echinomycin and Ovarian-Neoplasms

Twenty-two patients with recurrent carcinoma of the ovary progressive after initial chemotherapy (21 with cisplatin-based treatment) were entered on a phase II trial utilizing Echinomycin at a dosage of 1,500 micrograms/m2 every 4 weeks. There were two complete responders and no partial responders (9% response, 95% confidence intervals for complete and partial responses of 1-29%). Major toxicity was modest and consisted mainly of nausea and vomiting. Echinomycin displays minimal activity as salvage therapy in women with advanced ovarian cancer at this dose and schedule.

Topics: Adult; Aged; Carcinoma; Drug Evaluation; Echinomycin; Female; Humans; Infusions, Intravenous; Middle Aged; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Ovarian Neoplasms; Quinoxalines; Remission Induction