echinomycin has been researched along with Leukemia-P388* in 2 studies
2 other study(ies) available for echinomycin and Leukemia-P388
| Article | Year |
|---|---|
A new antitumor agent: methyl sulfonium perchlorate of echinomycin.
Newly modified-echinomycin such as S-methylated sulfonium perchlorate of echinomycin (1), monosulfoxide (2), disulfoxid (3) and sulfone (4) have been prepared and evaluated for in vitro biological activities of cytotoxicity against P388, B16 and SNU-16 as well as in vivo antitumor activity against murine leukemia P388 and melanoma B16. Topics: Animals; Antibiotics, Antineoplastic; Cell Survival; Drug Design; Echinomycin; Leukemia P388; Melanoma, Experimental; Mice; Molecular Structure; Structure-Activity Relationship; Sulfones; Sulfoxides; Tumor Cells, Cultured | 1998 |
Quinaldopeptin, a novel antibiotic of the quinomycin family.
Quinaldopeptin, a new type of quinomycin antibiotic, was isolated from the culture of Streptoverticillium album strain Q132-6. The antibiotic exhibited strong in vitro antimicrobial and cytotoxic activity and significantly prolonged the survival time of mice inoculated with a murine tumor. Quinaldopeptin is a symmetric cyclic peptide linked only by peptide bonds and differs from known antibiotics of the quinomycin family by the lack of ester linkage. Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Bacteria; Echinomycin; Fungi; Humans; Leukemia P388; Leukemia, Experimental; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Quinoxalines; Spectrum Analysis; Streptomycetaceae; Tumor Cells, Cultured | 1990 |