ebselen has been researched along with Seizures in 4 studies
ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lithium, commonly used to treat bipolar disorder, potentiates the ability of the muscarinic agonist pilocarpine to induce seizures in rodents." | 3.96 | Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity. ( Agam, G; Batra, AS; Belmaker, RH; Blackburn, V; Churchill, GC; Sade, Y; Saiardi, A; Serres, F; Sharp, T; Singh, N; Toker, L; Vasudevan, SR, 2020) |
| "The attenuation in the drop of NMDA seizure threshold (percentage of reversal) was 58 and 20 % upon acute intraperitoneal administrations of magnesium chloride hexahydrate (28 mg magnesium/kg) and the antioxidant ebselen (20 mg/kg), respectively." | 1.35 | Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations. ( Agnani, G; Bac, P; Delplanque, B; Durlach, J; German-Fattal, M; Maurois, P; Pages, N; Poupaert, J; Vamecq, J, 2009) |
| "ALA-induced convulsions were not prevented by ascorbic acid, but were partially prevented by DMSO and completely prevented by ebselen." | 1.32 | Dimethyl sulfoxide and ebselen prevent convulsions induced by 5-aminolevulinic acid. ( Agostini, AN; Augusti, PR; Emanuelli, T; Mello, CF; Morimoto, A; Prauchner, CA; Unfer, TC; Zeni, G, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, N | 1 |
| Serres, F | 1 |
| Toker, L | 1 |
| Sade, Y | 1 |
| Blackburn, V | 1 |
| Batra, AS | 1 |
| Saiardi, A | 1 |
| Agam, G | 1 |
| Belmaker, RH | 1 |
| Sharp, T | 1 |
| Vasudevan, SR | 1 |
| Churchill, GC | 1 |
| Maurois, P | 1 |
| Pages, N | 1 |
| Bac, P | 1 |
| German-Fattal, M | 1 |
| Agnani, G | 1 |
| Delplanque, B | 1 |
| Durlach, J | 1 |
| Poupaert, J | 1 |
| Vamecq, J | 1 |
| Prauchner, CA | 1 |
| Agostini, AN | 1 |
| Morimoto, A | 1 |
| Augusti, PR | 1 |
| Unfer, TC | 1 |
| Zeni, G | 1 |
| Mello, CF | 1 |
| Emanuelli, T | 1 |
| Baran, H | 1 |
| Vass, K | 1 |
| Lassmann, H | 1 |
| Hornykiewicz, O | 1 |
4 other studies available for ebselen and Seizures
| Article | Year |
|---|---|
Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity.
Topics: Animals; Anticonvulsants; Azoles; Brain; Calcium Signaling; CHO Cells; Cricetulus; Disease Models, A | 2020 |
Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations.
Topics: Acoustic Stimulation; Animals; Antioxidants; Azoles; Dose-Response Relationship, Drug; Isoindoles; M | 2009 |
Dimethyl sulfoxide and ebselen prevent convulsions induced by 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Azoles; Dimethyl Sulfoxide; Isoindoles; Male; Organoselenium Compounds | 2004 |
The cyclooxygenase and lipoxygenase inhibitor BW755C protects rats against kainic acid-induced seizures and neurotoxicity.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non | 1994 |