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econazole and Leukemia

econazole has been researched along with Leukemia in 4 studies

Econazole: An imidazole derivative that is commonly used as a topical antifungal agent.
econazole : A racemate composed of equimolar amounts of (R)- and (S)-econazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections.
1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 4-chlorobenzyl group.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"To investigate apoptosis of mouse leukemia cell (WEHI-3) induced by econazole and its mechanism, apoptosis induced by econazole was examined by flow cytometry, while free calcium ([Ca(2+)]i) was determined by Fura-2 fluorescein load technique."7.73[Experimental study on apoptosis in leukemia cells induced by econazole]. ( Liu, F; Wu, YH; Xiao, J; Zhang, M; Zou, P, 2005)
"To investigate apoptosis of mouse leukemia cell (WEHI-3) induced by econazole and its mechanism, apoptosis induced by econazole was examined by flow cytometry, while free calcium ([Ca(2+)]i) was determined by Fura-2 fluorescein load technique."3.73[Experimental study on apoptosis in leukemia cells induced by econazole]. ( Liu, F; Wu, YH; Xiao, J; Zhang, M; Zou, P, 2005)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's3 (75.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, Y2
Berger, SA2
Liu, F1
Zou, P1
Zhang, M1
Wu, YH1
Xiao, J1
Soboloff, J1
Zhu, Z1
Alonso-Torre, SR1
Alvarez, J1
Montero, M1
Sanchez, A1
GarcĂ­a-Sancho, J1

Other Studies

4 other studies available for econazole and Leukemia

ArticleYear
Increased calcium influx and ribosomal content correlate with resistance to endoplasmic reticulum stress-induced cell death in mutant leukemia cell lines.
    The Journal of biological chemistry, 2004, Feb-20, Volume: 279, Issue:8

    Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Area Under Cu

2004
[Experimental study on apoptosis in leukemia cells induced by econazole].
    Zhongguo shi yan xue ye xue za zhi, 2005, Volume: 13, Issue:3

    Topics: Animals; Apoptosis; Blotting, Western; Calcium; Caspase 12; Caspase 7; Cell Line, Tumor; Dose-Respon

2005
Inhibition of Ca2+ influx is required for mitochondrial reactive oxygen species-induced endoplasmic reticulum Ca2+ depletion and cell death in leukemia cells.
    Molecular pharmacology, 2006, Volume: 70, Issue:4

    Topics: Adenine Nucleotides; Antimycin A; Antioxidants; Atractyloside; Calcium; Caspases; Cell Death; Cell L

2006
Control of Ca2+ entry into HL60 and U937 human leukaemia cells by the filling state of the intracellular Ca2+ stores.
    The Biochemical journal, 1993, Feb-01, Volume: 289 ( Pt 3)

    Topics: Antifungal Agents; Biological Transport; Calcium; Cell Differentiation; Cytochrome P-450 Enzyme Inhi

1993