ebselen has been researched along with Experimental Mammary Neoplasms in 3 studies
ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The chemoprotective effects of combined ebselen and allopurinol in breast (MTLn3) and ovarian (NuTu-19) cancer models using a repeated cisplatin dosing schedule (6 mg/kg i." | 1.33 | Combined oral delivery of ebselen and allopurinol reduces multiple cisplatin toxicities in rat breast and ovarian cancer models while enhancing anti-tumor activity. ( Gu, R; Kil, J; Lynch, ED; Pierce, C, 2005) |
| "Treatment with ebselen did not reduce the antitumor activity of cisplatin against MPC 11 plasmacytoma or Prima breast tumor in BALB/c mice." | 1.28 | Selective reduction of cis-diamminedichloroplatinum(II) nephrotoxicity by ebselen. ( Baldew, GS; de Goeij, JJ; Los, G; McVie, JG; van der Valk, MA; Vermeulen, NP, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lynch, ED | 1 |
| Gu, R | 1 |
| Pierce, C | 1 |
| Kil, J | 1 |
| Ip, C | 1 |
| Ganther, HE | 1 |
| Baldew, GS | 1 |
| McVie, JG | 1 |
| van der Valk, MA | 1 |
| Los, G | 1 |
| de Goeij, JJ | 1 |
| Vermeulen, NP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety and Efficacy Study of SPI-1005 for Prevention of Chemotherapy Induced Hearing Loss[NCT01451853] | Phase 2 | 80 participants (Anticipated) | Interventional | 2018-01-15 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for ebselen and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Combined oral delivery of ebselen and allopurinol reduces multiple cisplatin toxicities in rat breast and ovarian cancer models while enhancing anti-tumor activity.
Topics: Administration, Oral; Allopurinol; Animals; Antineoplastic Agents; Azoles; Cell Line, Tumor; Chemopr | 2005 |
Activity of methylated forms of selenium in cancer prevention.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arsenic; Azoles; Betaine; Drug Synergism; Female; Isoindo | 1990 |
Selective reduction of cis-diamminedichloroplatinum(II) nephrotoxicity by ebselen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Azoles; Cisplatin; Drug Adm | 1990 |