econazole has been researched along with Leukemia in 4 studies
Econazole: An imidazole derivative that is commonly used as a topical antifungal agent.
econazole : A racemate composed of equimolar amounts of (R)- and (S)-econazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections.
1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 4-chlorobenzyl group.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate apoptosis of mouse leukemia cell (WEHI-3) induced by econazole and its mechanism, apoptosis induced by econazole was examined by flow cytometry, while free calcium ([Ca(2+)]i) was determined by Fura-2 fluorescein load technique." | 7.73 | [Experimental study on apoptosis in leukemia cells induced by econazole]. ( Liu, F; Wu, YH; Xiao, J; Zhang, M; Zou, P, 2005) |
| "To investigate apoptosis of mouse leukemia cell (WEHI-3) induced by econazole and its mechanism, apoptosis induced by econazole was examined by flow cytometry, while free calcium ([Ca(2+)]i) was determined by Fura-2 fluorescein load technique." | 3.73 | [Experimental study on apoptosis in leukemia cells induced by econazole]. ( Liu, F; Wu, YH; Xiao, J; Zhang, M; Zou, P, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Y | 2 |
| Berger, SA | 2 |
| Liu, F | 1 |
| Zou, P | 1 |
| Zhang, M | 1 |
| Wu, YH | 1 |
| Xiao, J | 1 |
| Soboloff, J | 1 |
| Zhu, Z | 1 |
| Alonso-Torre, SR | 1 |
| Alvarez, J | 1 |
| Montero, M | 1 |
| Sanchez, A | 1 |
| García-Sancho, J | 1 |
4 other studies available for econazole and Leukemia
| Article | Year |
|---|---|
Increased calcium influx and ribosomal content correlate with resistance to endoplasmic reticulum stress-induced cell death in mutant leukemia cell lines.
Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Area Under Cu | 2004 |
[Experimental study on apoptosis in leukemia cells induced by econazole].
Topics: Animals; Apoptosis; Blotting, Western; Calcium; Caspase 12; Caspase 7; Cell Line, Tumor; Dose-Respon | 2005 |
Inhibition of Ca2+ influx is required for mitochondrial reactive oxygen species-induced endoplasmic reticulum Ca2+ depletion and cell death in leukemia cells.
Topics: Adenine Nucleotides; Antimycin A; Antioxidants; Atractyloside; Calcium; Caspases; Cell Death; Cell L | 2006 |
Control of Ca2+ entry into HL60 and U937 human leukaemia cells by the filling state of the intracellular Ca2+ stores.
Topics: Antifungal Agents; Biological Transport; Calcium; Cell Differentiation; Cytochrome P-450 Enzyme Inhi | 1993 |