Compounds > ecteinascidin 743
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ecteinascidin 743 and Chemical and Drug Induced Liver Injury

ecteinascidin 743 has been researched along with Chemical and Drug Induced Liver Injury in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (50.00)29.6817
2010's6 (42.86)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Hayakawa, K; Iwata, S; Kobayashi, H; Oka, H; Tanaka, S; Ueda, T; Wakamatsu, T; Wasa, J; Yonemoto, T1
Higuchi, M; Ishiki, H; Kiuchi, D; Satomi, E; Shimizu, M1
Judson, I; Martin-Liberal, J1
Bétrian, S; Chatelut, E; Chevreau, C; Hennebelle, I; Laurenty, AP; Le Guellec, C; Le Guellec, S; Thomas, F1
Le Cesne, A; Reichardt, P1
Nystrom, KK; Pick, AM1
Davies, R; Dinsdale, D; Donald, S; Edwards, R; Gant, TW; Gescher, AJ; Greaves, P; Judah, DJ; Lopez Lazaro, L; Riley, J; Smith, AG; Verschoyle, RD1
Colombo, T; D'Incalci, M; Donald, S; Frapolli, R; Gant, TW; Gescher, AJ; Greaves, P; Jimeno, J; Lopez-Lazaro, L; Meco, D; Riccardi, R; Verschoyle, RD; Zaffaroni, M; Zucchetti, M1
Donald, S; Gescher, AJ; Greaves, P; Jimeno, J; Orr, S; Verschoyle, RD1
Bertulli, R; Casali, PG; D'Incalci, M; Dileo, P; Gescher, A; Grosso, F; Jimeno, J; Piovesan, C; Sanfilippo, R; Stacchiotti, S1
Fetterly, GJ; Izquierdo, MA; Owen, JS; Passarell, JA; Perez-Ruixo, JJ; Soto-Matos, A; Stuyckens, K; Zannikos, P1
Brouwer, KL; Lee, JK; Leslie, EM; Zamek-Gliszczynski, MJ1
Brahmer, J; Donehower, RC; Elsayed, Y; Ettinger, D; Hidalgo, M; Jimeno, A; Khan, Y; Laheru, D; Lansey, D; Messersmith, WA; Zannikos, P1

Reviews

2 review(s) available for ecteinascidin 743 and Chemical and Drug Induced Liver Injury

ArticleYear
Safety evaluation of trabectedin in treatment of soft-tissue sarcomas.
    Expert opinion on drug safety, 2013, Volume: 12, Issue:6

    Topics: Antineoplastic Agents, Alkylating; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Dioxoles; Humans; Rhabdomyolysis; Sarcoma; Tetrahydroisoquinolines; Trabectedin; Treatment Outcome

2013
Optimizing the use of trabectedin for advanced soft tissue sarcoma in daily clinical practice.
    Future oncology (London, England), 2015, Volume: 11, Issue:11 Suppl

    Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chemical and Drug Induced Liver Injury; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dioxoles; Disease Progression; Drug Administration Schedule; Hematologic Diseases; Humans; Infusions, Intravenous; Kaplan-Meier Estimate; Middle Aged; Multicenter Studies as Topic; Palliative Care; Patient Selection; Randomized Controlled Trials as Topic; Salvage Therapy; Sarcoma; Soft Tissue Neoplasms; Tetrahydroisoquinolines; Trabectedin; Translocation, Genetic

2015

Trials

1 trial(s) available for ecteinascidin 743 and Chemical and Drug Induced Liver Injury

ArticleYear
Phase I trial of weekly trabectedin (ET-743) and gemcitabine in patients with advanced solid tumors.
    Cancer chemotherapy and pharmacology, 2008, Volume: 63, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Deoxycytidine; Dioxoles; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gemcitabine; Hematologic Diseases; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Tetrahydroisoquinolines; Trabectedin

2008

Other Studies

11 other study(ies) available for ecteinascidin 743 and Chemical and Drug Induced Liver Injury

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Efficacy and safety of trabectedin for patients with unresectable and relapsed soft-tissue sarcoma in Japan: A Japanese Musculoskeletal Oncology Group study.
    Cancer, 2020, 03-15, Volume: 126, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Agents, Alkylating; Body Height; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Humans; Japan; Male; Middle Aged; Neutropenia; Product Surveillance, Postmarketing; Progression-Free Survival; Retrospective Studies; Rhabdomyolysis; Sarcoma; Soft Tissue Neoplasms; Trabectedin; Young Adult

2020
[A Case of Methadone Induced Drowsiness Following Trabectedin Induced Liver Injury].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2019, Volume: 46, Issue:7

    Topics: Aged; Chemical and Drug Induced Liver Injury; Histiocytoma, Malignant Fibrous; Humans; Liver; Male; Methadone; Pain; Trabectedin

2019
Irreversible hepatotoxicity after administration of trabectedin to a pleiomorphic sarcoma patient with a rare ABCC2 polymorphism: a case report.
    Pharmacogenomics, 2013, Volume: 14, Issue:12

    Topics: Aged; Antineoplastic Agents, Alkylating; Chemical and Drug Induced Liver Injury; Dioxoles; Genotype; Humans; Liver; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Polymorphism, Genetic; Sarcoma; Tetrahydroisoquinolines; Trabectedin

2013
Fatal hepatic and renal toxicity as a complication of trabectedin therapy for radiation-induced sarcoma.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2010, Volume: 16, Issue:4

    Topics: Acute Kidney Injury; Aged; Antineoplastic Agents, Alkylating; Chemical and Drug Induced Liver Injury; Dioxoles; Fatal Outcome; Humans; Liver Failure, Acute; Male; Neoplasms, Radiation-Induced; Sarcoma; Skull Base Neoplasms; Tetrahydroisoquinolines; Trabectedin

2010
Hepatobiliary damage and changes in hepatic gene expression caused by the antitumor drug ecteinascidin-743 (ET-743) in the female rat.
    Cancer research, 2002, Aug-01, Volume: 62, Issue:15

    Topics: Animals; Antineoplastic Agents, Alkylating; Bile Duct Diseases; Bilirubin; Cell Division; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dioxoles; Female; Gene Expression; Isoquinolines; Liver; Liver Diseases; Rats; Rats, Wistar; Tetrahydroisoquinolines; Trabectedin

2002
Complete protection by high-dose dexamethasone against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the rat.
    Cancer research, 2003, Sep-15, Volume: 63, Issue:18

    Topics: Animals; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Dexamethasone; Dioxoles; Down-Regulation; Drug Interactions; Female; Gene Expression; Isoquinolines; Liver; Liver Diseases; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Oligonucleotide Array Sequence Analysis; Oxidoreductases, N-Demethylating; Rats; Rats, Inbred F344; Rats, Wistar; Tetrahydroisoquinolines; Trabectedin

2003
Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro.
    Cancer chemotherapy and pharmacology, 2004, Volume: 53, Issue:4

    Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Antineoplastic Agents, Alkylating; Aspartate Aminotransferases; beta-Naphthoflavone; Cell Survival; Chemical and Drug Induced Liver Injury; Dexamethasone; Dioxoles; Female; Hepatocytes; Inactivation, Metabolic; Isoquinolines; Liver; Phenobarbital; Rats; Rats, Wistar; Tetrahydroisoquinolines; Trabectedin

2004
Steroid premedication markedly reduces liver and bone marrow toxicity of trabectedin in advanced sarcoma.
    European journal of cancer (Oxford, England : 1990), 2006, Volume: 42, Issue:10

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Dioxoles; Disease-Free Survival; Female; Humans; Liver Diseases; Male; Middle Aged; Premedication; Sarcoma; Steroids; Tetrahydroisoquinolines; Trabectedin

2006
Semimechanistic pharmacokinetic/pharmacodynamic model for hepatoprotective effect of dexamethasone on transient transaminitis after trabectedin (ET-743) treatment.
    Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Algorithms; Analysis of Variance; Anti-Inflammatory Agents; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Computer Simulation; Data Interpretation, Statistical; Dexamethasone; Dioxoles; Drug Tolerance; Female; Finite Element Analysis; Humans; Intercalating Agents; Male; Middle Aged; Models, Statistical; Software; Tetrahydroisoquinolines; Trabectedin; Transaminases

2008
Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity.
    Toxicology and applied pharmacology, 2008, Apr-01, Volume: 228, Issue:1

    Topics: Animals; Animals, Genetically Modified; Anti-Inflammatory Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Bile; Blotting, Western; Buthionine Sulfoximine; Cell Separation; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dexamethasone; Dioxoles; Enzyme Inhibitors; Hepatocytes; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Rats; Rats, Wistar; Tetrahydroisoquinolines; Trabectedin

2008