Compounds > ecteinascidin 743
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ecteinascidin 743 and Acute Liver Injury, Drug-Induced

ecteinascidin 743 has been researched along with Acute Liver Injury, Drug-Induced in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (50.00)29.6817
2010's6 (42.86)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Hayakawa, K; Iwata, S; Kobayashi, H; Oka, H; Tanaka, S; Ueda, T; Wakamatsu, T; Wasa, J; Yonemoto, T1
Higuchi, M; Ishiki, H; Kiuchi, D; Satomi, E; Shimizu, M1
Judson, I; Martin-Liberal, J1
Bétrian, S; Chatelut, E; Chevreau, C; Hennebelle, I; Laurenty, AP; Le Guellec, C; Le Guellec, S; Thomas, F1
Le Cesne, A; Reichardt, P1
Nystrom, KK; Pick, AM1
Davies, R; Dinsdale, D; Donald, S; Edwards, R; Gant, TW; Gescher, AJ; Greaves, P; Judah, DJ; Lopez Lazaro, L; Riley, J; Smith, AG; Verschoyle, RD1
Colombo, T; D'Incalci, M; Donald, S; Frapolli, R; Gant, TW; Gescher, AJ; Greaves, P; Jimeno, J; Lopez-Lazaro, L; Meco, D; Riccardi, R; Verschoyle, RD; Zaffaroni, M; Zucchetti, M1
Donald, S; Gescher, AJ; Greaves, P; Jimeno, J; Orr, S; Verschoyle, RD1
Bertulli, R; Casali, PG; D'Incalci, M; Dileo, P; Gescher, A; Grosso, F; Jimeno, J; Piovesan, C; Sanfilippo, R; Stacchiotti, S1
Fetterly, GJ; Izquierdo, MA; Owen, JS; Passarell, JA; Perez-Ruixo, JJ; Soto-Matos, A; Stuyckens, K; Zannikos, P1
Brouwer, KL; Lee, JK; Leslie, EM; Zamek-Gliszczynski, MJ1
Brahmer, J; Donehower, RC; Elsayed, Y; Ettinger, D; Hidalgo, M; Jimeno, A; Khan, Y; Laheru, D; Lansey, D; Messersmith, WA; Zannikos, P1

Reviews

2 review(s) available for ecteinascidin 743 and Acute Liver Injury, Drug-Induced

ArticleYear
Safety evaluation of trabectedin in treatment of soft-tissue sarcomas.
    Expert opinion on drug safety, 2013, Volume: 12, Issue:6

    Topics: Antineoplastic Agents, Alkylating; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Dioxoles; Humans; Rhabdomyolysis; Sarcoma; Tetrahydroisoquinolines; Trabectedin; Treatment Outcome

2013
Optimizing the use of trabectedin for advanced soft tissue sarcoma in daily clinical practice.
    Future oncology (London, England), 2015, Volume: 11, Issue:11 Suppl

    Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chemical and Drug Induced Liver Injury; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dioxoles; Disease Progression; Drug Administration Schedule; Hematologic Diseases; Humans; Infusions, Intravenous; Kaplan-Meier Estimate; Middle Aged; Multicenter Studies as Topic; Palliative Care; Patient Selection; Randomized Controlled Trials as Topic; Salvage Therapy; Sarcoma; Soft Tissue Neoplasms; Tetrahydroisoquinolines; Trabectedin; Translocation, Genetic

2015

Trials

1 trial(s) available for ecteinascidin 743 and Acute Liver Injury, Drug-Induced

ArticleYear
Phase I trial of weekly trabectedin (ET-743) and gemcitabine in patients with advanced solid tumors.
    Cancer chemotherapy and pharmacology, 2008, Volume: 63, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Deoxycytidine; Dioxoles; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gemcitabine; Hematologic Diseases; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Tetrahydroisoquinolines; Trabectedin

2008

Other Studies

11 other study(ies) available for ecteinascidin 743 and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Efficacy and safety of trabectedin for patients with unresectable and relapsed soft-tissue sarcoma in Japan: A Japanese Musculoskeletal Oncology Group study.
    Cancer, 2020, 03-15, Volume: 126, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Agents, Alkylating; Body Height; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Humans; Japan; Male; Middle Aged; Neutropenia; Product Surveillance, Postmarketing; Progression-Free Survival; Retrospective Studies; Rhabdomyolysis; Sarcoma; Soft Tissue Neoplasms; Trabectedin; Young Adult

2020
[A Case of Methadone Induced Drowsiness Following Trabectedin Induced Liver Injury].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2019, Volume: 46, Issue:7

    Topics: Aged; Chemical and Drug Induced Liver Injury; Histiocytoma, Malignant Fibrous; Humans; Liver; Male; Methadone; Pain; Trabectedin

2019
Irreversible hepatotoxicity after administration of trabectedin to a pleiomorphic sarcoma patient with a rare ABCC2 polymorphism: a case report.
    Pharmacogenomics, 2013, Volume: 14, Issue:12

    Topics: Aged; Antineoplastic Agents, Alkylating; Chemical and Drug Induced Liver Injury; Dioxoles; Genotype; Humans; Liver; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Polymorphism, Genetic; Sarcoma; Tetrahydroisoquinolines; Trabectedin

2013
Fatal hepatic and renal toxicity as a complication of trabectedin therapy for radiation-induced sarcoma.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2010, Volume: 16, Issue:4

    Topics: Acute Kidney Injury; Aged; Antineoplastic Agents, Alkylating; Chemical and Drug Induced Liver Injury; Dioxoles; Fatal Outcome; Humans; Liver Failure, Acute; Male; Neoplasms, Radiation-Induced; Sarcoma; Skull Base Neoplasms; Tetrahydroisoquinolines; Trabectedin

2010
Hepatobiliary damage and changes in hepatic gene expression caused by the antitumor drug ecteinascidin-743 (ET-743) in the female rat.
    Cancer research, 2002, Aug-01, Volume: 62, Issue:15

    Topics: Animals; Antineoplastic Agents, Alkylating; Bile Duct Diseases; Bilirubin; Cell Division; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dioxoles; Female; Gene Expression; Isoquinolines; Liver; Liver Diseases; Rats; Rats, Wistar; Tetrahydroisoquinolines; Trabectedin

2002
Complete protection by high-dose dexamethasone against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the rat.
    Cancer research, 2003, Sep-15, Volume: 63, Issue:18

    Topics: Animals; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Dexamethasone; Dioxoles; Down-Regulation; Drug Interactions; Female; Gene Expression; Isoquinolines; Liver; Liver Diseases; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Oligonucleotide Array Sequence Analysis; Oxidoreductases, N-Demethylating; Rats; Rats, Inbred F344; Rats, Wistar; Tetrahydroisoquinolines; Trabectedin

2003
Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro.
    Cancer chemotherapy and pharmacology, 2004, Volume: 53, Issue:4

    Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Antineoplastic Agents, Alkylating; Aspartate Aminotransferases; beta-Naphthoflavone; Cell Survival; Chemical and Drug Induced Liver Injury; Dexamethasone; Dioxoles; Female; Hepatocytes; Inactivation, Metabolic; Isoquinolines; Liver; Phenobarbital; Rats; Rats, Wistar; Tetrahydroisoquinolines; Trabectedin

2004
Steroid premedication markedly reduces liver and bone marrow toxicity of trabectedin in advanced sarcoma.
    European journal of cancer (Oxford, England : 1990), 2006, Volume: 42, Issue:10

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Dioxoles; Disease-Free Survival; Female; Humans; Liver Diseases; Male; Middle Aged; Premedication; Sarcoma; Steroids; Tetrahydroisoquinolines; Trabectedin

2006
Semimechanistic pharmacokinetic/pharmacodynamic model for hepatoprotective effect of dexamethasone on transient transaminitis after trabectedin (ET-743) treatment.
    Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Algorithms; Analysis of Variance; Anti-Inflammatory Agents; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Computer Simulation; Data Interpretation, Statistical; Dexamethasone; Dioxoles; Drug Tolerance; Female; Finite Element Analysis; Humans; Intercalating Agents; Male; Middle Aged; Models, Statistical; Software; Tetrahydroisoquinolines; Trabectedin; Transaminases

2008
Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity.
    Toxicology and applied pharmacology, 2008, Apr-01, Volume: 228, Issue:1

    Topics: Animals; Animals, Genetically Modified; Anti-Inflammatory Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Bile; Blotting, Western; Buthionine Sulfoximine; Cell Separation; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dexamethasone; Dioxoles; Enzyme Inhibitors; Hepatocytes; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Rats; Rats, Wistar; Tetrahydroisoquinolines; Trabectedin

2008