Page last updated: 2024-10-26

ebselen and Glioblastoma

ebselen has been researched along with Glioblastoma in 3 studies

ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.

Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.

Research Excerpts

ExcerptRelevanceReference
"We investigated the pro-inflammatory response mediated by TNFalpha in glioblastoma and whether treatment with organoselenium Ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]one) can affect TNFalpha induced inflammatory response."7.75Ebselen abrogates TNFalpha induced pro-inflammatory response in glioblastoma. ( Ghosh, A; Hossain Sk, U; Joseph, C; Koul, N; Sen, E; Sharma, V; Tewari, R, 2009)
"Cotreatment with Ebselen and TNFalpha induced G2/M phase arrest in cell cycle and modulated the expression of molecules involved in cell cycle progression."5.35Ebselen sensitizes glioblastoma cells to Tumor Necrosis Factor (TNFalpha)-induced apoptosis through two distinct pathways involving NF-kappaB downregulation and Fas-mediated formation of death inducing signaling complex. ( Joseph, C; Sen, E; Sharma, V; Sk, UH; Tewari, R, 2008)
"We investigated the pro-inflammatory response mediated by TNFalpha in glioblastoma and whether treatment with organoselenium Ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]one) can affect TNFalpha induced inflammatory response."3.75Ebselen abrogates TNFalpha induced pro-inflammatory response in glioblastoma. ( Ghosh, A; Hossain Sk, U; Joseph, C; Koul, N; Sen, E; Sharma, V; Tewari, R, 2009)
"Cotreatment with Ebselen and TNFalpha induced G2/M phase arrest in cell cycle and modulated the expression of molecules involved in cell cycle progression."1.35Ebselen sensitizes glioblastoma cells to Tumor Necrosis Factor (TNFalpha)-induced apoptosis through two distinct pathways involving NF-kappaB downregulation and Fas-mediated formation of death inducing signaling complex. ( Joseph, C; Sen, E; Sharma, V; Sk, UH; Tewari, R, 2008)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dukhande, VV1
Kawikova, I1
Bothwell, AL1
Lai, JC1
Sharma, V2
Tewari, R2
Sk, UH1
Joseph, C2
Sen, E2
Koul, N1
Ghosh, A1
Hossain Sk, U1

Other Studies

3 other studies available for ebselen and Glioblastoma

ArticleYear
Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione.
    Apoptosis : an international journal on programmed cell death, 2013, Volume: 18, Issue:6

    Topics: Apoptosis; Azoles; bcl-2-Associated X Protein; Buthionine Sulfoximine; Cell Line, Tumor; Cell Surviv

2013
Ebselen sensitizes glioblastoma cells to Tumor Necrosis Factor (TNFalpha)-induced apoptosis through two distinct pathways involving NF-kappaB downregulation and Fas-mediated formation of death inducing signaling complex.
    International journal of cancer, 2008, Nov-01, Volume: 123, Issue:9

    Topics: Apoptosis; Azoles; Cell Cycle; Cell Line, Tumor; Down-Regulation; fas Receptor; Fas-Associated Death

2008
Ebselen abrogates TNFalpha induced pro-inflammatory response in glioblastoma.
    Molecular oncology, 2009, Volume: 3, Issue:1

    Topics: Azoles; Cell Movement; DNA Repair; Gene Expression Regulation; Glioblastoma; Humans; Inflammation; I

2009