edaravone has been researched along with Nerve Degeneration in 9 studies
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effects of edaravone, a free radical scavenger, on peripheral nerve ischemia-reperfusion injury caused by ligation of vessels supplying the sciatic and tibial nerves in rats." | 7.75 | Effect of the free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury. ( Iida, H; Nagasaka, T; Shindo, K; Shiozawa, Z, 2009) |
| "We investigated whether or not a combination of the selective thrombin inhibitor, argatroban, and the free radical scavenger, edaravone (MCI-186), ameliorates postischemic hypoperfusion and decreases mortality after 15 min of forebrain ischemia in the gerbil." | 7.71 | Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. ( Jin, YJ; Mima, T; Park, KC; Raicu, V; Shimizu, K, 2002) |
| "We investigated the effects of edaravone, a free radical scavenger, on peripheral nerve ischemia-reperfusion injury caused by ligation of vessels supplying the sciatic and tibial nerves in rats." | 3.75 | Effect of the free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury. ( Iida, H; Nagasaka, T; Shindo, K; Shiozawa, Z, 2009) |
| "We investigated whether or not a combination of the selective thrombin inhibitor, argatroban, and the free radical scavenger, edaravone (MCI-186), ameliorates postischemic hypoperfusion and decreases mortality after 15 min of forebrain ischemia in the gerbil." | 3.71 | Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. ( Jin, YJ; Mima, T; Park, KC; Raicu, V; Shimizu, K, 2002) |
| "Treatment with edaravone significantly improved STZ-induced cognitive damage as evaluated in Morris water maze and step-down tests and markedly restored changes in malondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE) adducts, hydroxyl radical (OH), hydrogen peroxide (H2O2), total superoxide dismutase (T-SOD), reduced glutathione (GSH), glutathione peroxidase (GPx) and protein carbonyl (PC) levels." | 1.39 | Neuroprotective effects of edaravone on cognitive deficit, oxidative stress and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats. ( Chi, L; Yu, G; Zhang, L; Zhang, W; Zhang, Y; Zhou, S; Zhu, J, 2013) |
| "Oral montelukast (0." | 1.37 | Montelukast, a cysteinyl leukotriene receptor-1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats. ( Fang, SH; Shi, WZ; Wei, EQ; Zhang, YM; Zhao, R, 2011) |
| "Edaravone (Eda) is a potent scavenger of hydroxyl radicals and has been demonstrated to be beneficial for patients with acute ischemic stroke." | 1.35 | Edaravone protects against MPP+ -induced cytotoxicity in rat primary cultured astrocytes via inhibition of mitochondrial apoptotic pathway. ( Chen, H; Ding, JH; Hu, G; Wang, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, S | 1 |
| Yu, G | 1 |
| Chi, L | 1 |
| Zhu, J | 1 |
| Zhang, W | 1 |
| Zhang, Y | 1 |
| Zhang, L | 1 |
| Chen, H | 1 |
| Wang, S | 1 |
| Ding, JH | 1 |
| Hu, G | 1 |
| Iida, H | 1 |
| Nagasaka, T | 1 |
| Shindo, K | 1 |
| Shiozawa, Z | 1 |
| Jiao, L | 1 |
| Zhang, J | 1 |
| Li, Z | 1 |
| Liu, H | 1 |
| Chen, Y | 1 |
| Xu, S | 1 |
| Zhao, R | 1 |
| Shi, WZ | 1 |
| Zhang, YM | 1 |
| Fang, SH | 1 |
| Wei, EQ | 1 |
| Ni, X | 1 |
| Yang, ZJ | 1 |
| Carter, EL | 1 |
| Martin, LJ | 1 |
| Koehler, RC | 1 |
| Noor, JI | 1 |
| Ueda, Y | 1 |
| Ikeda, T | 1 |
| Ikenoue, T | 1 |
| Miyamoto, R | 1 |
| Shimakawa, S | 1 |
| Suzuki, S | 1 |
| Ogihara, T | 1 |
| Tamai, H | 1 |
| Jin, YJ | 1 |
| Mima, T | 1 |
| Raicu, V | 1 |
| Park, KC | 1 |
| Shimizu, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Randomized Open-Label Comparison Study on the Efficacy and Safety of Argatroban Monotherapy With Argatroban-Edaravone Combination Therapy[NCT00153946] | Phase 4 | 814 participants (Actual) | Interventional | 2004-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for edaravone and Nerve Degeneration
| Article | Year |
|---|---|
Neuroprotective effects of edaravone on cognitive deficit, oxidative stress and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats.
Topics: Alzheimer Disease; Animals; Antipyrine; Cognition Disorders; Edaravone; Free Radical Scavengers; Inf | 2013 |
Edaravone protects against MPP+ -induced cytotoxicity in rat primary cultured astrocytes via inhibition of mitochondrial apoptotic pathway.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Antipyrine; Apoptosis; Astrocytes; Brain; Ce | 2008 |
Effect of the free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury.
Topics: Animals; Antipyrine; Behavior, Animal; Edaravone; Edema; Electrophysiology; Free Radical Scavengers; | 2009 |
Edaravone alleviates delayed neuronal death and long-dated cognitive dysfunction of hippocampus after transient focal ischemia in Wistar rat brains.
Topics: Animals; Antipyrine; Brain Ischemia; Cognition Disorders; Disease Models, Animal; Edaravone; Free Ra | 2011 |
Montelukast, a cysteinyl leukotriene receptor-1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats.
Topics: Acetates; Administration, Oral; Animals; Antipyrine; Atrophy; Behavior, Animal; Brain Injury, Chroni | 2011 |
Striatal neuroprotection from neonatal hypoxia-ischemia in piglets by antioxidant treatment with EUK-134 or edaravone.
Topics: Animals; Animals, Newborn; Antioxidants; Antipyrine; Corpus Striatum; Edaravone; Free Radical Scaven | 2011 |
Edaravone inhibits lipid peroxidation in neonatal hypoxic-ischemic rats: an in vivo microdialysis study.
Topics: Animals; Animals, Newborn; Antipyrine; Dose-Response Relationship, Drug; Edaravone; Electron Spin Re | 2007 |
Edaravone prevents kainic acid-induced neuronal death.
Topics: Aldehydes; Animals; Antipyrine; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Edaravon | 2008 |
Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils.
Topics: Animals; Anticoagulants; Antipyrine; Arginine; Body Water; Brain Edema; Brain Ischemia; Cerebral Inf | 2002 |