ebselen has been researched along with Stroke in 8 studies
ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study indicates that ebselen may be neuroprotective when administered shortly after an embolic stroke, but the time- and dose-response analyses suggest that it has a narrow therapeutic window." | 7.72 | Ebselen, a seleno-organic antioxidant, is neuroprotective after embolic strokes in rabbits: synergism with low-dose tissue plasminogen activator. ( Lapchak, PA; Zivin, JA, 2003) |
| " We sought to investigate whether long-term administration of seleno-glutathione peroxidase mimic ebselen (PZ51) would have a protective effect on cortical neurons in SHRsp, and, if so, the possible mechanisms of this effect." | 5.33 | Protective effect of antioxidant ebselen (PZ51) on the cerebral cortex of stroke-prone spontaneously hypertensive rats. ( Liu, LS; Sui, H; Wang, PH; Wang, W, 2005) |
| "Radical scavenger compounds (such as Ebselen and Edaravone) are under clinical investigation as a therapeutic approach against stroke." | 4.91 | Pathophysiology and Treatments of Oxidative Injury in Ischemic Stroke: Focus on the Phagocytic NADPH Oxidase 2. ( Braunersreuther, V; Carbone, F; Mach, F; Montecucco, F; Teixeira, PC; Vuilleumier, N, 2015) |
| " Four compounds with free radical scavenging activity (tirilazad, ebselen, edaravone) or free radical trapping properties (NXY-059) have been examined in experimental models of stroke and evaluated clinically as neuroprotective agents." | 4.82 | Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers. ( Ashwood, T; Green, AR, 2005) |
| "This study indicates that ebselen may be neuroprotective when administered shortly after an embolic stroke, but the time- and dose-response analyses suggest that it has a narrow therapeutic window." | 3.72 | Ebselen, a seleno-organic antioxidant, is neuroprotective after embolic strokes in rabbits: synergism with low-dose tissue plasminogen activator. ( Lapchak, PA; Zivin, JA, 2003) |
| "Ebselen is a synthetic organoselenium radical scavenger compound that possesses glutathione peroxidase-like activity and its own unique bioactivity by reacting with thiols, hydroperoxides and peroxynitrites." | 2.66 | Mechanisms of ebselen as a therapeutic and its pharmacology applications. ( Dong, C; Wang, J; Wang, P; Yuan, C; Zhao, Y; Zhou, J; Zou, L, 2020) |
| " We sought to investigate whether long-term administration of seleno-glutathione peroxidase mimic ebselen (PZ51) would have a protective effect on cortical neurons in SHRsp, and, if so, the possible mechanisms of this effect." | 1.33 | Protective effect of antioxidant ebselen (PZ51) on the cerebral cortex of stroke-prone spontaneously hypertensive rats. ( Liu, LS; Sui, H; Wang, PH; Wang, W, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, J | 1 |
| Wang, P | 1 |
| Dong, C | 1 |
| Zhao, Y | 1 |
| Zhou, J | 1 |
| Yuan, C | 1 |
| Zou, L | 1 |
| Carbone, F | 1 |
| Teixeira, PC | 1 |
| Braunersreuther, V | 1 |
| Mach, F | 1 |
| Vuilleumier, N | 1 |
| Montecucco, F | 1 |
| Minnerup, J | 1 |
| Sutherland, BA | 1 |
| Buchan, AM | 1 |
| Kleinschnitz, C | 1 |
| Lapchak, PA | 1 |
| Zivin, JA | 1 |
| Green, AR | 1 |
| Ashwood, T | 1 |
| Sui, H | 1 |
| Wang, W | 1 |
| Wang, PH | 1 |
| Liu, LS | 1 |
| Yamagata, K | 1 |
| Ichinose, S | 1 |
| Miyashita, A | 1 |
| Tagami, M | 1 |
4 reviews available for ebselen and Stroke
| Article | Year |
|---|---|
Mechanisms of ebselen as a therapeutic and its pharmacology applications.
Topics: Animals; Azoles; Bipolar Disorder; Cardiovascular Diseases; Hearing Loss, Sensorineural; Humans; Imm | 2020 |
Pathophysiology and Treatments of Oxidative Injury in Ischemic Stroke: Focus on the Phagocytic NADPH Oxidase 2.
Topics: Animals; Antioxidants; Antipyrine; Azoles; Brain; Edaravone; Humans; Isoindoles; Membrane Glycoprote | 2015 |
Neuroprotection for stroke: current status and future perspectives.
Topics: Animals; Antioxidants; Azoles; Benzenesulfonates; Clinical Trials as Topic; Disease Models, Animal; | 2012 |
Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers.
Topics: Animals; Antioxidants; Antipyrine; Azoles; Benzenesulfonates; Brain Ischemia; Edaravone; Free Radica | 2005 |
4 other studies available for ebselen and Stroke
| Article | Year |
|---|---|
Ebselen could be used as anti-inflammatory Nox inhibitor.
Topics: Anti-Inflammatory Agents; Azoles; Catalytic Domain; Hearing Loss; Humans; Isoindoles; NADPH Oxidases | 2012 |
Ebselen, a seleno-organic antioxidant, is neuroprotective after embolic strokes in rabbits: synergism with low-dose tissue plasminogen activator.
Topics: Animals; Antioxidants; Azoles; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, | 2003 |
Protective effect of antioxidant ebselen (PZ51) on the cerebral cortex of stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Azoles; Blood Pressure; Blotting, Western; Body Weight; Cerebral Cortex; Hype | 2005 |
Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat.
Topics: Animals; Antioxidants; Azoles; bcl-2-Associated X Protein; Cell Death; Cells, Cultured; DNA, Complem | 2008 |