ed-110 and Ovarian-Neoplasms

ed-110 has been researched along with Ovarian-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for ed-110 and Ovarian-Neoplasms

Article	Year
Indolocarbazole poisons of human topoisomerase I: regioisomeric analogues of ED-110. Bioorganic & medicinal chemistry letters, 1999, Jan-18, Volume: 9, Issue:2 All four "symmetrical" regioisomers of ED-110, an indolocarbazole derivative having potent activity against human topoisomerase I (Topo I) were synthesized. The isomer containing hydroxyl groups in the 3- and 9-positions was approximately ten-fold more active against Topo I, and 5- to 35-fold more active against human solid tumor cell lines in vitro, relative to ED-110. Topics: Antineoplastic Agents; Camptothecin; Carbazoles; Female; Glucosides; HT29 Cells; Humans; Inhibitory Concentration 50; Male; Ovarian Neoplasms; Prostatic Neoplasms; Topoisomerase I Inhibitors; Tumor Cells, Cultured	1999

Article

Year

Indolocarbazole poisons of human topoisomerase I: regioisomeric analogues of ED-110.

Bioorganic & medicinal chemistry letters, 1999, Jan-18, Volume: 9, Issue:2

All four "symmetrical" regioisomers of ED-110, an indolocarbazole derivative having potent activity against human topoisomerase I (Topo I) were synthesized. The isomer containing hydroxyl groups in the 3- and 9-positions was approximately ten-fold more active against Topo I, and 5- to 35-fold more active against human solid tumor cell lines in vitro, relative to ED-110.

Topics: Antineoplastic Agents; Camptothecin; Carbazoles; Female; Glucosides; HT29 Cells; Humans; Inhibitory Concentration 50; Male; Ovarian Neoplasms; Prostatic Neoplasms; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1999