ebselen has been researched along with Diabetic Glomerulosclerosis in 6 studies
ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of the GPx1-mimetic ebselen on diabetes-associated atherosclerosis and renal injury in a model of increased oxidative stress." | 3.76 | Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse. ( Chew, P; Cooper, ME; Coughlan, MT; de Haan, JB; Jandeleit-Dahm, KA; Pete, J; Rosenfeldt, F; Stefanovic, N; Thomas, MC; Yuen, DY, 2010) |
| " Current evidence suggests that a more nuanced approach to antioxidant therapy is more likely to yield positive reductions in end-organ injury, with considerations required for the types of ROS/RNS involved, the timing and dosage of antioxidant therapy, and the selective targeting of cell populations." | 2.52 | Are reactive oxygen species still the basis for diabetic complications? ( de Haan, JB; Di Marco, E; Jandeleit-Dahm, KA; Jha, JC; Sharma, A; Wilkinson-Berka, JL, 2015) |
| "Treatment with Ebselen partially prevented the decrease in capillary density and angiogenic competence of renal explants, and restored acetylcholine-induced vasorelaxation in 22-week-old ZDF rats." | 1.32 | Endothelial dysfunction as a modifier of angiogenic response in Zucker diabetic fat rat: amelioration with Ebselen. ( Brodsky, SV; Chander, PN; Friedli, C; Gealekman, O; Goligorsky, MS; Nasjletti, A; Zhang, F, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tan, SM | 2 |
| Sharma, A | 3 |
| Yuen, DY | 2 |
| Stefanovic, N | 3 |
| Krippner, G | 1 |
| Mugesh, G | 1 |
| Chai, Z | 1 |
| de Haan, JB | 4 |
| Di Marco, E | 1 |
| Jha, JC | 1 |
| Wilkinson-Berka, JL | 1 |
| Jandeleit-Dahm, KA | 2 |
| Chew, P | 1 |
| Pete, J | 1 |
| Coughlan, MT | 1 |
| Thomas, MC | 1 |
| Rosenfeldt, F | 1 |
| Cooper, ME | 1 |
| Chander, PN | 2 |
| Gealekman, O | 2 |
| Brodsky, SV | 2 |
| Elitok, S | 1 |
| Tojo, A | 1 |
| Crabtree, M | 1 |
| Gross, SS | 1 |
| Goligorsky, MS | 2 |
| Zhang, F | 1 |
| Friedli, C | 1 |
| Nasjletti, A | 1 |
1 review available for ebselen and Diabetic Glomerulosclerosis
| Article | Year |
|---|---|
Are reactive oxygen species still the basis for diabetic complications?
Topics: Animals; Antioxidants; Azoles; Blood Vessels; Diabetic Angiopathies; Diabetic Nephropathies; Diabeti | 2015 |
5 other studies available for ebselen and Diabetic Glomerulosclerosis
| Article | Year |
|---|---|
The modified selenenyl amide, M-hydroxy ebselen, attenuates diabetic nephropathy and diabetes-associated atherosclerosis in ApoE/GPx1 double knockout mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Azoles; Cell Line; Diabetes Mellitus, Experimental; Dia | 2013 |
Late-intervention study with ebselen in an experimental model of type 1 diabetic nephropathy.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Azoles; Deoxyguanosine; Diabetes Mellitus, Type | 2015 |
Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse.
Topics: Aldehydes; Animals; Antioxidants; Apolipoproteins E; Atherosclerosis; Azoles; Diabetes Mellitus, Exp | 2010 |
Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen.
Topics: Animals; Antioxidants; Azoles; Diabetic Nephropathies; Isoindoles; Nitrosation; Obesity; Organoselen | 2004 |
Endothelial dysfunction as a modifier of angiogenic response in Zucker diabetic fat rat: amelioration with Ebselen.
Topics: Acetylcholine; Animals; Antioxidants; Azoles; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dis | 2004 |