ebselen has been researched along with Reperfusion Injury in 18 studies
ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We compared the influence of a dietary surplus of Se and pretreatment with ebselen, a mimic of the selenoenzyme glutathione peroxidase, on IRI-induced tissue damage and inflammation." | 7.83 | Selenium Pretreatment for Mitigation of Ischemia/Reperfusion Injury in Cardiovascular Surgery: Influence on Acute Organ Damage and Inflammatory Response. ( Akhyari, P; Bilgic, E; Boeken, U; Döhrn, L; Engels, M; Kellermann, K; Lichtenberg, A; Pinto, A; Steinbrenner, H; Wollschläger, L, 2016) |
| " Therefore, we aimed to investigate the roles of N-acetylcysteine (NAC), a well-known powerful antioxidant, and ebselen (E), a scavenger of peroxynitrite, on renal injury induced by renal ischemia/reperfusion injury (IRI) of rat kidney." | 7.77 | Beneficial effects of N-acetylcysteine and ebselen on renal ischemia/reperfusion injury. ( Akgul, OE; Cakir, E; Cayci, T; Kizilgun, M; Kunak, ZI; Kurt, YG; Macit, E; Ozcan, A; Ozkan, E; Oztas, Y; Poyrazoglu, Y; Taslipinar, MY; Turker, T; Yaman, H; Yaren, H, 2011) |
| "The present study was designed to examine the in vivo effect of ebselen on reperfusion injury to the liver." | 7.69 | Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemia-reperfusion injury. ( Nakamura, M; Ota, K; Ozaki, M; Teraoka, S, 1997) |
| "Ebselen is an organic selenide that attenuates I/R injury in various organs." | 5.72 | Ebselen ameliorates renal ischemia-reperfusion injury via enhancing autophagy in rats. ( Chen, W; Pei, J; Shi, H; Song, S; Wu, Y; Xu, S; Xu, Y, 2022) |
| "Ebselen is an organoselenium compound which has strong antioxidant and anti-inflammatory effects." | 5.42 | Different dose-dependent effects of ebselen in sciatic nerve ischemia-reperfusion injury in rats. ( Akcer, S; Genc, O; Kocak, A; Kocak, C; Kocak, FE; Kucuk, A; Metineren, H; Ozyigit, F; Tosun, M, 2015) |
| "Ebselen has neuron-protective effects due to its antioxidant properties as shown by the decrease in MDA overproduction, increase in SOD activity and the histological improvement after administration of Ebselen to I/R in brain tissue." | 5.40 | Effects of ebselen on ischemia/reperfusion injury in rat brain. ( Altaş, M; Aras, M; Karcıoğlu, M; Meydan, S; Nacar, E; Serarslan, Y; Ulutaş, KT, 2014) |
| "Pretreatment with ebselen prevented the death by 56% and attenuated neurological damage (abnormal eyelid drooping, hair bristling, muscle tone, flexor reflex, posture, and walking patterns)." | 5.40 | Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils. ( Daily, JW; Kang, S; Kim, DS; Moon, NR; Park, S; Shin, BK, 2014) |
| "Both erdosteine and ebselen were able to attenuate I/R injury of the intestine via inhibition of lipid peroxidation and protein oxidation, maintenance of antioxidant, and free radical scavenger properties." | 5.35 | Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury. ( Atabek, C; Caliskan, B; Ersoz, N; Guven, A; Kesik, V; Oter, S; Oztas, E; Tunc, T; Uysal, B, 2009) |
| " We compared the influence of a dietary surplus of Se and pretreatment with ebselen, a mimic of the selenoenzyme glutathione peroxidase, on IRI-induced tissue damage and inflammation." | 3.83 | Selenium Pretreatment for Mitigation of Ischemia/Reperfusion Injury in Cardiovascular Surgery: Influence on Acute Organ Damage and Inflammatory Response. ( Akhyari, P; Bilgic, E; Boeken, U; Döhrn, L; Engels, M; Kellermann, K; Lichtenberg, A; Pinto, A; Steinbrenner, H; Wollschläger, L, 2016) |
| "Ebselen is used as a drug in clinical trials against stroke, reperfusion injury with anti-atherosclerotic and renoprotective effects." | 3.80 | Protective effect of ebselen on experimental testicular torsion and detorsion injury. ( Davarci, I; Davarci, M; Motor, S; Nacar, A; Rifaioglu, MM; Sefil, F; Tuzcu, K, 2014) |
| " Therefore, we aimed to investigate the roles of N-acetylcysteine (NAC), a well-known powerful antioxidant, and ebselen (E), a scavenger of peroxynitrite, on renal injury induced by renal ischemia/reperfusion injury (IRI) of rat kidney." | 3.77 | Beneficial effects of N-acetylcysteine and ebselen on renal ischemia/reperfusion injury. ( Akgul, OE; Cakir, E; Cayci, T; Kizilgun, M; Kunak, ZI; Kurt, YG; Macit, E; Ozcan, A; Ozkan, E; Oztas, Y; Poyrazoglu, Y; Taslipinar, MY; Turker, T; Yaman, H; Yaren, H, 2011) |
| "The present study was designed to examine the in vivo effect of ebselen on reperfusion injury to the liver." | 3.69 | Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemia-reperfusion injury. ( Nakamura, M; Ota, K; Ozaki, M; Teraoka, S, 1997) |
| "Ebselen is an organic selenide that attenuates I/R injury in various organs." | 1.72 | Ebselen ameliorates renal ischemia-reperfusion injury via enhancing autophagy in rats. ( Chen, W; Pei, J; Shi, H; Song, S; Wu, Y; Xu, S; Xu, Y, 2022) |
| "Ebselen is an organoselenium compound which has strong antioxidant and anti-inflammatory effects." | 1.42 | Different dose-dependent effects of ebselen in sciatic nerve ischemia-reperfusion injury in rats. ( Akcer, S; Genc, O; Kocak, A; Kocak, C; Kocak, FE; Kucuk, A; Metineren, H; Ozyigit, F; Tosun, M, 2015) |
| "Ebselen has neuron-protective effects due to its antioxidant properties as shown by the decrease in MDA overproduction, increase in SOD activity and the histological improvement after administration of Ebselen to I/R in brain tissue." | 1.40 | Effects of ebselen on ischemia/reperfusion injury in rat brain. ( Altaş, M; Aras, M; Karcıoğlu, M; Meydan, S; Nacar, E; Serarslan, Y; Ulutaş, KT, 2014) |
| "Pretreatment with ebselen prevented the death by 56% and attenuated neurological damage (abnormal eyelid drooping, hair bristling, muscle tone, flexor reflex, posture, and walking patterns)." | 1.40 | Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils. ( Daily, JW; Kang, S; Kim, DS; Moon, NR; Park, S; Shin, BK, 2014) |
| "Both erdosteine and ebselen were able to attenuate I/R injury of the intestine via inhibition of lipid peroxidation and protein oxidation, maintenance of antioxidant, and free radical scavenger properties." | 1.35 | Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury. ( Atabek, C; Caliskan, B; Ersoz, N; Guven, A; Kesik, V; Oter, S; Oztas, E; Tunc, T; Uysal, B, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 7 (38.89) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Anzini, M | 1 |
| Chelini, A | 1 |
| Mancini, A | 1 |
| Cappelli, A | 1 |
| Frosini, M | 1 |
| Ricci, L | 1 |
| Valoti, M | 1 |
| Magistretti, J | 1 |
| Castelli, L | 1 |
| Giordani, A | 1 |
| Makovec, F | 1 |
| Vomero, S | 1 |
| Wu, Y | 2 |
| Shi, H | 2 |
| Xu, Y | 2 |
| Pei, J | 1 |
| Song, S | 1 |
| Chen, W | 1 |
| Xu, S | 2 |
| Wen, R | 1 |
| Gong, M | 1 |
| Hong, G | 1 |
| Aras, M | 1 |
| Altaş, M | 1 |
| Meydan, S | 1 |
| Nacar, E | 1 |
| Karcıoğlu, M | 1 |
| Ulutaş, KT | 1 |
| Serarslan, Y | 1 |
| Park, S | 1 |
| Kang, S | 1 |
| Kim, DS | 1 |
| Shin, BK | 1 |
| Moon, NR | 1 |
| Daily, JW | 1 |
| Rifaioglu, MM | 1 |
| Motor, S | 1 |
| Davarci, I | 1 |
| Tuzcu, K | 1 |
| Sefil, F | 1 |
| Davarci, M | 1 |
| Nacar, A | 1 |
| Ozyigit, F | 1 |
| Kucuk, A | 1 |
| Akcer, S | 1 |
| Tosun, M | 1 |
| Kocak, FE | 1 |
| Kocak, C | 1 |
| Kocak, A | 1 |
| Metineren, H | 1 |
| Genc, O | 1 |
| Steinbrenner, H | 1 |
| Bilgic, E | 1 |
| Pinto, A | 1 |
| Engels, M | 1 |
| Wollschläger, L | 1 |
| Döhrn, L | 1 |
| Kellermann, K | 1 |
| Boeken, U | 1 |
| Akhyari, P | 1 |
| Lichtenberg, A | 1 |
| Wong, CH | 1 |
| Bozinovski, S | 1 |
| Hertzog, PJ | 1 |
| Hickey, MJ | 1 |
| Crack, PJ | 1 |
| Guven, A | 2 |
| Tunc, T | 2 |
| Topal, T | 1 |
| Kul, M | 1 |
| Korkmaz, A | 1 |
| Gundogdu, G | 1 |
| Onguru, O | 1 |
| Ozturk, H | 1 |
| Uysal, B | 1 |
| Atabek, C | 1 |
| Kesik, V | 1 |
| Caliskan, B | 1 |
| Oztas, E | 1 |
| Ersoz, N | 1 |
| Oter, S | 1 |
| Seo, JY | 1 |
| Lee, CH | 1 |
| Cho, JH | 1 |
| Choi, JH | 1 |
| Yoo, KY | 1 |
| Kim, DW | 1 |
| Park, OK | 1 |
| Li, H | 1 |
| Choi, SY | 1 |
| Hwang, IK | 1 |
| Won, MH | 1 |
| Kizilgun, M | 1 |
| Poyrazoglu, Y | 1 |
| Oztas, Y | 1 |
| Yaman, H | 1 |
| Cakir, E | 1 |
| Cayci, T | 1 |
| Akgul, OE | 1 |
| Kurt, YG | 1 |
| Yaren, H | 1 |
| Kunak, ZI | 1 |
| Macit, E | 1 |
| Ozkan, E | 1 |
| Taslipinar, MY | 1 |
| Turker, T | 1 |
| Ozcan, A | 1 |
| Yokozawa, T | 1 |
| Rhyu, DY | 1 |
| Cho, EJ | 1 |
| Yamagata, K | 1 |
| Ichinose, S | 1 |
| Miyashita, A | 1 |
| Tagami, M | 1 |
| Ozaki, M | 1 |
| Nakamura, M | 1 |
| Teraoka, S | 1 |
| Ota, K | 1 |
| Noiri, E | 1 |
| Nakao, A | 1 |
| Uchida, K | 1 |
| Tsukahara, H | 1 |
| Ohno, M | 1 |
| Fujita, T | 1 |
| Brodsky, S | 1 |
| Goligorsky, MS | 1 |
| Ueda, S | 1 |
| Yoshikawa, T | 1 |
| Takahashi, S | 1 |
| Naito, Y | 1 |
| Oyamada, H | 1 |
| Takemura, T | 1 |
| Morita, Y | 1 |
| Tanigawa, T | 1 |
| Sugino, S | 1 |
| Kondo, M | 1 |
18 other studies available for ebselen and Reperfusion Injury
| Article | Year |
|---|---|
Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases.
Topics: Amidines; Animals; Antioxidants; Benzothiazoles; Brain Diseases; Calcium; Guanidines; Ion Transport; | 2010 |
Ebselen ameliorates renal ischemia-reperfusion injury via enhancing autophagy in rats.
Topics: Animals; Autophagy; Humans; Isoindoles; NF-E2-Related Factor 2; Organoselenium Compounds; Oxidative | 2022 |
Selenoprotein Gene mRNA Expression Evaluation During Renal Ischemia-Reperfusion Injury in Rats and Ebselen Intervention Effects.
Topics: Animals; Kidney; Mammals; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Selenium; | 2023 |
Effects of ebselen on ischemia/reperfusion injury in rat brain.
Topics: Animals; Azoles; Brain; Brain Ischemia; Catalase; Disease Models, Animal; Glutathione Peroxidase; Is | 2014 |
Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Brain Ischemia; Cell Survival; Cytokines; | 2014 |
Protective effect of ebselen on experimental testicular torsion and detorsion injury.
Topics: Animals; Antioxidants; Azoles; Catalase; Isoindoles; Male; Malondialdehyde; Organoselenium Compounds | 2014 |
Different dose-dependent effects of ebselen in sciatic nerve ischemia-reperfusion injury in rats.
Topics: Animals; Antioxidants; Apoptosis; Azoles; Dose-Response Relationship, Drug; Injections, Intraperiton | 2015 |
Selenium Pretreatment for Mitigation of Ischemia/Reperfusion Injury in Cardiovascular Surgery: Influence on Acute Organ Damage and Inflammatory Response.
Topics: Animals; Azoles; Cardiopulmonary Bypass; Dietary Supplements; Hypothermia, Induced; Inflammation; Is | 2016 |
Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion.
Topics: Animals; Antioxidants; Azoles; Brain Ischemia; Cerebral Arteries; Cerebrovascular Circulation; Disea | 2008 |
Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine.
Topics: Animals; Antioxidants; Azoles; Disease Models, Animal; Intestinal Diseases; Intestine, Small; Isoind | 2008 |
Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury.
Topics: Animals; Antioxidants; Azoles; Biomarkers; Glutathione Peroxidase; Intestinal Mucosa; Intestine, Sma | 2009 |
Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes.
Topics: 4-Aminobutyrate Transaminase; Animals; Azoles; Blotting, Western; Brain Ischemia; Cell Death; Gerbil | 2009 |
Beneficial effects of N-acetylcysteine and ebselen on renal ischemia/reperfusion injury.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Azoles; Drug Evaluation, Preclinical; Drug Therapy, Co | 2011 |
(-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors.
Topics: Animals; Azoles; Blood Urea Nitrogen; Catechin; Copper; Creatinine; Disease Models, Animal; Dose-Res | 2004 |
Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat.
Topics: Animals; Antioxidants; Azoles; bcl-2-Associated X Protein; Cell Death; Cells, Cultured; DNA, Complem | 2008 |
Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemia-reperfusion injury.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Azoles; Buthionine Sulfoxi | 1997 |
Oxidative and nitrosative stress in acute renal ischemia.
Topics: Animals; Azoles; Blotting, Western; Cell Line; Cyclic N-Oxides; DNA Damage; Enzyme Inhibitors; Free | 2001 |
Protection by seleno-organic compound, Ebselen, against acute gastric mucosal injury induced by ischemia-reperfusion in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Azoles; Catalase; Gastric Acid; Gast | 1990 |