ebselen has been researched along with Hypoxia in 11 studies
ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We hypothesized that ebselen via its ability to reduce reactive oxygen species (ROS) and augment nuclear factor-like 2 (Nrf2) anti-oxidants would attenuate hypoxia-induced damage to macroglial Müller cells and also lessen retinal vasculopathy." | 7.81 | Ebselen by modulating oxidative stress improves hypoxia-induced macroglial Müller cell and vascular injury in the retina. ( de Haan, JB; Deliyanti, D; Figgett, WA; Talia, DM; Tan, SM; Wilkinson-Berka, JL, 2015) |
| " We hypothesized that ebselen via its ability to reduce reactive oxygen species (ROS) and augment nuclear factor-like 2 (Nrf2) anti-oxidants would attenuate hypoxia-induced damage to macroglial Müller cells and also lessen retinal vasculopathy." | 3.81 | Ebselen by modulating oxidative stress improves hypoxia-induced macroglial Müller cell and vascular injury in the retina. ( de Haan, JB; Deliyanti, D; Figgett, WA; Talia, DM; Tan, SM; Wilkinson-Berka, JL, 2015) |
| "Rats treated with Ebselen and exposed to CIH displayed a significant reduction in 3-NT-ir levels (60." | 1.43 | Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation. ( Arias, P; Del Rio, R; Iturriaga, R; Moya, EA; Oyarce, MP; Varela, C, 2016) |
| "Ebselen (10 μM) was administered before the designated contractile period." | 1.39 | Low Po₂ conditions induce reactive oxygen species formation during contractions in single skeletal muscle fibers. ( Chien, MT; Hogan, MC; Roberts, WJ; Shiah, A; Wagner, PD; Zuo, L, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zuo, L | 1 |
| Shiah, A | 1 |
| Roberts, WJ | 1 |
| Chien, MT | 1 |
| Wagner, PD | 1 |
| Hogan, MC | 1 |
| Tan, SM | 1 |
| Deliyanti, D | 1 |
| Figgett, WA | 1 |
| Talia, DM | 1 |
| de Haan, JB | 1 |
| Wilkinson-Berka, JL | 1 |
| Moya, EA | 1 |
| Arias, P | 1 |
| Varela, C | 1 |
| Oyarce, MP | 1 |
| Del Rio, R | 1 |
| Iturriaga, R | 1 |
| Tajima, M | 1 |
| Kurashima, Y | 1 |
| Sugiyama, K | 1 |
| Ogura, T | 1 |
| Sakagami, H | 1 |
| Ahmad, M | 1 |
| Kelly, MR | 1 |
| Zhao, X | 1 |
| Kandhi, S | 1 |
| Wolin, MS | 1 |
| Agbani, EO | 1 |
| Coats, P | 1 |
| Wadsworth, RM | 1 |
| Degrossoli, A | 1 |
| Arrais-Silva, WW | 1 |
| Colhone, MC | 1 |
| Gadelha, FR | 1 |
| Joazeiro, PP | 1 |
| Giorgio, S | 1 |
| Zhu, X | 1 |
| Heunks, LM | 1 |
| Versteeg, EM | 1 |
| van der Heijden, HF | 1 |
| Ennen, L | 1 |
| van Kuppevelt, TH | 1 |
| Vina, J | 1 |
| Dekhuijzen, PN | 1 |
| Shi, H | 1 |
| Liu, S | 1 |
| Miyake, M | 1 |
| Liu, KJ | 1 |
| Yamagata, K | 1 |
| Ichinose, S | 1 |
| Miyashita, A | 1 |
| Tagami, M | 1 |
| Ali, MH | 1 |
| Schlidt, SA | 1 |
| Chandel, NS | 1 |
| Hynes, KL | 1 |
| Schumacker, PT | 1 |
| Gewertz, BL | 1 |
11 other studies available for ebselen and Hypoxia
| Article | Year |
|---|---|
Low Po₂ conditions induce reactive oxygen species formation during contractions in single skeletal muscle fibers.
Topics: Analysis of Variance; Animals; Antioxidants; Azoles; Electric Stimulation; Female; Hypoxia; In Vitro | 2013 |
Ebselen by modulating oxidative stress improves hypoxia-induced macroglial Müller cell and vascular injury in the retina.
Topics: Animals; Animals, Newborn; Antioxidants; Azoles; Biomarkers; Blotting, Western; Cells, Cultured; Dis | 2015 |
Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation.
Topics: Animals; Azoles; Blood Pressure; Carotid Body; Diastole; Hypertension; Hypoxia; Isoindoles; Male; Ne | 2016 |
The redox state of glutathione regulates the hypoxic induction of HIF-1.
Topics: Acetylcysteine; Animals; Azoles; Cell Line, Tumor; Enzyme Inhibitors; Glutathione; Glutathione Disul | 2009 |
Roles for Nox4 in the contractile response of bovine pulmonary arteries to hypoxia.
Topics: Animals; Antioxidants; Azoles; Cattle; Hypoxia; Isoindoles; Mitochondria, Muscle; Models, Animal; Mu | 2010 |
Acute hypoxia stimulates intracellular peroxynitrite formation associated with pulmonary artery smooth muscle cell proliferation.
Topics: Acute Disease; Animals; Azoles; Cattle; Cell Culture Techniques; Cell Hypoxia; Cell Proliferation; C | 2011 |
The influence of low oxygen on macrophage response to Leishmania infection.
Topics: Acetylcysteine; Animals; Azoles; Basic Helix-Loop-Helix Transcription Factors; Female; Free Radical | 2011 |
Hypoxia-induced dysfunction of rat diaphragm: role of peroxynitrite.
Topics: Animals; Azoles; Diaphragm; Enzyme Inhibitors; Hypoxia; In Vitro Techniques; Isoindoles; Lipid Perox | 2005 |
Ebselen induced C6 glioma cell death in oxygen and glucose deprivation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Azoles; Brain Ischemia; Cell Death; | 2006 |
Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat.
Topics: Animals; Antioxidants; Azoles; bcl-2-Associated X Protein; Cell Death; Cells, Cultured; DNA, Complem | 2008 |
Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction.
Topics: Antibodies; Antioxidants; Azoles; Cell Membrane Permeability; Cells, Cultured; Electric Impedance; E | 1999 |