echinomycin and Lymphoma

echinomycin has been researched along with Lymphoma* in 1 studies

Other Studies

1 other study(ies) available for echinomycin and Lymphoma

ArticleYear
Hypoxia inducible factor 1α expression and effects of its inhibitors in canine lymphoma.
    The Journal of veterinary medical science, 2015, Volume: 77, Issue:11

    Hypoxic conditions in various cancers are believed to relate with their malignancy, and hypoxia inducible factor-1α (HIF-1α) has been shown to be a major regulator of the response to low oxygen. In this study, we examined HIF-1α expression in canine lymphoma using cell lines and clinical samples and found that these cells expressed HIF-1α. Moreover, the HIF-1α inhibitors, echinomycin, YC-1 and 2-methoxyestradiol, suppressed the proliferation of canine lymphoma cell lines. In a xenograft model using NOD/scid mice, echinomycin treatment resulted in a dose-dependent regression of the tumor. Our results suggest that HIF-1α contributes to the proliferation and/or survival of canine lymphoma cells. Therefore, HIF-1α inhibitors may be potential agents to treat canine lymphoma.

    Topics: Animals; Cell Line, Tumor; Dog Diseases; Dogs; Echinomycin; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lymphoma; Mice; Neoplasms, Experimental

2015