ebselen has been researched along with Pancreatic Neoplasms in 5 studies
ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, we tested whether ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), a glutathione peroxidase mimicking compound, could counteract the effects of IL-1 beta, H2O2 and alloxan in rat pancreatic islets and in the rat insulinoma cell line RINm5F (RIN cells)." | 3.69 | Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells. ( de-Mello, MA; Eizirik, DL; Flodström, M, 1996) |
| "Ebselen treatment of pancreatic and renal cancer cell lines stalled tumor growth and inhibited invasion through Matrigel in vitro." | 1.42 | Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines. ( Borges, CR; Faigel, DO; Hanavan, PD; Ho, TH; Katchman, BA; Lake, DF; Ma, CT; Meurice, N; Petit, JL; Sergienko, EA, 2015) |
| "Ebselen is a seleno-organic compound that causes cell death in several cancer cell types." | 1.40 | The seleno-organic compound ebselen impairs mitochondrial physiology and induces cell death in AR42J cells. ( Fernandez-Bermejo, M; Garcia-Sanchez, L; Gonzalez, A; Ruy, DC; Salido, GM; Santofimia-Castaño, P, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Santofimia-Castaño, P | 2 |
| Izquierdo-Alvarez, A | 1 |
| Plaza-Davila, M | 1 |
| Martinez-Ruiz, A | 1 |
| Fernandez-Bermejo, M | 2 |
| Mateos-Rodriguez, JM | 1 |
| Salido, GM | 2 |
| Gonzalez, A | 2 |
| Garcia-Sanchez, L | 1 |
| Ruy, DC | 1 |
| Hanavan, PD | 1 |
| Borges, CR | 1 |
| Katchman, BA | 1 |
| Faigel, DO | 1 |
| Ho, TH | 1 |
| Ma, CT | 1 |
| Sergienko, EA | 1 |
| Meurice, N | 1 |
| Petit, JL | 1 |
| Lake, DF | 1 |
| de-Mello, MA | 1 |
| Flodström, M | 1 |
| Eizirik, DL | 1 |
| Sata, N | 1 |
| Klonowski-Stumpe, H | 1 |
| Han, B | 1 |
| Häussinger, D | 1 |
| Niederau, C | 1 |
5 other studies available for ebselen and Pancreatic Neoplasms
| Article | Year |
|---|---|
Ebselen impairs cellular oxidative state and induces endoplasmic reticulum stress and activation of crucial mitogen-activated protein kinases in pancreatic tumour AR42J cells.
Topics: Amylases; Animals; Azoles; Calcium; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Stress; G | 2018 |
The seleno-organic compound ebselen impairs mitochondrial physiology and induces cell death in AR42J cells.
Topics: Animals; Azoles; Calcium; Caspase 3; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Survival; Flow C | 2014 |
Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Blotting, Western; Ca | 2015 |
Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells.
Topics: Alloxan; Animals; Antioxidants; Azoles; Cytokines; Humans; Hydrogen Peroxide; Insulin; Insulinoma; I | 1996 |
Cytotoxicity of peroxynitrite in rat pancreatic acinar AR4-2J cells.
Topics: Animals; Antioxidants; Apoptosis; Azoles; Calcium; DNA Fragmentation; Dose-Response Relationship, Dr | 1997 |