ebselen has been researched along with Motor Neuron Disease in 2 studies
ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chantadul, V | 1 |
| Wright, GSA | 1 |
| Amporndanai, K | 1 |
| Shahid, M | 1 |
| Antonyuk, SV | 1 |
| Washbourn, G | 1 |
| Rogers, M | 1 |
| Roberts, N | 1 |
| Pye, M | 1 |
| O'Neill, PM | 1 |
| Hasnain, SS | 1 |
| Wood-Allum, CA | 1 |
| Barber, SC | 1 |
| Kirby, J | 1 |
| Heath, P | 1 |
| Holden, H | 1 |
| Mead, R | 1 |
| Higginbottom, A | 1 |
| Allen, S | 1 |
| Beaujeux, T | 1 |
| Alexson, SE | 1 |
| Ince, PG | 1 |
| Shaw, PJ | 1 |
2 other studies available for ebselen and Motor Neuron Disease
| Article | Year |
|---|---|
Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy.
Topics: Amino Acid Substitution; Azoles; Crystallography, X-Ray; Drug Design; Drug Discovery; Drug Evaluatio | 2020 |
Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen.
Topics: Animals; Antioxidants; Azoles; Blotting, Western; Cell Death; Cells, Cultured; Down-Regulation; Elec | 2006 |