Page last updated: 2024-10-26

ebselen and Reperfusion Injury

ebselen has been researched along with Reperfusion Injury in 18 studies

ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.

Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.

Research Excerpts

ExcerptRelevanceReference
" We compared the influence of a dietary surplus of Se and pretreatment with ebselen, a mimic of the selenoenzyme glutathione peroxidase, on IRI-induced tissue damage and inflammation."7.83Selenium Pretreatment for Mitigation of Ischemia/Reperfusion Injury in Cardiovascular Surgery: Influence on Acute Organ Damage and Inflammatory Response. ( Akhyari, P; Bilgic, E; Boeken, U; Döhrn, L; Engels, M; Kellermann, K; Lichtenberg, A; Pinto, A; Steinbrenner, H; Wollschläger, L, 2016)
" Therefore, we aimed to investigate the roles of N-acetylcysteine (NAC), a well-known powerful antioxidant, and ebselen (E), a scavenger of peroxynitrite, on renal injury induced by renal ischemia/reperfusion injury (IRI) of rat kidney."7.77Beneficial effects of N-acetylcysteine and ebselen on renal ischemia/reperfusion injury. ( Akgul, OE; Cakir, E; Cayci, T; Kizilgun, M; Kunak, ZI; Kurt, YG; Macit, E; Ozcan, A; Ozkan, E; Oztas, Y; Poyrazoglu, Y; Taslipinar, MY; Turker, T; Yaman, H; Yaren, H, 2011)
"The present study was designed to examine the in vivo effect of ebselen on reperfusion injury to the liver."7.69Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemia-reperfusion injury. ( Nakamura, M; Ota, K; Ozaki, M; Teraoka, S, 1997)
"Ebselen is an organic selenide that attenuates I/R injury in various organs."5.72Ebselen ameliorates renal ischemia-reperfusion injury via enhancing autophagy in rats. ( Chen, W; Pei, J; Shi, H; Song, S; Wu, Y; Xu, S; Xu, Y, 2022)
"Ebselen is an organoselenium compound which has strong antioxidant and anti-inflammatory effects."5.42Different dose-dependent effects of ebselen in sciatic nerve ischemia-reperfusion injury in rats. ( Akcer, S; Genc, O; Kocak, A; Kocak, C; Kocak, FE; Kucuk, A; Metineren, H; Ozyigit, F; Tosun, M, 2015)
"Ebselen has neuron-protective effects due to its antioxidant properties as shown by the decrease in MDA overproduction, increase in SOD activity and the histological improvement after administration of Ebselen to I/R in brain tissue."5.40Effects of ebselen on ischemia/reperfusion injury in rat brain. ( Altaş, M; Aras, M; Karcıoğlu, M; Meydan, S; Nacar, E; Serarslan, Y; Ulutaş, KT, 2014)
"Pretreatment with ebselen prevented the death by 56% and attenuated neurological damage (abnormal eyelid drooping, hair bristling, muscle tone, flexor reflex, posture, and walking patterns)."5.40Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils. ( Daily, JW; Kang, S; Kim, DS; Moon, NR; Park, S; Shin, BK, 2014)
"Both erdosteine and ebselen were able to attenuate I/R injury of the intestine via inhibition of lipid peroxidation and protein oxidation, maintenance of antioxidant, and free radical scavenger properties."5.35Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury. ( Atabek, C; Caliskan, B; Ersoz, N; Guven, A; Kesik, V; Oter, S; Oztas, E; Tunc, T; Uysal, B, 2009)
" We compared the influence of a dietary surplus of Se and pretreatment with ebselen, a mimic of the selenoenzyme glutathione peroxidase, on IRI-induced tissue damage and inflammation."3.83Selenium Pretreatment for Mitigation of Ischemia/Reperfusion Injury in Cardiovascular Surgery: Influence on Acute Organ Damage and Inflammatory Response. ( Akhyari, P; Bilgic, E; Boeken, U; Döhrn, L; Engels, M; Kellermann, K; Lichtenberg, A; Pinto, A; Steinbrenner, H; Wollschläger, L, 2016)
"Ebselen is used as a drug in clinical trials against stroke, reperfusion injury with anti-atherosclerotic and renoprotective effects."3.80Protective effect of ebselen on experimental testicular torsion and detorsion injury. ( Davarci, I; Davarci, M; Motor, S; Nacar, A; Rifaioglu, MM; Sefil, F; Tuzcu, K, 2014)
" Therefore, we aimed to investigate the roles of N-acetylcysteine (NAC), a well-known powerful antioxidant, and ebselen (E), a scavenger of peroxynitrite, on renal injury induced by renal ischemia/reperfusion injury (IRI) of rat kidney."3.77Beneficial effects of N-acetylcysteine and ebselen on renal ischemia/reperfusion injury. ( Akgul, OE; Cakir, E; Cayci, T; Kizilgun, M; Kunak, ZI; Kurt, YG; Macit, E; Ozcan, A; Ozkan, E; Oztas, Y; Poyrazoglu, Y; Taslipinar, MY; Turker, T; Yaman, H; Yaren, H, 2011)
"The present study was designed to examine the in vivo effect of ebselen on reperfusion injury to the liver."3.69Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemia-reperfusion injury. ( Nakamura, M; Ota, K; Ozaki, M; Teraoka, S, 1997)
"Ebselen is an organic selenide that attenuates I/R injury in various organs."1.72Ebselen ameliorates renal ischemia-reperfusion injury via enhancing autophagy in rats. ( Chen, W; Pei, J; Shi, H; Song, S; Wu, Y; Xu, S; Xu, Y, 2022)
"Ebselen is an organoselenium compound which has strong antioxidant and anti-inflammatory effects."1.42Different dose-dependent effects of ebselen in sciatic nerve ischemia-reperfusion injury in rats. ( Akcer, S; Genc, O; Kocak, A; Kocak, C; Kocak, FE; Kucuk, A; Metineren, H; Ozyigit, F; Tosun, M, 2015)
"Ebselen has neuron-protective effects due to its antioxidant properties as shown by the decrease in MDA overproduction, increase in SOD activity and the histological improvement after administration of Ebselen to I/R in brain tissue."1.40Effects of ebselen on ischemia/reperfusion injury in rat brain. ( Altaş, M; Aras, M; Karcıoğlu, M; Meydan, S; Nacar, E; Serarslan, Y; Ulutaş, KT, 2014)
"Pretreatment with ebselen prevented the death by 56% and attenuated neurological damage (abnormal eyelid drooping, hair bristling, muscle tone, flexor reflex, posture, and walking patterns)."1.40Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils. ( Daily, JW; Kang, S; Kim, DS; Moon, NR; Park, S; Shin, BK, 2014)
"Both erdosteine and ebselen were able to attenuate I/R injury of the intestine via inhibition of lipid peroxidation and protein oxidation, maintenance of antioxidant, and free radical scavenger properties."1.35Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury. ( Atabek, C; Caliskan, B; Ersoz, N; Guven, A; Kesik, V; Oter, S; Oztas, E; Tunc, T; Uysal, B, 2009)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (11.11)18.2507
2000's7 (38.89)29.6817
2010's7 (38.89)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Anzini, M1
Chelini, A1
Mancini, A1
Cappelli, A1
Frosini, M1
Ricci, L1
Valoti, M1
Magistretti, J1
Castelli, L1
Giordani, A1
Makovec, F1
Vomero, S1
Wu, Y2
Shi, H2
Xu, Y2
Pei, J1
Song, S1
Chen, W1
Xu, S2
Wen, R1
Gong, M1
Hong, G1
Aras, M1
Altaş, M1
Meydan, S1
Nacar, E1
Karcıoğlu, M1
Ulutaş, KT1
Serarslan, Y1
Park, S1
Kang, S1
Kim, DS1
Shin, BK1
Moon, NR1
Daily, JW1
Rifaioglu, MM1
Motor, S1
Davarci, I1
Tuzcu, K1
Sefil, F1
Davarci, M1
Nacar, A1
Ozyigit, F1
Kucuk, A1
Akcer, S1
Tosun, M1
Kocak, FE1
Kocak, C1
Kocak, A1
Metineren, H1
Genc, O1
Steinbrenner, H1
Bilgic, E1
Pinto, A1
Engels, M1
Wollschläger, L1
Döhrn, L1
Kellermann, K1
Boeken, U1
Akhyari, P1
Lichtenberg, A1
Wong, CH1
Bozinovski, S1
Hertzog, PJ1
Hickey, MJ1
Crack, PJ1
Guven, A2
Tunc, T2
Topal, T1
Kul, M1
Korkmaz, A1
Gundogdu, G1
Onguru, O1
Ozturk, H1
Uysal, B1
Atabek, C1
Kesik, V1
Caliskan, B1
Oztas, E1
Ersoz, N1
Oter, S1
Seo, JY1
Lee, CH1
Cho, JH1
Choi, JH1
Yoo, KY1
Kim, DW1
Park, OK1
Li, H1
Choi, SY1
Hwang, IK1
Won, MH1
Kizilgun, M1
Poyrazoglu, Y1
Oztas, Y1
Yaman, H1
Cakir, E1
Cayci, T1
Akgul, OE1
Kurt, YG1
Yaren, H1
Kunak, ZI1
Macit, E1
Ozkan, E1
Taslipinar, MY1
Turker, T1
Ozcan, A1
Yokozawa, T1
Rhyu, DY1
Cho, EJ1
Yamagata, K1
Ichinose, S1
Miyashita, A1
Tagami, M1
Ozaki, M1
Nakamura, M1
Teraoka, S1
Ota, K1
Noiri, E1
Nakao, A1
Uchida, K1
Tsukahara, H1
Ohno, M1
Fujita, T1
Brodsky, S1
Goligorsky, MS1
Ueda, S1
Yoshikawa, T1
Takahashi, S1
Naito, Y1
Oyamada, H1
Takemura, T1
Morita, Y1
Tanigawa, T1
Sugino, S1
Kondo, M1

Other Studies

18 other studies available for ebselen and Reperfusion Injury

ArticleYear
Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases.
    Journal of medicinal chemistry, 2010, Jan-28, Volume: 53, Issue:2

    Topics: Amidines; Animals; Antioxidants; Benzothiazoles; Brain Diseases; Calcium; Guanidines; Ion Transport;

2010
Ebselen ameliorates renal ischemia-reperfusion injury via enhancing autophagy in rats.
    Molecular and cellular biochemistry, 2022, Volume: 477, Issue:6

    Topics: Animals; Autophagy; Humans; Isoindoles; NF-E2-Related Factor 2; Organoselenium Compounds; Oxidative

2022
Selenoprotein Gene mRNA Expression Evaluation During Renal Ischemia-Reperfusion Injury in Rats and Ebselen Intervention Effects.
    Biological trace element research, 2023, Volume: 201, Issue:4

    Topics: Animals; Kidney; Mammals; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Selenium;

2023
Effects of ebselen on ischemia/reperfusion injury in rat brain.
    The International journal of neuroscience, 2014, Volume: 124, Issue:10

    Topics: Animals; Azoles; Brain; Brain Ischemia; Catalase; Disease Models, Animal; Glutathione Peroxidase; Is

2014
Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils.
    Free radical research, 2014, Volume: 48, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Brain Ischemia; Cell Survival; Cytokines;

2014
Protective effect of ebselen on experimental testicular torsion and detorsion injury.
    Andrologia, 2014, Volume: 46, Issue:10

    Topics: Animals; Antioxidants; Azoles; Catalase; Isoindoles; Male; Malondialdehyde; Organoselenium Compounds

2014
Different dose-dependent effects of ebselen in sciatic nerve ischemia-reperfusion injury in rats.
    Bosnian journal of basic medical sciences, 2015, Aug-26, Volume: 15, Issue:4

    Topics: Animals; Antioxidants; Apoptosis; Azoles; Dose-Response Relationship, Drug; Injections, Intraperiton

2015
Selenium Pretreatment for Mitigation of Ischemia/Reperfusion Injury in Cardiovascular Surgery: Influence on Acute Organ Damage and Inflammatory Response.
    Inflammation, 2016, Volume: 39, Issue:4

    Topics: Animals; Azoles; Cardiopulmonary Bypass; Dietary Supplements; Hypothermia, Induced; Inflammation; Is

2016
Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion.
    Journal of neurochemistry, 2008, Volume: 107, Issue:1

    Topics: Animals; Antioxidants; Azoles; Brain Ischemia; Cerebral Arteries; Cerebrovascular Circulation; Disea

2008
Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine.
    Surgery today, 2008, Volume: 38, Issue:11

    Topics: Animals; Antioxidants; Azoles; Disease Models, Animal; Intestinal Diseases; Intestine, Small; Isoind

2008
Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury.
    The Journal of surgical research, 2009, Volume: 155, Issue:2

    Topics: Animals; Antioxidants; Azoles; Biomarkers; Glutathione Peroxidase; Intestinal Mucosa; Intestine, Sma

2009
Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes.
    Journal of the neurological sciences, 2009, Oct-15, Volume: 285, Issue:1-2

    Topics: 4-Aminobutyrate Transaminase; Animals; Azoles; Blotting, Western; Brain Ischemia; Cell Death; Gerbil

2009
Beneficial effects of N-acetylcysteine and ebselen on renal ischemia/reperfusion injury.
    Renal failure, 2011, Volume: 33, Issue:5

    Topics: Acetylcysteine; Acute Kidney Injury; Animals; Azoles; Drug Evaluation, Preclinical; Drug Therapy, Co

2011
(-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors.
    The Journal of pharmacy and pharmacology, 2004, Volume: 56, Issue:2

    Topics: Animals; Azoles; Blood Urea Nitrogen; Catechin; Copper; Creatinine; Disease Models, Animal; Dose-Res

2004
Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat.
    Neuroscience, 2008, May-02, Volume: 153, Issue:2

    Topics: Animals; Antioxidants; Azoles; bcl-2-Associated X Protein; Cell Death; Cells, Cultured; DNA, Complem

2008
Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemia-reperfusion injury.
    Transplant international : official journal of the European Society for Organ Transplantation, 1997, Volume: 10, Issue:2

    Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Azoles; Buthionine Sulfoxi

1997
Oxidative and nitrosative stress in acute renal ischemia.
    American journal of physiology. Renal physiology, 2001, Volume: 281, Issue:5

    Topics: Animals; Azoles; Blotting, Western; Cell Line; Cyclic N-Oxides; DNA Damage; Enzyme Inhibitors; Free

2001
Protection by seleno-organic compound, Ebselen, against acute gastric mucosal injury induced by ischemia-reperfusion in rats.
    Advances in experimental medicine and biology, 1990, Volume: 264

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Azoles; Catalase; Gastric Acid; Gast

1990