ebselen has been researched along with Nerve Degeneration in 7 studies
ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ebselen was described to prevent glutamate-induced lipid peroxidation and cell death in cerebellar granule cells and (PhSe)(2) modify glutamatergic synapse parameters in vitro and in vivo." | 1.35 | Selenium compounds counteract the stimulation of ecto-nucleotidase activities in rat cultured cerebellar granule cells: putative correlation with neuroprotective effects. ( Boeck, CR; Ghisleni, G; Mioranzza, S; Porciúncula, LO; Rocha, JB; Souza, DO, 2008) |
| "Ebselen is a selenium compound that have glutathione peroxidase-like activity which is neuroprotective in acute stroke ischemia." | 1.31 | Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons. ( Boeck, CR; Porciúncula, LO; Rocha, JB; Souza, DO; Vendite, D, 2001) |
| "Ebselen (EBS) is a seleno-organic compound with glutathione peroxidase-like activity which is neuroprotective in acute stroke ischemia." | 1.31 | Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat. ( Mello, CF; Rocha, JB; Rossato, JI; Rubin, MA; Zeni, G, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghisleni, G | 1 |
| Porciúncula, LO | 2 |
| Mioranzza, S | 1 |
| Boeck, CR | 2 |
| Rocha, JB | 4 |
| Souza, DO | 2 |
| Zhu, P | 1 |
| DeCoster, MA | 1 |
| Bazan, NG | 1 |
| Centurião, FB | 1 |
| Corte, CL | 1 |
| Paixão, MW | 1 |
| Braga, AL | 1 |
| Zeni, G | 2 |
| Emanuelli, T | 1 |
| Yamasoba, T | 1 |
| Pourbakht, A | 1 |
| Sakamoto, T | 1 |
| Suzuki, M | 1 |
| Yamagata, K | 1 |
| Ichinose, S | 1 |
| Miyashita, A | 1 |
| Tagami, M | 1 |
| Vendite, D | 1 |
| Rossato, JI | 1 |
| Mello, CF | 1 |
| Rubin, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 2 Study of the Safety and Efficacy of an Oral Formulation of SPI-1005 for Prevention of Temporary Auditory Threshold Shift[NCT01444846] | Phase 2 | 83 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for ebselen and Nerve Degeneration
| Article | Year |
|---|---|
Selenium compounds counteract the stimulation of ecto-nucleotidase activities in rat cultured cerebellar granule cells: putative correlation with neuroprotective effects.
Topics: Adenosine Triphosphatases; Animals; Antioxidants; Azoles; Brain Damage, Chronic; Cells, Cultured; Ce | 2008 |
Interplay among platelet-activating factor, oxidative stress, and group I metabotropic glutamate receptors modulates neuronal survival.
Topics: Animals; Antioxidants; Azoles; Cell Death; Cell Survival; Cells, Cultured; Diterpenes; Excitatory Am | 2004 |
Effect of ebselen and organochalcogenides on excitotoxicity induced by glutamate in isolated chick retina.
Topics: Animals; Azoles; Benzene Derivatives; Calcium; Calcium Channels; Chalcogens; Chick Embryo; Dose-Resp | 2005 |
Ebselen prevents noise-induced excitotoxicity and temporary threshold shift.
Topics: Animals; Auditory Threshold; Azoles; Cochlear Nerve; Dendrites; Disease Models, Animal; Evoked Poten | 2005 |
Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat.
Topics: Animals; Antioxidants; Azoles; bcl-2-Associated X Protein; Cell Death; Cells, Cultured; DNA, Complem | 2008 |
Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons.
Topics: Animals; Animals, Newborn; Antioxidants; Azoles; Cell Survival; Cells, Cultured; Cerebellar Cortex; | 2001 |
Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat.
Topics: Animals; Azoles; Behavior, Animal; Brain Ischemia; Drug Interactions; Grooming; Isoindoles; Lipid Pe | 2002 |