echinochrome-a and Diabetes-Mellitus

Diabetes mellitus is the main reason of morbidity and mortality worldwide. In recent years great attention has been paid to bioactivity of natural products due to their potential pharmacological utilization. Echinochrome is a natural compound isolated from sea urchins and possesses many biological effects. The hypoglycemic activity of echinochrome reported in many recent experiments.. In our study, we tried to collect all the possible hypoglycemic mechanism of echinochrome.. The hypoglycemic effect of echinochrome involving four main pathways; regeneration of pancreas, decrease insulin resistant, increase insulin production and improve glucose homeostasis.

Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Cholinesterase Inhibitors; Diabetes Mellitus; Glucosephosphate Dehydrogenase; Heme Oxygenase-1; Hexokinase; Homeostasis; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Naphthoquinones; Pancreas; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphatidylinositol 3-Kinase; Regeneration; Signal Transduction

Topics: Animals; Antioxidants; Diabetes Mellitus; Diabetic Nephropathies; Kidney; Mice; Mice, Inbred Strains; Mitochondria; NF-E2-Related Factor 2; Oxidative Stress