Page last updated: 2024-10-26
ebselen and Drug-Induced Cochlear Toxicity
ebselen has been researched along with Drug-Induced Cochlear Toxicity in 1 studies
ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|
| "This mouse model of tobramycin-induced ototoxicity is clinically relevant in that it results in an incidence and severity of hearing loss recently documented in clinic." | 8.02 | Ebselen attenuates tobramycin-induced ototoxicity in mice. ( Gu, R; Homan, J; Kil, J; Longenecker, RJ, 2021) |
| "This mouse model of tobramycin-induced ototoxicity is clinically relevant in that it results in an incidence and severity of hearing loss recently documented in clinic." | 4.02 | Ebselen attenuates tobramycin-induced ototoxicity in mice. ( Gu, R; Homan, J; Kil, J; Longenecker, RJ, 2021) |
Research
Studies (1)
| Timeframe | Studies, this research(%) | All Research% |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
Authors
| Authors | Studies |
|---|
| Gu, R | 1 |
| Longenecker, RJ | 1 |
| Homan, J | 1 |
| Kil, J | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status |
|---|
| A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of SPI-1005 in Cystic Fibrosis (CF) Patients With Acute Pulmonary Exacerbation (APE) Receiving IV Tobramycin at Risk for Ototoxicity[NCT02819856] | Phase 2 | 80 participants (Anticipated) | Interventional | 2017-07-21 | Enrolling by invitation |
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Other Studies
1 other study available for ebselen and Drug-Induced Cochlear Toxicity
| Article | Year |
|---|
Ebselen attenuates tobramycin-induced ototoxicity in mice.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2021, Volume: 20, Issue:2
Topics: Animals; Evoked Potentials, Auditory, Brain Stem; Hair Cells, Auditory, Outer; Hearing Loss; Isoindo | 2021 |