Compounds > ebselen
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ebselen and Hypertension

ebselen has been researched along with Hypertension in 3 studies

ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
" We sought to investigate whether long-term administration of seleno-glutathione peroxidase mimic ebselen (PZ51) would have a protective effect on cortical neurons in SHRsp, and, if so, the possible mechanisms of this effect."5.33Protective effect of antioxidant ebselen (PZ51) on the cerebral cortex of stroke-prone spontaneously hypertensive rats. ( Liu, LS; Sui, H; Wang, PH; Wang, W, 2005)
"To investigate whether extrinsic antioxidant seleno-glutathione peroxidase mimic ebselen (PZ51) can protect endothelium and vascular structure of stroke-prone spontaneously hypertensive rats (SHRsp) during the chronic process of hypertension."3.73Effect of glutathione peroxidase mimic ebselen (PZ51) on endothelium and vascular structure of stroke-prone spontaneously hypertensive rats. ( Liu, LS; Sui, H; Wang, PH; Wang, W, 2005)
"Rats treated with Ebselen and exposed to CIH displayed a significant reduction in 3-NT-ir levels (60."1.43Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation. ( Arias, P; Del Rio, R; Iturriaga, R; Moya, EA; Oyarce, MP; Varela, C, 2016)
" We sought to investigate whether long-term administration of seleno-glutathione peroxidase mimic ebselen (PZ51) would have a protective effect on cortical neurons in SHRsp, and, if so, the possible mechanisms of this effect."1.33Protective effect of antioxidant ebselen (PZ51) on the cerebral cortex of stroke-prone spontaneously hypertensive rats. ( Liu, LS; Sui, H; Wang, PH; Wang, W, 2005)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Moya, EA1
Arias, P1
Varela, C1
Oyarce, MP1
Del Rio, R1
Iturriaga, R1
Sui, H2
Wang, W2
Wang, PH2
Liu, LS2

Other Studies

3 other studies available for ebselen and Hypertension

ArticleYear
Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation.
    Oxidative medicine and cellular longevity, 2016, Volume: 2016

    Topics: Animals; Azoles; Blood Pressure; Carotid Body; Diastole; Hypertension; Hypoxia; Isoindoles; Male; Ne

2016
Protective effect of antioxidant ebselen (PZ51) on the cerebral cortex of stroke-prone spontaneously hypertensive rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2005, Volume: 28, Issue:3

    Topics: Animals; Antioxidants; Azoles; Blood Pressure; Blotting, Western; Body Weight; Cerebral Cortex; Hype

2005
Effect of glutathione peroxidase mimic ebselen (PZ51) on endothelium and vascular structure of stroke-prone spontaneously hypertensive rats.
    Blood pressure, 2005, Volume: 14, Issue:6

    Topics: Animals; Antioxidants; Azoles; Blood Pressure; Blotting, Western; Body Weight; Carotid Arteries; End

2005