echinochrome-a and Pulmonary-Fibrosis

We studied the protective effect of antioxidant echinochrome A on bleomycin-induced pulmonary fibrosis in rats at the early stages of postnatal ontogeny. Administration of echinochrome A was shown to reduce the severity of bleomycin-induced oxidative stress in the lungs, prevented the development of hypertrophy of interalveolar connective tissue and peribronchial lymphoid infiltration, and normalized the ratio of volume densities of interalveolar septa and alveolar lumen.

Topics: Animals; Antioxidants; Bleomycin; Lung; Naphthoquinones; Pulmonary Fibrosis; Rats