia-Reperfusion Injury. ( Duan, X; Fang, C; Liu, F; Liu, J; Xiao, J; Ye, R, 2022) |
| " Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a clinically approved cerebroprotective agent against ischemic stroke and amyotrophic lateral sclerosis, while new formulations that enable improvement of its physicochemical properties and biodistribution are desired." | 8.31 | Development of Edaravone Ionic Liquids and Their Application for the Treatment of Cerebral Ischemia/Reperfusion Injury. ( Fukuta, T; Ikeda-Imafuku, M; Iwao, Y, 2023) |
| "Our previous studies confirm that exogenous reduced nicotinamide adenine dinucleotide phosphate (NADPH) exerts a neuroprotective effect in animal models of ischemic stroke, and its primary mechanism is related to anti-oxidative stress and improved energy metabolism." | 8.12 | NADPH is superior to NADH or edaravone in ameliorating metabolic disturbance and brain injury in ischemic stroke. ( Chen, Z; Han, R; Li, M; Mao, GH; Qin, ZH; She, J; Sheng, R; Wang, F; Wang, XX; Wu, JC; Zhang, R, 2022) |
| "The study aimed to investigate the influences of edaravone on necroptosis-related proteins and oxidative stress in rats with lower extremity ischemia/reperfusion (I/R) injury." | 8.12 | Influences of Edaravone on Necroptosis-Related Proteins and Oxidative Stress in Rats with Lower Extremity Ischemia/Reperfusion Injury. ( Hu, Z; Li, Y; Wang, L; Zhao, G; Zhao, L, 2022) |
| "Mild hypothermia (MH) and edaravone (EDA) exert neuroprotective effects against cerebral ischemia/reperfusion (I/R) injury through activation of the nuclear factor erythroid 2‑related factor 2 (Nrf2) pathway." | 7.96 | Protective effects of combined treatment with mild hypothermia and edaravone against cerebral ischemia/reperfusion injury via oxidative stress and Nrf2 pathway regulation. ( Dai, M; Gao, C; Kang, F; Liu, R; Wang, X; Wu, Z; Yu, H, 2020) |
| "This study was conducted to explore whether the effect of edaravone (5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol3-one, EDR) can ameliorate renal warm ischemia-reperfusion injury (IRI) by modulating endoplasmic reticulum stress (ERS) and its downstream effector after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) in a rat model." | 7.96 | Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model. ( Chen, MH; Fu, ZY; Li, N; Lu, JY; Wu, ZJ; Zheng, JH, 2020) |
| "To investigate the protective effect of edaravone and danshensu conjugate (IM-009) on focal cerebral ischemia-reperfusion injury in rats and its underlying mechanisms." | 7.81 | [Protective effect of novel edaravone and danshensu conjugate on focal cerebral ischemia-reperfusion injury in rats and its underlying mechanism]. ( Chen, H; Hou, S; Zhang, S, 2015) |
| " The free-radical scavenger edaravone is used in combination with the recombinant tissue plasminogen activator alteplase to treat acute ischemic stroke." | 7.81 | The free-radical scavenger edaravone accelerates thrombolysis with alteplase in an experimental thrombosis model. ( Ishii, H; Sakamoto, K; Sato, T; Yamamoto, J; Yamashita, T, 2015) |
| "Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction." | 7.78 | Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury. ( Chen, X; Gao, M; Lei, S; Li, L; Li, W; Li, X; Liu, Y; Lu, H; Wang, N; Zhang, P; Zheng, J, 2012) |
| "To increase the survival rate of patients with acute superior mesenteric artery thromboembolism (ASMAT) treated by catheter thrombolysis, we examined the effects of delivering edaravone and asialoerythropoietin, agents with tissue-protective activities, using a rabbit autologous fibrin clot ASMAT model." | 7.76 | Does the concomitant intra-arterial injection of asialoerythropoietin and edaravone mitigate ischaemic mucosal damage after acute superior mesenteric artery thromboembolism in a rabbit autologous fibrin clot model? ( Kashiwagi, A; Murata, K; Nitta, N; Ohta, S; Seko, A; Sonoda, A; Sugimoto, T; Takahashi, M; Takemura, S; Uzu, T; Yokomaku, Y, 2010) |
| "To compare the protective effect of nerve growth factor (NGF) and edaravone (a free radical scavenger) pretreatment against cerebral ischemia/reperfusion (I/R) injury to nerve cells." | 7.76 | [A comparative study on the protection effect of nerve growth factor and edaravone pretreatment against cerebral ischemia/reperfusion injury]. ( Fu, JQ; Liu, H; Wang, DF, 2010) |
| "The aim of this study is to clarify whether edaravone postconditioning had protective effect against renal ischemia/reperfusion injury and to compare the protective effect between ischemic postconditioning and edaravone postconditioning." | 7.76 | Protective effect of edaravone against renal ischemia/reperfusion injury and compared with ischemic postconditioning in rats. ( Li, Y; Xia, AZ; Xing, SH, 2010) |
| "We investigated the effects of edaravone, a free radical scavenger, on peripheral nerve ischemia-reperfusion injury caused by ligation of vessels supplying the sciatic and tibial nerves in rats." | 7.75 | Effect of the free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury. ( Iida, H; Nagasaka, T; Shindo, K; Shiozawa, Z, 2009) |
| "The aim of this study was to evaluate the effects of intra-arterial administration of edaravone after superior mesenteric artery (SMA) thromboembolism in a rabbit model." | 7.75 | Edaravone prevents bowel infarction after acute superior mesenteric artery thromboembolism using autologous fibrin clots in a rabbit model. ( Miyagawa, Y; Murata, K; Nitta, N; Ohta, S; Seko, A; Sonoda, A; Takahashi, M; Takemura, S, 2009) |
| "Prophylactic administration of edaravone exerted a significant protective effect against postoperative neurologic dysfunction after antegrade selective cerebral perfusion in a canine model with old cerebral infarction." | 7.74 | Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction. ( Akuzawa, S; Bashar, AH; Fujie, M; Kazui, T; Ohishi, K; Ohkura, K; Suzuki, K; Suzuki, T; Terada, H; Washiyama, N; Yamamoto, S; Yamashita, K, 2007) |
| "To investigate the effect of edaravone on renal ischemia-reperfusion injury in rats." | 7.74 | [Protective effects of edaravone on renal ischemia-reperfusion injury in rats]. ( Huang, HY; Xu, QP; Zhang, G, 2008) |
| "Edaravone attenuates lung IR injury by suppressing oxidative damage and PLA(2) activation, which otherwise partially mediates edema formation and neutrophil extravasation through PAF-R activation." | 7.73 | MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation. ( Akamatsu, H; Reyes, YA; Shimoyama, T; Sunamori, M, 2006) |
| "Edaravone ameliorates renal ischemia/reperfusion injury by scavenging free radicals produced in renal tubular cells and inhibiting lipid peroxidation." | 7.72 | Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney. ( Doi, K; Fujita, T; Nakao, A; Noiri, E; Suzuki, Y, 2004) |
| "We investigated whether or not a combination of the selective thrombin inhibitor, argatroban, and the free radical scavenger, edaravone (MCI-186), ameliorates postischemic hypoperfusion and decreases mortality after 15 min of forebrain ischemia in the gerbil." | 7.71 | Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. ( Jin, YJ; Mima, T; Park, KC; Raicu, V; Shimizu, K, 2002) |
| "Edaravone (ED) has a protective effect on IRI." | 5.72 | Effect of Edaravone on MicroRNA Expression in Exosomes after Hepatic Ischemia-reperfusion Injury. ( Fei, Y; Huang, G; Shao, J; Sun, H; Wang, L; Yang, J; Zheng, C; Zou, S, 2022) |
| "Edaravone dexborneol is a novel neuroprotective agent consisting of edaravone and borneol." | 5.72 | Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO-1 signaling pathway in mice. ( Dong, Y; Gao, Y; Hu, M; Lv, P; Xu, J; Xu, L; Zhang, J, 2022) |
| "Edaravone (3 mg/kg) was administered intravenously to 14 C57BL/6 mice just before reperfusion." | 5.56 | Effects of Edaravone on Nitric Oxide, Hydroxyl Radicals and Neuronal Nitric Oxide Synthase During Cerebral Ischemia and Reperfusion in Mice. ( Araki, N; Hirayama, M; Ishizawa, K; Ito, Y; Kawasaki, H; Kitabayashi, C; Nagai, T; Nishioka, R; Takahashi, K; Tanaka, A; Yamamoto, T; Yamazato, M, 2020) |
| "This research aimed to evaluate the therapeutic effect of edaravone on lower limb ischemia-reperfusion injury by MRI images of graph patch-based directional curvelet transform (GPBDCT), compression reconstruction algorithm." | 5.51 | Deep Learning Reconstruction Algorithm-Based MRI Image Evaluation of Edaravone in the Treatment of Lower Limb Ischemia-Reperfusion Injury. ( Duan, X; Fang, C; Liu, F; Liu, J; Xiao, J; Ye, R, 2022) |
| "Edaravone was found to have a protective effect against I/R injury by directly inhibiting lipid peroxidation of the myocyte by free radicals in skeletal muscles and may also reduce the secondary edema and inflammatory infiltration incidence of oxidative stress on tissue." | 5.39 | Protective effect of edaravone for tourniquet-induced ischemia-reperfusion injury on skeletal muscle in murine hindlimb. ( Akeda, K; Hasegawa, M; Hori, K; Iino, T; Satonaka, H; Sudo, A; Tsujii, M; Uchida, A; Uemura, T, 2013) |
| "Edaravone or saline were administered after reperfusion for 30 min." | 5.36 | Effect of edaravone on ischemia/reperfusion injury in rat urinary bladder--changes in smooth muscle cell phenotype and contractile function. ( Hanai, T; Matsumoto, S; Shimizu, N; Sugimoto, K; Uemura, H, 2010) |
| "When edaravone was administered prior to ischemia and at the time of initiation of the reperfusion, liver injury was markedly reduced." | 5.33 | Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage. ( Connor, HD; Fujii, H; Kono, H; Maki, A; Mason, RP; Rusyn, I; Woods, CG, 2006) |
| "Edaravone (10 mg/kg) was delivered intravenously before ischemia and after reperfusion to prevent the neutrophil activation." | 5.33 | Treatment with edaravone improves the survival rate in renal warm ischemia-reperfusion injury using rat model. ( Funao, K; Hayama, T; Kawahito, Y; Matsuyama, M; Nakatani, T; Sano, H; Sugimura, K; Takemoto, Y; Tsuchida, K; Yoshimura, R, 2006) |
| "Edaravone is a synthetic radical scavenger that has been used in acute stroke." | 5.33 | A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation. ( Fujita, M; Furukawa, H; Jin, MB; Nakayama, M; Shimamura, T; Suzuki, T; Tahara, M; Taniguchi, M; Todo, S, 2005) |
| "Edaravone has been used for protection against I/R injury in patients with cerebral infarction." | 5.33 | Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. ( Horikawa, S; Ito, K; Ozasa, H, 2005) |
| "Edaravone was administered via intravenous infusion at 5 min before reperfusion was achieved by removal of the clamp." | 5.32 | Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats. ( Ichikawa, H; Imamoto, E; Isozaki, Y; Katada, K; Kokura, S; Naito, Y; Okanoue, T; Takagi, T; Tomatsuri, N; Uchiyama, K; Yoshida, N; Yoshikawa, T, 2004) |
| " Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a clinically approved cerebroprotective agent against ischemic stroke and amyotrophic lateral sclerosis, while new formulations that enable improvement of its physicochemical properties and biodistribution are desired." | 4.31 | Development of Edaravone Ionic Liquids and Their Application for the Treatment of Cerebral Ischemia/Reperfusion Injury. ( Fukuta, T; Ikeda-Imafuku, M; Iwao, Y, 2023) |
| "Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)." | 4.21 | ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; Monte, A; Monteiro, L; Montomoli, J; Moore, EE; Moore, HB; Moore, PK; Mor, MK; Moratalla-López, N; Moratilla Lapeña, L; Moreira, R; Moreno, MA; Mörk, AC; Morton, M; Mosier, JM; Mou, LH; Mougharbel, AS; Muccillo-Baisch, AL; Muñoz-Serrano, AJ; Mustafa, B; Nair, GM; Nakanishi, I; Nakanjako, D; Naraparaju, K; Nawani, N; Neffati, R; Neil, EC; Neilipovitz, D; Neira-Borrajo, I; Nelson, MT; Nery, PB; Nese, M; Nguyen, F; Nguyen, MH; Niazy, AA; Nicolaï, J; Nogueira, F; Norbäck, D; Novaretti, JV; O'Donnell, T; O'Dowd, A; O'Malley, DM; Oaknin, A; Ogata, K; Ohkubo, K; Ojha, M; Olaleye, MT; Olawande, B; Olomo, EJ; Ong, EWY; Ono, A; Onwumere, J; Ortiz Bibriesca, DM; Ou, X; Oza, AM; Ozturk, K; Özütemiz, C; Palacio-Pastrana, C; Palaparthi, A; Palevsky, PM; Pan, K; Pantanetti, S; Papachristou, DJ; Pariani, A; Parikh, CR; Parissis, J; Paroul, N; Parry, S; Patel, N; Patel, SM; Patel, VC; Pawar, S; Pefura-Yone, EW; Peixoto Andrade, BCO; Pelepenko, LE; Peña-Lora, D; Peng, S; Pérez-Moro, OS; Perez-Ortiz, AC; 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Winkler, C; Wirman, AP; Wong, S; Woods, CM; Wu, B; Wu, C; Wu, F; Wu, P; Wu, S; Wu, Y; Wu, YN; Wu, ZH; Wurtzel, JGT; Xia, L; Xia, Z; Xia, ZZ; Xiao, H; Xie, C; Xin, ZM; Xing, Y; Xing, Z; Xu, S; Xu, SB; Xu, T; Xu, X; Xu, Y; Xue, L; Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022) |
| "Our previous studies confirm that exogenous reduced nicotinamide adenine dinucleotide phosphate (NADPH) exerts a neuroprotective effect in animal models of ischemic stroke, and its primary mechanism is related to anti-oxidative stress and improved energy metabolism." | 4.12 | NADPH is superior to NADH or edaravone in ameliorating metabolic disturbance and brain injury in ischemic stroke. ( Chen, Z; Han, R; Li, M; Mao, GH; Qin, ZH; She, J; Sheng, R; Wang, F; Wang, XX; Wu, JC; Zhang, R, 2022) |
| "The study aimed to investigate the influences of edaravone on necroptosis-related proteins and oxidative stress in rats with lower extremity ischemia/reperfusion (I/R) injury." | 4.12 | Influences of Edaravone on Necroptosis-Related Proteins and Oxidative Stress in Rats with Lower Extremity Ischemia/Reperfusion Injury. ( Hu, Z; Li, Y; Wang, L; Zhao, G; Zhao, L, 2022) |
| "Mild hypothermia (MH) and edaravone (EDA) exert neuroprotective effects against cerebral ischemia/reperfusion (I/R) injury through activation of the nuclear factor erythroid 2‑related factor 2 (Nrf2) pathway." | 3.96 | Protective effects of combined treatment with mild hypothermia and edaravone against cerebral ischemia/reperfusion injury via oxidative stress and Nrf2 pathway regulation. ( Dai, M; Gao, C; Kang, F; Liu, R; Wang, X; Wu, Z; Yu, H, 2020) |
| "This study was conducted to explore whether the effect of edaravone (5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol3-one, EDR) can ameliorate renal warm ischemia-reperfusion injury (IRI) by modulating endoplasmic reticulum stress (ERS) and its downstream effector after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) in a rat model." | 3.96 | Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model. ( Chen, MH; Fu, ZY; Li, N; Lu, JY; Wu, ZJ; Zheng, JH, 2020) |
| " The free-radical scavenger edaravone is used in combination with the recombinant tissue plasminogen activator alteplase to treat acute ischemic stroke." | 3.81 | The free-radical scavenger edaravone accelerates thrombolysis with alteplase in an experimental thrombosis model. ( Ishii, H; Sakamoto, K; Sato, T; Yamamoto, J; Yamashita, T, 2015) |
| "To investigate the protective effect of edaravone and danshensu conjugate (IM-009) on focal cerebral ischemia-reperfusion injury in rats and its underlying mechanisms." | 3.81 | [Protective effect of novel edaravone and danshensu conjugate on focal cerebral ischemia-reperfusion injury in rats and its underlying mechanism]. ( Chen, H; Hou, S; Zhang, S, 2015) |
| " We have previously reported that edaravone, a free radical scavenger, has a cytoprotective effect on warm ischemia-reperfusion injury and improves the function of liver grafts from NHBDs in a rat model of ischemia-reperfusion." | 3.80 | Edaravone, a free radical scavenger, improves the graft viability on liver transplantation from non-heart-beating donors in pigs. ( Fujio, A; Goto, M; Hara, Y; Kashiwadate, T; Kawagishi, N; Maida, K; Miyagi, S; Miyazawa, K; Murakami, K; Nakanishi, C; Nakanishi, W; Ohuchi, N; Yamaya, H, 2014) |
| "Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction." | 3.78 | Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury. ( Chen, X; Gao, M; Lei, S; Li, L; Li, W; Li, X; Liu, Y; Lu, H; Wang, N; Zhang, P; Zheng, J, 2012) |
| "In a rabbit model with aortic clamping up to 30 minutes, which consistently produces complete paraplegia in rabbits, spinal cord damage was partially reduced by topical cooling with transvertebral cooling pads or the injection of edaravone into the clamped segment of aorta, but was more effectively protected by a combined use of these two strategies." | 3.77 | New method for absolute spinal cord ischemia protection in rabbits. ( Herlambang, B; Hiyama, E; Mizukami, T; Orihashi, K; Sueda, T; Takahashi, S; Uchida, N, 2011) |
| "The aim of this study is to clarify whether edaravone postconditioning had protective effect against renal ischemia/reperfusion injury and to compare the protective effect between ischemic postconditioning and edaravone postconditioning." | 3.76 | Protective effect of edaravone against renal ischemia/reperfusion injury and compared with ischemic postconditioning in rats. ( Li, Y; Xia, AZ; Xing, SH, 2010) |
| "To compare the protective effect of nerve growth factor (NGF) and edaravone (a free radical scavenger) pretreatment against cerebral ischemia/reperfusion (I/R) injury to nerve cells." | 3.76 | [A comparative study on the protection effect of nerve growth factor and edaravone pretreatment against cerebral ischemia/reperfusion injury]. ( Fu, JQ; Liu, H; Wang, DF, 2010) |
| "To increase the survival rate of patients with acute superior mesenteric artery thromboembolism (ASMAT) treated by catheter thrombolysis, we examined the effects of delivering edaravone and asialoerythropoietin, agents with tissue-protective activities, using a rabbit autologous fibrin clot ASMAT model." | 3.76 | Does the concomitant intra-arterial injection of asialoerythropoietin and edaravone mitigate ischaemic mucosal damage after acute superior mesenteric artery thromboembolism in a rabbit autologous fibrin clot model? ( Kashiwagi, A; Murata, K; Nitta, N; Ohta, S; Seko, A; Sonoda, A; Sugimoto, T; Takahashi, M; Takemura, S; Uzu, T; Yokomaku, Y, 2010) |
| "We demonstrate that edaravone inhibits rtPA-induced cerebral hemorrhage in the ischemic brain of rats via the inhibition of MMP-9 expression in vivo, which is substantiated by inhibition of MMP-9 expression and NF-kappaB activation in HBECs." | 3.75 | Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. ( Kinouchi, T; Kitazato, KT; Nagahiro, S; Shimada, K; Tada, Y; Uno, M; Yagi, K, 2009) |
| "The aim of this study was to evaluate the effects of intra-arterial administration of edaravone after superior mesenteric artery (SMA) thromboembolism in a rabbit model." | 3.75 | Edaravone prevents bowel infarction after acute superior mesenteric artery thromboembolism using autologous fibrin clots in a rabbit model. ( Miyagawa, Y; Murata, K; Nitta, N; Ohta, S; Seko, A; Sonoda, A; Takahashi, M; Takemura, S, 2009) |
| "We investigated the effects of edaravone, a free radical scavenger, on peripheral nerve ischemia-reperfusion injury caused by ligation of vessels supplying the sciatic and tibial nerves in rats." | 3.75 | Effect of the free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury. ( Iida, H; Nagasaka, T; Shindo, K; Shiozawa, Z, 2009) |
| "Prophylactic administration of edaravone exerted a significant protective effect against postoperative neurologic dysfunction after antegrade selective cerebral perfusion in a canine model with old cerebral infarction." | 3.74 | Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction. ( Akuzawa, S; Bashar, AH; Fujie, M; Kazui, T; Ohishi, K; Ohkura, K; Suzuki, K; Suzuki, T; Terada, H; Washiyama, N; Yamamoto, S; Yamashita, K, 2007) |
| "To investigate the effect of edaravone on renal ischemia-reperfusion injury in rats." | 3.74 | [Protective effects of edaravone on renal ischemia-reperfusion injury in rats]. ( Huang, HY; Xu, QP; Zhang, G, 2008) |
| "Edaravone attenuates lung IR injury by suppressing oxidative damage and PLA(2) activation, which otherwise partially mediates edema formation and neutrophil extravasation through PAF-R activation." | 3.73 | MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation. ( Akamatsu, H; Reyes, YA; Shimoyama, T; Sunamori, M, 2006) |
| "Edaravone exerted a significant protective effect on the spinal cord against ischemia-reperfusion injury by suppressing the level of free radical species, which was demonstrated with the microdialysis method." | 3.73 | Experimental study on the protective effects of edaravone against ischemic spinal cord injury. ( Bashar, AH; Ikeda, Y; Kazui, T; Ohkura, K; Suzuki, K; Suzuki, T; Terada, H; Umemura, K; Washiyama, N; Yamashita, K; Yasuike, J, 2005) |
| "Edaravone ameliorates renal ischemia/reperfusion injury by scavenging free radicals produced in renal tubular cells and inhibiting lipid peroxidation." | 3.72 | Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney. ( Doi, K; Fujita, T; Nakao, A; Noiri, E; Suzuki, Y, 2004) |
| "The effects of ozagrel (CAS 82571-53-7), a thromboxane A2-synthetase inhibitor, and norphenazone (CAS 89-25-8), a free-radical scavenger, on cerebral infarction were assessed using the suture-induced middle cerebral artery occlusion (MCAO) model and a microthrombosis model." | 3.72 | Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger. ( Ichikawa, K; Imamura, T; Kiguchi, S; Kobayashi, K; Kojima, M; Yamazaki, Y, 2003) |
| "We investigated whether or not a combination of the selective thrombin inhibitor, argatroban, and the free radical scavenger, edaravone (MCI-186), ameliorates postischemic hypoperfusion and decreases mortality after 15 min of forebrain ischemia in the gerbil." | 3.71 | Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. ( Jin, YJ; Mima, T; Park, KC; Raicu, V; Shimizu, K, 2002) |
| "Edaravone dexborneol is a novel neuroprotective agent consisting of edaravone and borneol." | 1.72 | Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO-1 signaling pathway in mice. ( Dong, Y; Gao, Y; Hu, M; Lv, P; Xu, J; Xu, L; Zhang, J, 2022) |
| "Edaravone (ED) has a protective effect on IRI." | 1.72 | Effect of Edaravone on MicroRNA Expression in Exosomes after Hepatic Ischemia-reperfusion Injury. ( Fei, Y; Huang, G; Shao, J; Sun, H; Wang, L; Yang, J; Zheng, C; Zou, S, 2022) |
| "Edaravone was administered intraperitoneally 30 min before radiotherapy (5 Gy)." | 1.62 | Protective effect of edaravone against radiation-induced ovarian injury: a histopathological and immunohistochemical evaluation in an experimental rat model. ( Alver, A; Gürlek, B; Mete Ural, Ü, 2021) |
| "Edaravone is a potent free radical scavenger that has a promising role in combating many acute lung injuries." | 1.56 | Edaravone attenuates lung injury in a hind limb ischemia-reperfusion rat model: A histological, immunohistochemical and biochemical study. ( Aboregela, AM; Kassab, AA; Shalaby, AM, 2020) |
| "Edaravone (3 mg/kg) was administered intravenously to 14 C57BL/6 mice just before reperfusion." | 1.56 | Effects of Edaravone on Nitric Oxide, Hydroxyl Radicals and Neuronal Nitric Oxide Synthase During Cerebral Ischemia and Reperfusion in Mice. ( Araki, N; Hirayama, M; Ishizawa, K; Ito, Y; Kawasaki, H; Kitabayashi, C; Nagai, T; Nishioka, R; Takahashi, K; Tanaka, A; Yamamoto, T; Yamazato, M, 2020) |
| "Kidney ischemia-reperfusion injury is a common pathophysiological phenomenon in the clinic." | 1.56 | Edaravone alleviates cell apoptosis and mitochondrial injury in ischemia-reperfusion-induced kidney injury via the JAK/STAT pathway. ( Bai, L; Bai, X; Guo, Z; Luo, D; Ren, X; Wang, D; Wang, Q; Yang, J; Zhang, E; Zhao, X, 2020) |
| "Ischemia-reperfusion injury was induced through clamping the right femoral artery in rats, with a 4-h ischemia time in all experiments." | 1.56 | Oxidative stress evaluation of skeletal muscle in ischemia-reperfusion injury using enhanced magnetic resonance imaging. ( Haga, K; Kuroda, Y; Sadahiro, M; Togashi, H; Uchida, T; Yamashita, A, 2020) |
| "Pretreatment with edaravone may reduce the level of autophagy in neurons subjected to OGD/R injury." | 1.51 | Edaravone inhibits autophagy after neuronal oxygen-glucose deprivation/recovery injury. ( Chen, J; Ding, Q; Fan, J; Gu, J; Tang, P; Wang, Q; Yin, G; Yin, J; Zhou, Z, 2019) |
| "Results from transient middle cerebral artery occlusion and permanent middle cerebral artery occlusion model, indicated that 3d could significantly reduce infarct size, improve neurobehavioral deficits, and prominently decrease attenuation of cerebral damage." | 1.42 | Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent. ( Lan, Z; Lei, M; Li, J; Liang, Z; Xu, W; Xu, X; Zhang, X; Zhao, C, 2015) |
| "Edaravone was found to have a protective effect against I/R injury by directly inhibiting lipid peroxidation of the myocyte by free radicals in skeletal muscles and may also reduce the secondary edema and inflammatory infiltration incidence of oxidative stress on tissue." | 1.39 | Protective effect of edaravone for tourniquet-induced ischemia-reperfusion injury on skeletal muscle in murine hindlimb. ( Akeda, K; Hasegawa, M; Hori, K; Iino, T; Satonaka, H; Sudo, A; Tsujii, M; Uchida, A; Uemura, T, 2013) |
| "Edaravone is a brain-penetrant free radical scavenger that is known to ameliorate postischemic neuronal dysfunction." | 1.37 | Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation. ( Hayakari, R; Imaizumi, T; Ishikawa, A; Itoh, K; Kosaka, K; Matsumiya, T; Metoki, N; Mimura, J; Ota, K; Satoh, K; Tanji, K; Yoshida, H, 2011) |
| "Edaravone or saline were administered after reperfusion for 30 min." | 1.36 | Effect of edaravone on ischemia/reperfusion injury in rat urinary bladder--changes in smooth muscle cell phenotype and contractile function. ( Hanai, T; Matsumoto, S; Shimizu, N; Sugimoto, K; Uemura, H, 2010) |
| "To validate this new model of reperfusion injury, we used two well characterized neuroprotectants, estrogen and edaravone." | 1.36 | A novel rodent model of reperfusion injury following occlusion of the middle cerebral artery. ( Connell, BJ; Saleh, TM, 2010) |
| "Edaravone pretreatment reduces the IR-induced lung mitochondrial damage in infant rabbits." | 1.35 | Pretreatment with edaravone reduces lung mitochondrial damage in an infant rabbit ischemia-reperfusion model. ( Chen, D; Chen, Y; Gu, H; Qiu, W; Zheng, L; Zhou, J, 2008) |
| "Treatment with serofendic acid (1-30 nmol) reduced the infarct volume in a dose-dependent manner." | 1.35 | Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats. ( Akaike, A; Katsuki, H; Kume, T; Nakamura, T; Niidome, T; Sugimoto, H, 2008) |
| "Edaravone was intravenously administered to rats just before reperfusion and partial (70%) hepatectomy was performed just after reperfusion." | 1.34 | Amelioration of hepatic ischemia/reperfusion injury in the remnant liver after partial hepatectomy in rats. ( Hiranuma, S; Horikawa, S; Ito, K; Koike, Y; Noda, Y; Ozasa, H, 2007) |
| "Edaravone has been used for protection against I/R injury in patients with cerebral infarction." | 1.33 | Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. ( Horikawa, S; Ito, K; Ozasa, H, 2005) |
| "Edaravone is a synthetic radical scavenger that has been used in acute stroke." | 1.33 | A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation. ( Fujita, M; Furukawa, H; Jin, MB; Nakayama, M; Shimamura, T; Suzuki, T; Tahara, M; Taniguchi, M; Todo, S, 2005) |
| "Edaravone or saline was administered into the femoral artery after reperfusion for 30 minutes." | 1.33 | Edaravone protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder. ( Hanai, T; Levin, RM; Matsumoto, S; Shimizu, N; Sugiyama, T; Uemura, H; Yoshioka, N, 2005) |
| "When edaravone was administered prior to ischemia and at the time of initiation of the reperfusion, liver injury was markedly reduced." | 1.33 | Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage. ( Connor, HD; Fujii, H; Kono, H; Maki, A; Mason, RP; Rusyn, I; Woods, CG, 2006) |
| "Edaravone-treated animals showed significantly improved neurological outcome." | 1.33 | Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. ( Amemiya, S; Inaba, T; Kamiya, T; Katayama, Y; Kato, K; Nito, C; Shimazaki, K; Ueda, M, 2005) |
| "Edaravone (10 mg/kg) was delivered intravenously before ischemia and after reperfusion to prevent the neutrophil activation." | 1.33 | Treatment with edaravone improves the survival rate in renal warm ischemia-reperfusion injury using rat model. ( Funao, K; Hayama, T; Kawahito, Y; Matsuyama, M; Nakatani, T; Sano, H; Sugimura, K; Takemoto, Y; Tsuchida, K; Yoshimura, R, 2006) |
| "Edaravone was administered via intravenous infusion at 5 min before reperfusion was achieved by removal of the clamp." | 1.32 | Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats. ( Ichikawa, H; Imamoto, E; Isozaki, Y; Katada, K; Kokura, S; Naito, Y; Okanoue, T; Takagi, T; Tomatsuri, N; Uchiyama, K; Yoshida, N; Yoshikawa, T, 2004) |
| "Metabolic disruption resulted from cerebral ischemia and post-ischemia reperfusion injury was studied using proton magnetic resonance spectroscopy (1H MRS)." | 1.30 | [In vitro evaluation of metabolic change in forebrain ischemia model of rat using proton magnetic resonance spectroscopy]. ( Tanaka, N, 1997) |
| "The volume of cerebral infarction, induced by 2-h occlusion and subsequent 2-h reperfusion of MCA in Fisher-344 rats, was evaluated." | 1.30 | Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat. ( Iwai, T; Nakashima, M; Niwa, M; Uematsu, T, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (4.30) | 18.2507 |
| 2000's | 44 (47.31) | 29.6817 |
| 2010's | 27 (29.03) | 24.3611 |
| 2020's | 18 (19.35) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, J | 3 |
| Ling, J | 1 |
| Wang, X | 5 |
| Li, T | 3 |
| Liu, J | 4 |
| Lai, Y | 1 |
| Ji, H | 1 |
| Peng, S | 2 |
| Tian, J | 1 |
| Zhang, Y | 6 |
| Zhang, H | 1 |
| Yu, P | 1 |
| Lin, H | 1 |
| Jin, Z | 1 |
| Zhao, S | 2 |
| Xu, Q | 1 |
| Jin, H | 1 |
| Liu, Z | 1 |
| Yang, W | 2 |
| Zhang, L | 2 |
| Fei, Y | 1 |
| Shao, J | 1 |
| Huang, G | 1 |
| Wang, L | 7 |
| Zou, S | 1 |
| Sun, H | 1 |
| Zheng, C | 1 |
| Yang, J | 3 |
| Xu, L | 1 |
| Gao, Y | 2 |
| Hu, M | 1 |
| Dong, Y | 2 |
| Xu, J | 1 |
| Zhang, J | 2 |
| Lv, P | 1 |
| Liu, W | 3 |
| Liu, C | 4 |
| Dai, Z | 1 |
| Tang, B | 1 |
| Duan, X | 1 |
| Ye, R | 1 |
| Xiao, J | 1 |
| Fang, C | 1 |
| Liu, F | 1 |
| Zhao, G | 3 |
| Zhao, L | 2 |
| Li, Y | 10 |
| Hu, Z | 3 |
| Fukuta, T | 1 |
| Ikeda-Imafuku, M | 1 |
| Iwao, Y | 1 |
| Kassab, AA | 1 |
| Aboregela, AM | 1 |
| Shalaby, AM | 1 |
| Kawasaki, H | 1 |
| Ito, Y | 1 |
| Kitabayashi, C | 1 |
| Tanaka, A | 1 |
| Nishioka, R | 1 |
| Yamazato, M | 1 |
| Ishizawa, K | 1 |
| Nagai, T | 1 |
| Hirayama, M | 1 |
| Takahashi, K | 1 |
| Yamamoto, T | 3 |
| Araki, N | 1 |
| Fu, ZY | 1 |
| Wu, ZJ | 1 |
| Zheng, JH | 1 |
| Li, N | 2 |
| Lu, JY | 1 |
| Chen, MH | 1 |
| Kuroda, Y | 1 |
| Togashi, H | 1 |
| Uchida, T | 1 |
| Haga, K | 1 |
| Yamashita, A | 1 |
| Sadahiro, M | 1 |
| Zhao, X | 4 |
| Zhang, E | 1 |
| Ren, X | 1 |
| Bai, X | 1 |
| Wang, D | 1 |
| Bai, L | 1 |
| Luo, D | 1 |
| Guo, Z | 1 |
| Wang, Q | 2 |
| Yu, H | 1 |
| Wu, Z | 1 |
| Gao, C | 1 |
| Liu, R | 1 |
| Kang, F | 1 |
| Dai, M | 1 |
| Nese, M | 1 |
| Riboli, G | 1 |
| Brighetti, G | 1 |
| Sassi, V | 1 |
| Camela, E | 1 |
| Caselli, G | 1 |
| Sassaroli, S | 1 |
| Borlimi, R | 1 |
| Aucoin, M | 1 |
| Cooley, K | 1 |
| Saunders, PR | 1 |
| Carè, J | 1 |
| Anheyer, D | 1 |
| Medina, DN | 1 |
| Cardozo, V | 1 |
| Remy, D | 1 |
| Hannan, N | 1 |
| Garber, A | 1 |
| Velayos, M | 1 |
| Muñoz-Serrano, AJ | 1 |
| Estefanía-Fernández, K | 1 |
| Sarmiento Caldas, MC | 1 |
| Moratilla Lapeña, L | 1 |
| López-Santamaría, M | 1 |
| López-Gutiérrez, JC | 1 |
| Li, J | 2 |
| Shen, S | 1 |
| Zhang, B | 2 |
| Yu, WW | 1 |
| Toyoda, H | 1 |
| Huang, DQ | 1 |
| Le, MH | 1 |
| Nguyen, MH | 1 |
| Huang, R | 1 |
| Zhu, L | 1 |
| Wang, J | 6 |
| Xue, L | 1 |
| Liu, L | 2 |
| Yan, X | 2 |
| Huang, S | 1 |
| Xu, T | 1 |
| Li, C | 2 |
| Ji, F | 1 |
| Ming, F | 1 |
| Zhao, Y | 2 |
| Cheng, J | 1 |
| Wang, Y | 3 |
| Zhao, H | 1 |
| Hong, S | 1 |
| Chen, K | 2 |
| Zhao, XA | 1 |
| Zou, L | 1 |
| Sang, D | 1 |
| Shao, H | 1 |
| Guan, X | 1 |
| Chen, X | 3 |
| Chen, Y | 5 |
| Wei, J | 1 |
| Zhu, C | 1 |
| Wu, C | 1 |
| Moore, HB | 1 |
| Barrett, CD | 1 |
| Moore, EE | 1 |
| Jhunjhunwala, R | 1 |
| McIntyre, RC | 1 |
| Moore, PK | 1 |
| Hajizadeh, N | 1 |
| Talmor, DS | 1 |
| Sauaia, A | 1 |
| Yaffe, MB | 1 |
| Lin, Y | 1 |
| Wu, Y | 1 |
| Bao, Y | 1 |
| Yan, H | 2 |
| Ma, J | 1 |
| Fernández-Cuadros, ME | 1 |
| Albaladejo-Florín, MJ | 1 |
| Álava-Rabasa, S | 1 |
| Usandizaga-Elio, I | 1 |
| Martinez-Quintanilla Jimenez, D | 1 |
| Peña-Lora, D | 1 |
| Neira-Borrajo, I | 1 |
| López-Muñoz, MJ | 1 |
| Rodríguez-de-Cía, J | 1 |
| Pérez-Moro, OS | 1 |
| Abdallah, M | 1 |
| Alsaleh, H | 1 |
| Baradwan, A | 1 |
| Alfawares, R | 1 |
| Alobaid, A | 1 |
| Rasheed, A | 1 |
| Soliman, I | 1 |
| Wendel Garcia, PD | 1 |
| Fumeaux, T | 1 |
| Guerci, P | 1 |
| Heuberger, DM | 1 |
| Montomoli, J | 2 |
| Roche-Campo, F | 1 |
| Schuepbach, RA | 1 |
| Hilty, MP | 1 |
| Poloni, TE | 1 |
| Carlos, AF | 1 |
| Cairati, M | 1 |
| Cutaia, C | 1 |
| Medici, V | 1 |
| Marelli, E | 1 |
| Ferrari, D | 1 |
| Galli, A | 1 |
| Bognetti, P | 1 |
| Davin, A | 1 |
| Cirrincione, A | 1 |
| Ceretti, A | 1 |
| Cereda, C | 1 |
| Ceroni, M | 1 |
| Tronconi, L | 1 |
| Vitali, S | 1 |
| Guaita, A | 1 |
| Leeds, JS | 1 |
| Raviprakash, V | 1 |
| Jacques, T | 1 |
| Scanlon, N | 1 |
| Cundall, J | 1 |
| Leeds, CM | 1 |
| Riva, A | 1 |
| Gray, EH | 1 |
| Azarian, S | 1 |
| Zamalloa, A | 1 |
| McPhail, MJW | 1 |
| Vincent, RP | 1 |
| Williams, R | 1 |
| Chokshi, S | 1 |
| Patel, VC | 1 |
| Edwards, LA | 1 |
| Alqarawi, W | 1 |
| Birnie, DH | 1 |
| Golian, M | 1 |
| Nair, GM | 1 |
| Nery, PB | 1 |
| Klein, A | 1 |
| Davis, DR | 1 |
| Sadek, MM | 1 |
| Neilipovitz, D | 1 |
| Johnson, CB | 1 |
| Green, MS | 1 |
| Redpath, C | 1 |
| Miller, DC | 1 |
| Beamer, P | 1 |
| Billheimer, D | 1 |
| Subbian, V | 1 |
| Sorooshian, A | 1 |
| Campbell, BS | 1 |
| Mosier, JM | 1 |
| Novaretti, JV | 1 |
| Astur, DC | 1 |
| Cavalcante, ELB | 1 |
| Kaleka, CC | 1 |
| Amaro, JT | 1 |
| Cohen, M | 1 |
| Huang, W | 1 |
| Ling, Y | 1 |
| Qian, ZP | 1 |
| Zhang, YY | 1 |
| Huang, D | 1 |
| Xu, SB | 1 |
| Liu, XH | 1 |
| Xia, L | 1 |
| Yang, Y | 3 |
| Lu, SH | 1 |
| Lu, HZ | 1 |
| Zhang, R | 3 |
| Ma, JX | 1 |
| Tang, S | 1 |
| Li, CM | 1 |
| Wan, J | 1 |
| Wang, JF | 1 |
| Ma, JQ | 1 |
| Luo, JJ | 1 |
| Chen, HY | 2 |
| Mi, SL | 1 |
| Chen, SY | 1 |
| Su, YG | 1 |
| Ge, JB | 1 |
| Milheiro, SA | 1 |
| Gonçalves, J | 1 |
| Lopes, RMRM | 1 |
| Madureira, M | 1 |
| Lobo, L | 1 |
| Lopes, A | 1 |
| Nogueira, F | 1 |
| Fontinha, D | 1 |
| Prudêncio, M | 1 |
| M Piedade, MF | 1 |
| Pinto, SN | 1 |
| Florindo, PR | 1 |
| Moreira, R | 1 |
| Castillo-Lora, J | 1 |
| Delley, MF | 1 |
| Laga, SM | 1 |
| Mayer, JM | 1 |
| Sutjarit, N | 1 |
| Thongon, N | 1 |
| Weerachayaphorn, J | 1 |
| Piyachaturawat, P | 1 |
| Suksamrarn, A | 1 |
| Suksen, K | 1 |
| Papachristou, DJ | 1 |
| Blair, HC | 1 |
| Hu, Y | 1 |
| Shen, P | 1 |
| Zeng, N | 1 |
| Yan, D | 1 |
| Cui, L | 1 |
| Yang, K | 2 |
| Zhai, C | 1 |
| Yang, M | 1 |
| Lao, X | 1 |
| Sun, J | 1 |
| Ma, N | 1 |
| Wang, S | 1 |
| Ye, W | 1 |
| Guo, P | 1 |
| Rahimi, S | 1 |
| Singh, MP | 1 |
| Gupta, J | 1 |
| Nakanishi, I | 1 |
| Ohkubo, K | 1 |
| Shoji, Y | 1 |
| Fujitaka, Y | 1 |
| Shimoda, K | 1 |
| Matsumoto, KI | 1 |
| Fukuhara, K | 1 |
| Hamada, H | 1 |
| van der Boom, T | 1 |
| Gruppen, EG | 1 |
| Lefrandt, JD | 1 |
| Connelly, MA | 1 |
| Links, TP | 1 |
| Dullaart, RPF | 1 |
| Berry, JD | 1 |
| Bedlack, R | 1 |
| Mathews, D | 1 |
| Agnese, W | 1 |
| Apple, S | 1 |
| Meloncelli, S | 1 |
| Divizia, M | 1 |
| Germani, G | 1 |
| Adefegha, SA | 1 |
| Bottari, NB | 1 |
| Leal, DB | 1 |
| de Andrade, CM | 1 |
| Schetinger, MR | 1 |
| Martínez-Velasco, A | 1 |
| Perez-Ortiz, AC | 1 |
| Antonio-Aguirre, B | 1 |
| Martínez-Villaseñor, L | 1 |
| Lira-Romero, E | 1 |
| Palacio-Pastrana, C | 1 |
| Zenteno, JC | 1 |
| Ramirez, I | 1 |
| Zepeda-Palacio, C | 1 |
| Mendoza-Velásquez, C | 1 |
| Camacho-Ordóñez, A | 1 |
| Ortiz Bibriesca, DM | 1 |
| Estrada-Mena, FJ | 1 |
| Martin, BL | 1 |
| Thompson, LC | 1 |
| Kim, YH | 2 |
| Snow, SJ | 1 |
| Schladweiler, MC | 1 |
| Phillips, P | 1 |
| Harmon, M | 1 |
| King, C | 1 |
| Richards, J | 1 |
| George, I | 1 |
| Haykal-Coates, N | 1 |
| Gilmour, MI | 1 |
| Kodavanti, UP | 1 |
| Hazari, MS | 1 |
| Farraj, AK | 1 |
| Shen, Z | 1 |
| Zou, Y | 1 |
| Gao, K | 1 |
| Lazar, S | 1 |
| Wurtzel, JGT | 1 |
| Ma, P | 1 |
| Goldfinger, LE | 1 |
| Vukelic, M | 1 |
| Laloo, A | 1 |
| Kyttaris, VC | 1 |
| Chen, R | 1 |
| Chen, J | 3 |
| Xun, J | 1 |
| Huang, Q | 2 |
| Steinhart, C | 1 |
| Shen, Y | 1 |
| Lu, H | 2 |
| Mansuri, A | 1 |
| Lokhande, K | 1 |
| Kore, S | 1 |
| Gaikwad, S | 1 |
| Nawani, N | 1 |
| Swamy, KV | 1 |
| Junnarkar, M | 1 |
| Pawar, S | 1 |
| Shaheen, MY | 1 |
| Basudan, AM | 1 |
| Niazy, AA | 1 |
| van den Beucken, JJJP | 1 |
| Jansen, JA | 1 |
| Alghamdi, HS | 1 |
| Gao, Q | 2 |
| Guo, X | 1 |
| Cao, Y | 1 |
| Jia, X | 1 |
| Xu, S | 1 |
| Lu, C | 2 |
| Zhu, H | 2 |
| Melku, M | 1 |
| Abebe, G | 1 |
| Teketel, A | 1 |
| Asrie, F | 1 |
| Yalew, A | 1 |
| Biadgo, B | 1 |
| Kassa, E | 1 |
| Damtie, D | 1 |
| Anlay, DZ | 1 |
| Ahmed, MFE | 1 |
| Ramadan, H | 1 |
| Seinige, D | 1 |
| Kehrenberg, C | 1 |
| Abd El-Wahab, A | 1 |
| Volkmann, N | 1 |
| Kemper, N | 1 |
| Schulz, J | 1 |
| Hu, MY | 1 |
| Wu, YN | 1 |
| McEvoy, MP | 1 |
| Wang, YF | 1 |
| Cong, WL | 1 |
| Liu, LP | 1 |
| Li, XX | 1 |
| Zhou, CL | 1 |
| Chen, WM | 1 |
| Wei, KL | 1 |
| Tung, SY | 1 |
| Shen, CH | 1 |
| Chang, TS | 1 |
| Yen, CW | 1 |
| Hsieh, YY | 1 |
| Chiu, WN | 1 |
| Hu, JH | 1 |
| Lu, SN | 1 |
| Hung, CH | 1 |
| Alakavuklar, MA | 1 |
| Fuqua, C | 1 |
| Luo, KL | 1 |
| Underwood, RS | 1 |
| Greenwald, I | 1 |
| Elashiry, MM | 1 |
| Elashiry, M | 1 |
| Zeitoun, R | 1 |
| Elsayed, R | 1 |
| Tian, F | 1 |
| Saber, SE | 1 |
| Elashry, SH | 1 |
| Tay, FR | 1 |
| Cutler, CW | 1 |
| O'Dowd, A | 1 |
| Maciel, M | 1 |
| Poole, ST | 1 |
| Jobling, MG | 1 |
| Rollenhagen, JE | 1 |
| Woods, CM | 1 |
| Sincock, SA | 1 |
| McVeigh, AL | 1 |
| Gregory, MJ | 1 |
| Maves, RC | 1 |
| Prouty, MG | 1 |
| Holmes, RK | 1 |
| Savarino, SJ | 1 |
| Mor, MK | 1 |
| Palevsky, PM | 1 |
| Kaufman, JS | 1 |
| Thiessen Philbrook, H | 1 |
| Weisbord, SD | 1 |
| Parikh, CR | 1 |
| John, CM | 1 |
| Phillips, NJ | 1 |
| Jarvis, GA | 1 |
| Zhu, Y | 1 |
| Kilburn, S | 1 |
| Kapoor, M | 1 |
| Chaturvedi, S | 1 |
| Shaw, KJ | 1 |
| Chaturvedi, V | 1 |
| Kong, X | 1 |
| Zhang, T | 2 |
| Xiao, H | 1 |
| Feng, X | 1 |
| Tu, H | 1 |
| Feng, J | 1 |
| Sabet, M | 1 |
| Tarazi, Z | 1 |
| Griffith, DC | 1 |
| Nguyen, F | 1 |
| Guan, P | 1 |
| Guerrero, DT | 1 |
| Kolla, V | 1 |
| Naraparaju, K | 1 |
| Perry, LM | 1 |
| Soberman, D | 1 |
| Pressly, BB | 1 |
| Alferiev, IS | 1 |
| Chorny, M | 1 |
| Brodeur, GM | 1 |
| Gao, X | 2 |
| Cheng, YH | 1 |
| Enten, GA | 1 |
| DeSantis, AJ | 1 |
| Gaponenko, V | 1 |
| Majetschak, M | 1 |
| Kim, DY | 1 |
| Choi, MJ | 1 |
| Ko, TK | 1 |
| Lee, NH | 1 |
| Kim, OH | 1 |
| Cheon, HG | 1 |
| Cai, H | 1 |
| Yip, V | 1 |
| Lee, MV | 1 |
| Wong, S | 1 |
| Saad, O | 1 |
| Ma, S | 1 |
| Ljumanovic, N | 1 |
| Khojasteh, SC | 1 |
| Kamath, AV | 1 |
| Shen, BQ | 1 |
| Cuypers, ML | 1 |
| Chanteux, H | 1 |
| Gillent, E | 1 |
| Bonnaillie, P | 1 |
| Saunders, K | 1 |
| Beckers, C | 1 |
| Delatour, C | 1 |
| Dell'Aiera, S | 1 |
| Ungell, AL | 1 |
| Nicolaï, J | 1 |
| Knapp, AK | 1 |
| Chen, A | 1 |
| Griffin-Nolan, RJ | 1 |
| Baur, LE | 1 |
| Carroll, CJW | 1 |
| Gray, JE | 1 |
| Hoffman, AM | 1 |
| Li, X | 6 |
| Post, AK | 1 |
| Slette, IJ | 1 |
| Collins, SL | 1 |
| Luo, Y | 1 |
| Smith, MD | 1 |
| Temitayo, GI | 1 |
| Olawande, B | 1 |
| Emmanuel, YO | 1 |
| Timothy, AT | 1 |
| Kehinde, O | 1 |
| Susan, LF | 1 |
| Ezra, L | 1 |
| Joseph, OO | 1 |
| Lev, S | 1 |
| Desmarini, D | 1 |
| Liuwantara, D | 1 |
| Sorrell, TC | 1 |
| Hawthorne, WJ | 1 |
| Djordjevic, JT | 1 |
| Verso, MG | 1 |
| Costantino, C | 1 |
| Marrella, A | 1 |
| Immordino, P | 1 |
| Vitale, F | 1 |
| Amodio, E | 1 |
| Wang, YD | 1 |
| Yao, WL | 1 |
| Xin, ZM | 1 |
| Han, TT | 1 |
| Wang, ZG | 1 |
| Chen, L | 1 |
| Cai, C | 1 |
| Ba, D | 1 |
| Wen, S | 1 |
| Tian, Q | 1 |
| Lv, W | 1 |
| Cheng, G | 1 |
| Yue, XY | 1 |
| Chu, WJ | 1 |
| Chen, Q | 1 |
| Choi, ES | 1 |
| Zhou, HD | 1 |
| Sun, XF | 1 |
| Sharma, S | 2 |
| Chhoker, S | 1 |
| Xie, C | 1 |
| Ong, EWY | 1 |
| Tan, ZK | 1 |
| Evans, S | 1 |
| Weinheimer, CJ | 1 |
| Kovacs, A | 1 |
| Williams, JW | 1 |
| Randolph, GJ | 1 |
| Jiang, W | 1 |
| Barger, PM | 1 |
| Mann, DL | 1 |
| Huang, Y | 1 |
| Kong, L | 1 |
| Yu, X | 1 |
| Feng, B | 1 |
| Liu, D | 1 |
| Zhao, B | 1 |
| Mendes, GC | 1 |
| Yuan, P | 1 |
| Ge, D | 1 |
| Wang, WM | 1 |
| Fontes, EPB | 1 |
| Li, P | 1 |
| Shan, L | 1 |
| He, P | 1 |
| Katoh, T | 1 |
| Sengoku, T | 1 |
| Hirata, K | 1 |
| Ogata, K | 1 |
| Suga, H | 1 |
| Shun, C | 1 |
| Yong-Yi, J | 1 |
| Mei-Li, C | 1 |
| Shi-Li, L | 1 |
| Jian-Bo, Z | 1 |
| Dan-Li, W | 1 |
| Zhi-Min, G | 1 |
| Ibrahim, AM | 1 |
| Zakhary, SY | 1 |
| Amin, SAW | 1 |
| Ugurlu, M | 1 |
| Fornari, VJ | 1 |
| Hartmann, MSM | 1 |
| Vanni, JR | 1 |
| Rodriguez, R | 1 |
| Langaro, MC | 1 |
| Pelepenko, LE | 1 |
| Zaia, AA | 1 |
| Nakanjako, D | 1 |
| Zalwango, F | 1 |
| Wairagala, P | 1 |
| Luboga, F | 1 |
| Andia Biraro, I | 1 |
| Bukirwa, VD | 1 |
| Mboowa, MG | 1 |
| Cose, S | 1 |
| Seeley, J | 1 |
| Elliott, A | 1 |
| Sun, P | 1 |
| Hao, S | 1 |
| Qu, G | 1 |
| Xing, Y | 1 |
| Xu, X | 2 |
| Maierhofer, M | 1 |
| Rieger, V | 1 |
| Mayr, T | 1 |
| Liu, Y | 3 |
| Zhang, Q | 1 |
| Bigliardi, AP | 1 |
| Fernandes, CLF | 1 |
| Pinto, EA | 1 |
| Dos Santos, M | 1 |
| Garcia, EM | 1 |
| Baisch, PRM | 1 |
| Soares, MCF | 1 |
| Muccillo-Baisch, AL | 1 |
| da Silva Júnior, FMR | 1 |
| Yu, W | 1 |
| Ju, C | 1 |
| Wang, K | 1 |
| Zheng, Z | 1 |
| Liu, H | 3 |
| Martínez-Navarro, EM | 1 |
| Cebrián-Tarancón, C | 1 |
| Moratalla-López, N | 1 |
| Lorenzo, C | 1 |
| Alonso, GL | 1 |
| Salinas, RM | 1 |
| Bermúdez de Castro, JM | 1 |
| Modesto-Mata, M | 1 |
| Martín-Francés, L | 1 |
| García-Campos, C | 1 |
| Martínez de Pinillos, M | 1 |
| Martinón-Torres, M | 1 |
| Hasani, M | 1 |
| Wu, F | 2 |
| Warriner, K | 1 |
| Kurz, M | 1 |
| Gretzke, D | 1 |
| Hörlein, R | 1 |
| Turpault, S | 1 |
| Atzrodt, J | 1 |
| Derdau, V | 1 |
| Yao, Y | 1 |
| Ou, X | 1 |
| Tian, B | 1 |
| Jin, S | 1 |
| Jiang, Z | 1 |
| Zhou, Z | 2 |
| Liu, M | 3 |
| Jiang, GD | 1 |
| Mou, LH | 1 |
| Chen, JJ | 1 |
| Li, ZY | 1 |
| He, SG | 1 |
| Reale, E | 1 |
| Fustinoni, S | 1 |
| Mercadante, R | 1 |
| Polledri, E | 1 |
| Hopf, NB | 1 |
| Grant, PC | 1 |
| Levy, K | 1 |
| Lattimer, TA | 1 |
| Depner, RM | 1 |
| Kerr, CW | 1 |
| Sato, J | 1 |
| Merenda, MEZ | 1 |
| Uemoto, AT | 1 |
| Dos Santos, MP | 1 |
| Barion, MRL | 1 |
| Carciofi, AC | 1 |
| de Paula Dorigam, JC | 1 |
| Ribeiro, LB | 1 |
| Vasconcellos, RS | 1 |
| Waller, SB | 1 |
| Peter, CM | 1 |
| Hoffmann, JF | 1 |
| Cleff, MB | 1 |
| Faria de, RO | 1 |
| Zani, JL | 1 |
| Martins, BA | 1 |
| Sande, D | 1 |
| Solares, MD | 1 |
| Takahashi, JA | 1 |
| Yang, S | 2 |
| Jia, Y | 1 |
| Yin, C | 1 |
| Zhao, R | 1 |
| Ojha, M | 1 |
| Wu, B | 1 |
| Deepa, M | 1 |
| Mo, J | 1 |
| Au, DW | 1 |
| Wan, MT | 1 |
| Shi, J | 1 |
| Zhang, G | 2 |
| Winkler, C | 1 |
| Kong, RY | 1 |
| Seemann, F | 1 |
| Bianco, M | 1 |
| Calvano, CD | 1 |
| Ventura, G | 1 |
| Bianco, G | 1 |
| Losito, I | 1 |
| Cataldi, TRI | 1 |
| Angiolella, L | 1 |
| Staudt, A | 1 |
| Duarte, PF | 1 |
| Amaral, BPD | 1 |
| Peixoto Andrade, BCO | 1 |
| Simas, NK | 1 |
| Correa Ramos Leal, I | 1 |
| Sangenito, LS | 1 |
| Santos, ALSD | 1 |
| de Oliveira, D | 1 |
| Junges, A | 1 |
| Cansian, RL | 1 |
| Paroul, N | 1 |
| Siu, J | 1 |
| Klingler, L | 1 |
| Hung, CT | 1 |
| Jeong, SH | 1 |
| Smith, S | 1 |
| Tingle, MD | 1 |
| Wagner Mackenzie, B | 1 |
| Biswas, K | 1 |
| Douglas, RG | 1 |
| Oza, AM | 1 |
| Lorusso, D | 1 |
| Aghajanian, C | 1 |
| Oaknin, A | 1 |
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| Tanaka, K | 1 |
| Ohishi, K | 1 |
| Akuzawa, S | 1 |
| Fujie, M | 1 |
| Hiranuma, S | 1 |
| Noda, Y | 1 |
| Koike, Y | 1 |
| Nakamura, T | 1 |
| Kume, T | 1 |
| Katsuki, H | 1 |
| Niidome, T | 1 |
| Sugimoto, H | 1 |
| Akaike, A | 1 |
| Watanabe, T | 2 |
| Masaki, Y | 1 |
| Kumano, K | 1 |
| He, N | 1 |
| Suyama, I | 1 |
| Endo, T | 1 |
| Tanaka, N | 1 |
| Yuki, S | 1 |
| Mitsuka, M | 1 |
| Saito, KI | 1 |
| Kogure, K | 1 |
| Nakashima, M | 1 |
| Niwa, M | 1 |
| Iwai, T | 1 |
| Uematsu, T | 1 |
| Wu, TW | 1 |
| Zeng, LH | 1 |
| Fung, KP | 1 |
| Jin, YJ | 1 |
| Mima, T | 1 |
| Raicu, V | 1 |
| Park, KC | 1 |
| Shimizu, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Randomized Open-Label Comparison Study on the Efficacy and Safety of Argatroban Monotherapy With Argatroban-Edaravone Combination Therapy[NCT00153946] | Phase 4 | 814 participants (Actual) | Interventional | 2004-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for edaravone and Reperfusion Injury
2 trials available for edaravone and Reperfusion Injury
| Article | Year |
|---|---|
Deep Learning Reconstruction Algorithm-Based MRI Image Evaluation of Edaravone in the Treatment of Lower Limb Ischemia-Reperfusion Injury.
Topics: Algorithms; Deep Learning; Edaravone; Humans; Lower Extremity; Magnetic Resonance Imaging; Proto-Onc | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
91 other studies available for edaravone and Reperfusion Injury
| Article | Year |
|---|---|
Discovery of a potential anti-ischemic stroke agent: 3-pentylbenzo[c]thiophen-1(3H)-one.
Topics: Animals; Antioxidants; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Fibrinolytic Agents; Fr | 2012 |
The Discovery of Novel ACA Derivatives as Specific TRPM2 Inhibitors that Reduce Ischemic Injury Both In Vitro and In Vivo.
Topics: Animals; Cell Line, Tumor; Cinnamates; Glucose; HEK293 Cells; Humans; Infarction, Middle Cerebral Ar | 2021 |
Effect of Edaravone on MicroRNA Expression in Exosomes after Hepatic Ischemia-reperfusion Injury.
Topics: Animals; Edaravone; Exosomes; Liver; MicroRNAs; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2022 |
Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO-1 signaling pathway in mice.
Topics: Animals; Antioxidants; Apoptosis; Brain Ischemia; Edaravone; Heme Oxygenase-1; Inflammation; Membran | 2022 |
Edaravone Ameliorates Cerebral Ischemia-Reperfusion Injury by Downregulating Ferroptosis via the Nrf2/FPN Pathway in Rats.
Topics: Animals; Brain Ischemia; Cation Transport Proteins; Edaravone; Ferroptosis; Glutathione; Infarction, | 2022 |
Influences of Edaravone on Necroptosis-Related Proteins and Oxidative Stress in Rats with Lower Extremity Ischemia/Reperfusion Injury.
Topics: Animals; Apoptosis; Disease Models, Animal; Edaravone; Interleukin-6; Ischemia; Oxidative Stress; Ra | 2022 |
Influences of Edaravone on Necroptosis-Related Proteins and Oxidative Stress in Rats with Lower Extremity Ischemia/Reperfusion Injury.
Topics: Animals; Apoptosis; Disease Models, Animal; Edaravone; Interleukin-6; Ischemia; Oxidative Stress; Ra | 2022 |
Influences of Edaravone on Necroptosis-Related Proteins and Oxidative Stress in Rats with Lower Extremity Ischemia/Reperfusion Injury.
Topics: Animals; Apoptosis; Disease Models, Animal; Edaravone; Interleukin-6; Ischemia; Oxidative Stress; Ra | 2022 |
Influences of Edaravone on Necroptosis-Related Proteins and Oxidative Stress in Rats with Lower Extremity Ischemia/Reperfusion Injury.
Topics: Animals; Apoptosis; Disease Models, Animal; Edaravone; Interleukin-6; Ischemia; Oxidative Stress; Ra | 2022 |
Development of Edaravone Ionic Liquids and Their Application for the Treatment of Cerebral Ischemia/Reperfusion Injury.
Topics: Animals; Antipyrine; Brain Ischemia; Edaravone; Free Radical Scavengers; Ionic Liquids; Ischemic Str | 2023 |
Edaravone attenuates lung injury in a hind limb ischemia-reperfusion rat model: A histological, immunohistochemical and biochemical study.
Topics: Animals; Biochemical Phenomena; Disease Models, Animal; Edaravone; Electron Transport Complex IV; Hi | 2020 |
Effects of Edaravone on Nitric Oxide, Hydroxyl Radicals and Neuronal Nitric Oxide Synthase During Cerebral Ischemia and Reperfusion in Mice.
Topics: Animals; Brain; Brain Ischemia; Disease Models, Animal; Edaravone; Free Radical Scavengers; Hydroxyl | 2020 |
Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model.
Topics: Animals; Apoptosis; Cardiopulmonary Resuscitation; Disease Models, Animal; Down-Regulation; Edaravon | 2020 |
Oxidative stress evaluation of skeletal muscle in ischemia-reperfusion injury using enhanced magnetic resonance imaging.
Topics: Animals; Disease Models, Animal; Edaravone; Free Radical Scavengers; Magnetic Resonance Imaging; Mal | 2020 |
Edaravone alleviates cell apoptosis and mitochondrial injury in ischemia-reperfusion-induced kidney injury via the JAK/STAT pathway.
Topics: Animals; Apoptosis; Edaravone; Free Radical Scavengers; Janus Kinases; Male; Mitochondria; Rats; Rat | 2020 |
Protective effects of combined treatment with mild hypothermia and edaravone against cerebral ischemia/reperfusion injury via oxidative stress and Nrf2 pathway regulation.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Combined Modality Therapy; Disease Models, Animal; | 2020 |
Protective effect of edaravone against radiation-induced ovarian injury: a histopathological and immunohistochemical evaluation in an experimental rat model.
Topics: Animals; Disease Models, Animal; Edaravone; Female; Free Radical Scavengers; Ovary; Radiation Injuri | 2021 |
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Cell Line; Cell Line, Tumor; Drug Design; Edaravone | 2021 |
NADPH is superior to NADH or edaravone in ameliorating metabolic disturbance and brain injury in ischemic stroke.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Infarction, Middle Cer | 2022 |
Edaravone protects the retina against ischemia/reperfusion‑induced oxidative injury through the PI3K/Akt/Nrf2 pathway.
Topics: Animals; Antioxidants; Antipyrine; Cell Membrane; Cell Survival; Edaravone; Gene Expression Regulati | 2017 |
Edaravone, a free radical scavenger, protects neuronal cells' mitochondria from ischemia by inactivating another new critical factor of the 5-lipoxygenase pathway affecting the arachidonic acid metabolism.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Brain Ischemia; Caffeic Acids; Cell Death; C | 2018 |
Edaravone inhibits autophagy after neuronal oxygen-glucose deprivation/recovery injury.
Topics: Animals; Autophagy; Cells, Cultured; Edaravone; Female; Fetus; Glucose; Humans; Neurons; Neuroprotec | 2019 |
Effects of edaravone on cerebral ischemia-reperfusion in mice through the TLR4/NF-κB/TNF-α pathway.
Topics: Animals; Brain Ischemia; Edaravone; Free Radical Scavengers; Mice; Neuroprotective Agents; NF-kappa | 2021 |
Protective effect of edaravone for tourniquet-induced ischemia-reperfusion injury on skeletal muscle in murine hindlimb.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Hindlimb; Male; Mice; Mice, Inbred C57BL; M | 2013 |
Attenuation of ischemia/reperfusion-induced ovarian damage in rats: does edaravone offer protection?
Topics: Animals; Antipyrine; Caspase 3; Edaravone; Female; Free Radical Scavengers; Glutathione; Immunohisto | 2013 |
Edaravone, a free radical scavenger, improves the graft viability on liver transplantation from non-heart-beating donors in pigs.
Topics: Adenosine; Allopurinol; Animals; Antipyrine; Biomarkers; Cold Ischemia; Cytoprotection; Edaravone; F | 2014 |
Edaravone prevents lung injury induced by hepatic ischemia-reperfusion.
Topics: Acute Lung Injury; Alanine Transaminase; Animals; Antipyrine; Aspartate Aminotransferases; Cytokines | 2015 |
A nitric oxide-donor furoxan moiety improves the efficacy of edaravone against early renal dysfunction and injury evoked by ischemia/reperfusion.
Topics: Acetylglucosamine; Acute-Phase Proteins; Animals; Antipyrine; Creatinine; Disease Models, Animal; Ed | 2015 |
The free-radical scavenger edaravone accelerates thrombolysis with alteplase in an experimental thrombosis model.
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Fibrinolysis; Fibrinolytic Agents; Free Radi | 2015 |
[Protective effect of novel edaravone and danshensu conjugate on focal cerebral ischemia-reperfusion injury
in rats and its underlying mechanism].
Topics: Animals; Antipyrine; Brain Edema; Brain Ischemia; Cerebral Infarction; Edaravone; Lactates; Malondia | 2015 |
Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent.
Topics: Animals; Antioxidants; Antipyrine; Behavior, Animal; Benzofurans; Biological Availability; Brain; Ca | 2015 |
Edaravone enhances the viability of ischemia/reperfusion flaps.
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Graft Survival; Ischemic Preconditioning; Ma | 2017 |
[Protective effects of edaravone on renal ischemia-reperfusion injury in rats].
Topics: Animals; Antipyrine; Edaravone; Kidney; Male; Malondialdehyde; Random Allocation; Rats; Rats, Spragu | 2008 |
Edaravone (MCI-186), a free radical scavenger, attenuates retinal ischemia/reperfusion injury in rats.
Topics: Animals; Antipyrine; Apoptosis; Edaravone; Electroretinography; Free Radical Scavengers; In Situ Nic | 2008 |
A free radical scavenger, edaravone, prevents ischemia-reperfusion injury in liver grafts from non-heart-beating donors.
Topics: Animals; Antipyrine; Aspartate Aminotransferases; Bile; Cadaver; Edaravone; Free Radical Scavengers; | 2008 |
Pretreatment with edaravone reduces lung mitochondrial damage in an infant rabbit ischemia-reperfusion model.
Topics: Acute Lung Injury; Animals; Animals, Suckling; Antipyrine; Constriction; Disease Models, Animal; Eda | 2008 |
Edaravone attenuates ischemia-reperfusion injury by inhibiting oxidative stress in a canine lung transplantation model.
Topics: Animals; Antipyrine; Disease Models, Animal; Dogs; Edaravone; Lipid Peroxidation; Lung; Lung Transpl | 2008 |
[A comparison of protective effect of propofol and edaravone pretreatment against cerebral ischemia-reperfusion injury].
Topics: Animals; Antipyrine; Apoptosis; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Cortex; Eda | 2008 |
Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
Topics: Animals; Antipyrine; Blood Pressure; Blotting, Western; Brain Ischemia; Cells, Cultured; Cerebral He | 2009 |
Edaravone prevents bowel infarction after acute superior mesenteric artery thromboembolism using autologous fibrin clots in a rabbit model.
Topics: Animals; Anticoagulants; Antipyrine; Case-Control Studies; Disease Models, Animal; Edaravone; Fibrin | 2009 |
Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: in vitro study of isolated rat heart.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Heart; Heart Arrest, Induced; In Vitro Tech | 2009 |
Does the concomitant intra-arterial injection of asialoerythropoietin and edaravone mitigate ischaemic mucosal damage after acute superior mesenteric artery thromboembolism in a rabbit autologous fibrin clot model?
Topics: Animals; Antipyrine; Asialoglycoproteins; Catheterization; Disease Models, Animal; Drug Combinations | 2010 |
Changes of expression of glucose transporters in the fetal lamb brain after MCI-186 administration to the maternal circulation with 10-min persistent umbilical cord occlusion.
Topics: Animals; Antipyrine; Arterial Occlusive Diseases; Brain; Drug Evaluation, Preclinical; Edaravone; Fe | 2009 |
Effect of the free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury.
Topics: Animals; Antipyrine; Behavior, Animal; Edaravone; Edema; Electrophysiology; Free Radical Scavengers; | 2009 |
Protective effect of edaravone, a free-radical scavenger, on ischaemia-reperfusion injury in the rat testis.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Male; Oxidative Stress; Rats; Rats, Sprague | 2010 |
Effect of edaravone on ischemia/reperfusion injury in rat urinary bladder--changes in smooth muscle cell phenotype and contractile function.
Topics: Animals; Antipyrine; Dose-Response Relationship, Drug; Edaravone; Electric Stimulation; Free Radical | 2010 |
[A comparative study on the protection effect of nerve growth factor and edaravone pretreatment against cerebral ischemia/reperfusion injury].
Topics: Animals; Animals, Newborn; Antipyrine; Apoptosis; Brain Ischemia; Cells, Cultured; Disease Models, A | 2010 |
A novel rodent model of reperfusion injury following occlusion of the middle cerebral artery.
Topics: Animals; Antipyrine; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship | 2010 |
Protective effect of edaravone against renal ischemia/reperfusion injury and compared with ischemic postconditioning in rats.
Topics: Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Blood Urea Nitrogen; Creatinine; Edaravo | 2010 |
Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation.
Topics: Abietanes; Antioxidants; Antipyrine; Astrocytes; Cell Survival; Cells, Cultured; Drug Synergism; Eda | 2011 |
A somatostatin analogue, octreotide, ameliorates intestinal ischemia-reperfusion injury through the early induction of heme oxygenase-1.
Topics: Animals; Antipyrine; Edaravone; Enzyme Inhibitors; Free Radical Scavengers; Heme Oxygenase-1; Intest | 2012 |
New method for absolute spinal cord ischemia protection in rabbits.
Topics: Animals; Antipyrine; Aorta; Biomarkers; Combined Modality Therapy; Constriction; Disease Models, Ani | 2011 |
Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina.
Topics: Animals; Antipyrine; Blood Flow Velocity; Carotid Artery, External; Cell Count; Cerebrovascular Circ | 2011 |
Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury.
Topics: Analysis of Variance; Animals; Antipyrine; Bromodeoxyuridine; Cerebral Infarction; Cerebral Ventricl | 2012 |
The effect of edaravone on ischemia-reperfusion injury in rat ovary.
Topics: Animals; Antipyrine; Edaravone; Female; Free Radical Scavengers; Ovarian Diseases; Ovary; Postoperat | 2012 |
[Neuroprotective effects of combined pretreatment with edaravone and propofol on neonatal rat cerebral cortical neurons with ischemia/reperfusion injury in vitro].
Topics: Animals; Antipyrine; Apoptosis; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Cortex; Eda | 2012 |
Edaravone inhibits apoptosis caused by ischemia/reperfusion injury in a porcine hepatectomy model.
Topics: Animals; Antipyrine; Apoptosis; Biomarkers; Cytoprotection; Disease Models, Animal; Edaravone; Free | 2012 |
Beneficial effect of MCI-186 on hepatic warm ischemia-reperfusion in the rat.
Topics: Animals; Antipyrine; Apoptosis; Edaravone; Free Radical Scavengers; In Situ Nick-End Labeling; Ische | 2002 |
Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver.
Topics: Animals; Antipyrine; Edaravone; Electron Transport; Free Radical Scavengers; Glutathione Peroxidase; | 2003 |
Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger.
Topics: Animals; Antipyrine; Edaravone; Enzyme Inhibitors; Free Radical Scavengers; Infarction, Middle Cereb | 2003 |
Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats.
Topics: Animals; Antipyrine; Cytokines; Edaravone; Free Radical Scavengers; Hemoglobins; Intestinal Mucosa; | 2004 |
The hydroxyl radical scavenger MCI-186 protects the liver from experimental cold ischaemia-reperfusion injury.
Topics: Animals; Antipyrine; Cold Temperature; Edaravone; Free Radical Scavengers; Hydroxyl Radical; Interle | 2004 |
Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney.
Topics: Animals; Antipyrine; Cell Line; Edaravone; Free Radical Scavengers; Humans; Kidney; Kidney Tubules, | 2004 |
Protective effect of edaravone against hypoxia-reoxygenation injury in rabbit cardiomyocytes.
Topics: Action Potentials; Animals; Antipyrine; Cell Death; Cells, Cultured; Edaravone; Flow Cytometry; Free | 2004 |
Antioxidant effect of MCI-186, a new Free-Radical scavenger, on ischemia-reperfusion injury in a rat hindlimb amputation model.
Topics: Amputation, Surgical; Animals; Antioxidants; Antipyrine; Body Water; Edaravone; Enzymes; Free Radica | 2004 |
Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat.
Topics: Animals; Antipyrine; Disease Progression; Edaravone; Interleukin-6; Intestines; Ischemia; Lung; Male | 2005 |
Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats.
Topics: Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Brain Edema; Brain Ischemia; Cerebral Co | 2005 |
Maternal treatment with MCI-186 does not improve delayed deterioration of cellular bioenergetic state and mitochondrial activity following transient intrauterine ischemia in the fetal rat brain.
Topics: Animals; Antipyrine; Brain; Brain Ischemia; Edaravone; Energy Metabolism; Female; Fetal Hypoxia; Fre | 2005 |
MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats.
Topics: Alanine Transaminase; Aldehydes; Animals; Antipyrine; Chemokines; Cytokines; Edaravone; Free Radical | 2005 |
A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation.
Topics: Animals; Antipyrine; Dogs; Edaravone; Female; Free Radical Scavengers; Kidney; Kidney Function Tests | 2005 |
Effect of the free radical scavenger MCI-186 on spinal cord reperfusion after transient ischemia in the rabbit.
Topics: Animals; Antipyrine; Cell Death; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavenger | 2005 |
Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Anti-Inflammatory Agents; Antioxidants; Antipyrine; | 2005 |
Edaravone protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Male; Rats; Rats, Sprague-Dawley; Reperfusi | 2005 |
A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia.
Topics: Angiogenesis Inducing Agents; Animals; Antipyrine; Edaravone; Fibroblast Growth Factor 2; Free Radic | 2006 |
Experimental study on the protective effects of edaravone against ischemic spinal cord injury.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Male; Rabbits; Reperfusion Injury; Spinal C | 2005 |
MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation.
Topics: Animals; Antipyrine; Bronchoalveolar Lavage Fluid; Cold Ischemia; Disease Models, Animal; Edaravone; | 2006 |
Edaravone inhibits JNK-c-Jun pathway and restores anti-oxidative defense after ischemia-reperfusion injury in aged rats.
Topics: Aging; Animals; Antioxidants; Antipyrine; Blotting, Western; Brain; Cerebral Infarction; Edaravone; | 2006 |
[Homeostatic conditions affect the protective effect of edaravone on ischemic injury in neurons].
Topics: Animals; Animals, Newborn; Antipyrine; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Edaravone; Gl | 2006 |
Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage.
Topics: Acute Disease; Animals; Antipyrine; Edaravone; Electron Spin Resonance Spectroscopy; Free Radicals; | 2006 |
MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one) attenuated simulated ischemia/reperfusion injury in cultured rat hippocampal cells.
Topics: Animals; Antipyrine; Apoptosis; Calcium; Cells, Cultured; Edaravone; Hippocampus; Malondialdehyde; M | 2006 |
Effect of the free radical scavenger MCI-186 on pulmonary ischemia-reperfusion injury in dogs.
Topics: Animals; Antipyrine; Dogs; Edaravone; Free Radical Scavengers; Lung; Lung Transplantation; Reperfusi | 2006 |
Treatment with edaravone improves the survival rate in renal warm ischemia-reperfusion injury using rat model.
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Male; Rats; Rats, I | 2006 |
Edaravone reduces ischemia-reperfusion injury mediators in rat liver.
Topics: Animals; Antipyrine; Aspartate Aminotransferases; E-Selectin; Edaravone; Free Radical Scavengers; Li | 2007 |
Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction.
Topics: Analysis of Variance; Animals; Antipyrine; Blood Chemical Analysis; Cardiopulmonary Bypass; Cerebral | 2007 |
Effects of edaravone in heart of aged rats after cerebral ischemia-reperfusion injury.
Topics: Aging; Animals; Antipyrine; Apoptosis; Blotting, Western; Brain Ischemia; Cell Survival; Disease Mod | 2007 |
Amelioration of hepatic ischemia/reperfusion injury in the remnant liver after partial hepatectomy in rats.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Gene Expression Regulation; Hepatectomy; In | 2007 |
Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats.
Topics: Animals; Antipyrine; Body Weight; Brain Ischemia; Cerebrovascular Circulation; Diterpenes; Dose-Resp | 2008 |
The novel antioxidant edaravone: from bench to bedside.
Topics: Animals; Anti-Inflammatory Agents; Antipyrine; Drug Evaluation, Preclinical; Edaravone; Free Radical | 2008 |
Protective effects of MCI-186 on cold kidney preservation/reperfusion injury in the rat.
Topics: Animals; Antipyrine; Creatinine; Edaravone; Free Radical Scavengers; Hypertonic Solutions; In Vitro | 1996 |
[In vitro evaluation of metabolic change in forebrain ischemia model of rat using proton magnetic resonance spectroscopy].
Topics: Acetates; Animals; Antipyrine; Brain; Brain Ischemia; Choline; Edaravone; Free Radical Scavengers; L | 1997 |
Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia.
Topics: Animals; Antipyrine; Brain Ischemia; Cell Death; Edaravone; Free Radical Scavengers; Hippocampus; Hy | 1997 |
Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat.
Topics: Animals; Antipyrine; Brain; Caudate Nucleus; Cerebral Infarction; Cyclic N-Oxides; Disease Models, A | 1999 |
MCI-186: further histochemical and biochemical evidence of neuroprotection.
Topics: Animals; Antipyrine; Brain; Brain Infarction; Creatine Kinase; Cytochrome c Group; Edaravone; Free R | 2000 |
Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils.
Topics: Animals; Anticoagulants; Antipyrine; Arginine; Body Water; Brain Edema; Brain Ischemia; Cerebral Inf | 2002 |