Page last updated: 2024-10-26

ebselen and Seizures

ebselen has been researched along with Seizures in 4 studies

ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"Lithium, commonly used to treat bipolar disorder, potentiates the ability of the muscarinic agonist pilocarpine to induce seizures in rodents."3.96Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity. ( Agam, G; Batra, AS; Belmaker, RH; Blackburn, V; Churchill, GC; Sade, Y; Saiardi, A; Serres, F; Sharp, T; Singh, N; Toker, L; Vasudevan, SR, 2020)
"The attenuation in the drop of NMDA seizure threshold (percentage of reversal) was 58 and 20 % upon acute intraperitoneal administrations of magnesium chloride hexahydrate (28 mg magnesium/kg) and the antioxidant ebselen (20 mg/kg), respectively."1.35Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations. ( Agnani, G; Bac, P; Delplanque, B; Durlach, J; German-Fattal, M; Maurois, P; Pages, N; Poupaert, J; Vamecq, J, 2009)
"ALA-induced convulsions were not prevented by ascorbic acid, but were partially prevented by DMSO and completely prevented by ebselen."1.32Dimethyl sulfoxide and ebselen prevent convulsions induced by 5-aminolevulinic acid. ( Agostini, AN; Augusti, PR; Emanuelli, T; Mello, CF; Morimoto, A; Prauchner, CA; Unfer, TC; Zeni, G, 2004)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Singh, N1
Serres, F1
Toker, L1
Sade, Y1
Blackburn, V1
Batra, AS1
Saiardi, A1
Agam, G1
Belmaker, RH1
Sharp, T1
Vasudevan, SR1
Churchill, GC1
Maurois, P1
Pages, N1
Bac, P1
German-Fattal, M1
Agnani, G1
Delplanque, B1
Durlach, J1
Poupaert, J1
Vamecq, J1
Prauchner, CA1
Agostini, AN1
Morimoto, A1
Augusti, PR1
Unfer, TC1
Zeni, G1
Mello, CF1
Emanuelli, T1
Baran, H1
Vass, K1
Lassmann, H1
Hornykiewicz, O1

Other Studies

4 other studies available for ebselen and Seizures

ArticleYear
Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity.
    European journal of pharmacology, 2020, Sep-15, Volume: 883

    Topics: Animals; Anticonvulsants; Azoles; Brain; Calcium Signaling; CHO Cells; Cricetulus; Disease Models, A

2020
Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations.
    The British journal of nutrition, 2009, Volume: 101, Issue:3

    Topics: Acoustic Stimulation; Animals; Antioxidants; Azoles; Dose-Response Relationship, Drug; Isoindoles; M

2009
Dimethyl sulfoxide and ebselen prevent convulsions induced by 5-aminolevulinic acid.
    Neurochemical research, 2004, Volume: 29, Issue:10

    Topics: Aminolevulinic Acid; Animals; Azoles; Dimethyl Sulfoxide; Isoindoles; Male; Organoselenium Compounds

2004
The cyclooxygenase and lipoxygenase inhibitor BW755C protects rats against kainic acid-induced seizures and neurotoxicity.
    Brain research, 1994, May-23, Volume: 646, Issue:2

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non

1994