echinocandin-b and Body-Weight

echinocandin-b has been researched along with Body-Weight* in 1 studies

Other Studies

1 other study(ies) available for echinocandin-b and Body-Weight

ArticleYear
The synthesis and activity evaluation of N-acylated analogs of echinocandin B with improved solubility and lower toxicity.
    Journal of peptide science : an official publication of the European Peptide Society, 2020, Volume: 26, Issue:11

    Presently, echinocandins have been recommended as the first-line drugs for the treatment of invasive candidiasis. However, low oral bioavailability and solubility limit their application. To improve this situation, this study chose amino acid and fatty acid as raw materials to modify the nucleus of echinocandin B. Six N-acylated analogs were screened from the derivatives that possessed potent antifungal activity and good water solubility. Based on antifungal susceptibility and hemolytic toxicity, compound 5 as the candidate had good antifungal activity and no hemolytic effect. Moreover, compared with anidulafungin, compound 5 showed a comparable fungicidal effect, much higher solubility, and lower toxicity. In conclusion, compound 5 has the potential for further research and development on account of reserved antifungal activity, high solubility, and low toxicity.

    Topics: Acylation; Animals; Antifungal Agents; Body Weight; Candida albicans; Echinocandins; Fungal Proteins; Macrophages; Male; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Molecular Structure; RAW 264.7 Cells; Solubility

2020