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ebselen and Cerebral Ischemia

ebselen has been researched along with Cerebral Ischemia in 22 studies

ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.

Research Excerpts

ExcerptRelevanceReference
"The effect of ebselen, a seleno-organic compound with antioxidant activity through a glutathione peroxidase-like action, on the outcome of subarachnoid hemorrhage was evaluated in a multicenter placebo-controlled double-blind clinical trial."9.08Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage. ( Abe, H; Asano, T; Ishibashi, S; Kikuchi, H; Ohta, T; Saito, I; Sano, K; Takakura, K; Yoshimoto, T, 1998)
"Ebselen has neuron-protective effects due to its antioxidant properties as shown by the decrease in MDA overproduction, increase in SOD activity and the histological improvement after administration of Ebselen to I/R in brain tissue."5.40Effects of ebselen on ischemia/reperfusion injury in rat brain. ( Altaş, M; Aras, M; Karcıoğlu, M; Meydan, S; Nacar, E; Serarslan, Y; Ulutaş, KT, 2014)
"Pretreatment with ebselen prevented the death by 56% and attenuated neurological damage (abnormal eyelid drooping, hair bristling, muscle tone, flexor reflex, posture, and walking patterns)."5.40Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils. ( Daily, JW; Kang, S; Kim, DS; Moon, NR; Park, S; Shin, BK, 2014)
"Ebselen is a mimic of glutathione peroxidase that reacts with peroxynitrite and inhibits nitric oxide (NO) synthase."5.37Neuroprotective effects of ebselen following forebrain ischemia: involvement of glutamate and nitric oxide. ( Fujisawa, H; Koizumi, H; Shirao, S; Suehiro, E; Suzuki, M, 2011)
"In ebselen-treated rats, the extent of tissue immunopositive for 8-oxodGuo, and 4-HNE was less than that demonstrating ischemic damage confirming the antioxidant mechanism of action in vivo."5.32Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia. ( Graham, DI; Imai, H; Macrae, IM; Masayasu, H, 2003)
"Pretreatment with ebselen, which induced significant (P < 0."5.32Single-dose ebselen does not afford sustained neuroprotection to rats subjected to severe focal cerebral ischemia. ( Alborch, E; Burguete, MC; Marín, N; Pérez-Asensio, FJ; Pitarch, C; Romero, FJ; Salom, JB; Torregrosa, G, 2004)
"Ebselen treatment resulted in a significant lowering of IL-6 plasma levels (26 +/- 5 pg/ml) as compared with that seen in lesioned vehicle controls (48 +/- 9 pg/ml) at 24 h postlesion."5.31Ebselen lowers plasma interleukin-6 levels and glial heme oxygenase-1 expression after focal photothrombotic brain ischemia. ( Arteel, GE; Bidmon, HJ; Divanach, A; Gladilin, S; Sies, H; Witte, OW; Zilles, K, 2000)
"The effect of ebselen, a seleno-organic compound with antioxidant activity through a glutathione peroxidase-like action, on the outcome of subarachnoid hemorrhage was evaluated in a multicenter placebo-controlled double-blind clinical trial."5.08Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage. ( Abe, H; Asano, T; Ishibashi, S; Kikuchi, H; Ohta, T; Saito, I; Sano, K; Takakura, K; Yoshimoto, T, 1998)
" Four compounds with free radical scavenging activity (tirilazad, ebselen, edaravone) or free radical trapping properties (NXY-059) have been examined in experimental models of stroke and evaluated clinically as neuroprotective agents."4.82Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers. ( Ashwood, T; Green, AR, 2005)
"LFB staining was used to detect demyelination."1.91Ebselen alleviates white matter lesions and improves cognitive deficits by attenuating oxidative stress via Keap1/Nrf2 pathway in chronic cerebral hypoperfusion mice. ( Cheng, B; Dong, F; Liu, Y; Meng, Q; Song, X; Yan, W; Yao, R, 2023)
"Ebselen has neuron-protective effects due to its antioxidant properties as shown by the decrease in MDA overproduction, increase in SOD activity and the histological improvement after administration of Ebselen to I/R in brain tissue."1.40Effects of ebselen on ischemia/reperfusion injury in rat brain. ( Altaş, M; Aras, M; Karcıoğlu, M; Meydan, S; Nacar, E; Serarslan, Y; Ulutaş, KT, 2014)
"Pretreatment with ebselen prevented the death by 56% and attenuated neurological damage (abnormal eyelid drooping, hair bristling, muscle tone, flexor reflex, posture, and walking patterns)."1.40Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils. ( Daily, JW; Kang, S; Kim, DS; Moon, NR; Park, S; Shin, BK, 2014)
"Ebselen is a mimic of glutathione peroxidase that reacts with peroxynitrite and inhibits nitric oxide (NO) synthase."1.37Neuroprotective effects of ebselen following forebrain ischemia: involvement of glutamate and nitric oxide. ( Fujisawa, H; Koizumi, H; Shirao, S; Suehiro, E; Suzuki, M, 2011)
"In ebselen-treated rats, the extent of tissue immunopositive for 8-oxodGuo, and 4-HNE was less than that demonstrating ischemic damage confirming the antioxidant mechanism of action in vivo."1.32Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia. ( Graham, DI; Imai, H; Macrae, IM; Masayasu, H, 2003)
"Pretreatment with ebselen, which induced significant (P < 0."1.32Single-dose ebselen does not afford sustained neuroprotection to rats subjected to severe focal cerebral ischemia. ( Alborch, E; Burguete, MC; Marín, N; Pérez-Asensio, FJ; Pitarch, C; Romero, FJ; Salom, JB; Torregrosa, G, 2004)
"Ebselen treatment resulted in a significant lowering of IL-6 plasma levels (26 +/- 5 pg/ml) as compared with that seen in lesioned vehicle controls (48 +/- 9 pg/ml) at 24 h postlesion."1.31Ebselen lowers plasma interleukin-6 levels and glial heme oxygenase-1 expression after focal photothrombotic brain ischemia. ( Arteel, GE; Bidmon, HJ; Divanach, A; Gladilin, S; Sies, H; Witte, OW; Zilles, K, 2000)
"Ebselen (EBS) is a seleno-organic compound with glutathione peroxidase-like activity which is neuroprotective in acute stroke ischemia."1.31Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat. ( Mello, CF; Rocha, JB; Rossato, JI; Rubin, MA; Zeni, G, 2002)
"3."1.30Neuroprotective efficacy of ebselen, an anti-oxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion. ( Graham, DI; Macrae, IM; Masayasu, H; Peters, EE; Takasago, T, 1997)
"Pretreatment with ebselen (10 or 30 mg/kg p."1.29The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat. ( Dawson, DA; Graham, DI; Macrae, IM; Masayasu, H, 1995)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (22.73)18.2507
2000's13 (59.09)29.6817
2010's3 (13.64)24.3611
2020's1 (4.55)2.80

Authors

AuthorsStudies
Kim, KM1
Kim, KH1
Kang, TC1
Kim, WY1
Lee, Mr1
Jung, HJ1
Hwang, IK2
Ko, SB1
Koh, JY1
Won, MH2
Oh, Eg1
Shin, I1
Dong, F1
Yan, W1
Meng, Q1
Song, X1
Cheng, B1
Liu, Y1
Yao, R1
Aras, M1
Altaş, M1
Meydan, S1
Nacar, E1
Karcıoğlu, M1
Ulutaş, KT1
Serarslan, Y1
Park, S1
Kang, S1
Kim, DS1
Shin, BK1
Moon, NR1
Daily, JW1
Wong, CH1
Bozinovski, S1
Hertzog, PJ1
Hickey, MJ1
Crack, PJ1
Seo, JY1
Lee, CH1
Cho, JH1
Choi, JH1
Yoo, KY1
Kim, DW1
Park, OK1
Li, H1
Choi, SY1
Bordet, R1
Ouk, T1
Onténiente, B1
Charriaut-Marlangue, C1
Heurteaux, C1
Koizumi, H1
Fujisawa, H1
Suehiro, E1
Shirao, S1
Suzuki, M1
Imai, H2
Graham, DI4
Masayasu, H5
Macrae, IM4
Salom, JB1
Pérez-Asensio, FJ1
Burguete, MC1
Marín, N1
Pitarch, C1
Torregrosa, G1
Romero, FJ1
Alborch, E1
Green, AR1
Ashwood, T1
Shi, H1
Liu, S1
Miyake, M1
Liu, KJ1
Dawson, DA1
Takasago, T1
Peters, EE1
Yamaguchi, T1
Sano, K2
Takakura, K3
Saito, I2
Shinohara, Y1
Asano, T3
Yasuhara, H1
Abe, H1
Yoshimoto, T1
Kikuchi, H1
Ohta, T1
Ishibashi, S1
Bastianetto, S1
Zheng, WH1
Quirion, R1
Gladilin, S1
Bidmon, HJ1
Divanach, A1
Arteel, GE1
Witte, OW1
Zilles, K1
Sies, H2
Parnham, M1
Dewar, D1
Rossato, JI1
Zeni, G1
Mello, CF1
Rubin, MA1
Rocha, JB1
Johshita, H1
Sasaki, T1
Matsui, T1
Hanamura, T1

Reviews

3 reviews available for ebselen and Cerebral Ischemia

ArticleYear
[Cerebral ischaemia: tomorrow's therapeutic tracks].
    Medecine sciences : M/S, 2009, Volume: 25, Issue:10

    Topics: Apoptosis; Astrocytes; Azoles; Brain Ischemia; Cerebral Infarction; Diagnosis, Differential; Endothe

2009
Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers.
    Current drug targets. CNS and neurological disorders, 2005, Volume: 4, Issue:2

    Topics: Animals; Antioxidants; Antipyrine; Azoles; Benzenesulfonates; Brain Ischemia; Edaravone; Free Radica

2005
Ebselen: prospective therapy for cerebral ischaemia.
    Expert opinion on investigational drugs, 2000, Volume: 9, Issue:3

    Topics: Animals; Antioxidants; Azoles; Brain Ischemia; Dogs; Humans; Isoindoles; Organoselenium Compounds; R

2000

Trials

2 trials available for ebselen and Cerebral Ischemia

ArticleYear
Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group.
    Stroke, 1998, Volume: 29, Issue:1

    Topics: Acute Disease; Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-S

1998
Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage.
    Neurosurgery, 1998, Volume: 42, Issue:2

    Topics: Aged; Antioxidants; Azoles; Brain Ischemia; Double-Blind Method; Female; Humans; Incidence; Intracra

1998

Other Studies

17 other studies available for ebselen and Cerebral Ischemia

ArticleYear
Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties.
    Bioorganic & medicinal chemistry letters, 2003, Jul-21, Volume: 13, Issue:14

    Topics: Animals; Antioxidants; Azoles; Brain Ischemia; Cell Death; Cell Survival; Drug Design; Electron Spin

2003
Ebselen alleviates white matter lesions and improves cognitive deficits by attenuating oxidative stress via Keap1/Nrf2 pathway in chronic cerebral hypoperfusion mice.
    Behavioural brain research, 2023, 06-25, Volume: 448

    Topics: Animals; Brain Ischemia; Carotid Stenosis; Cognition; Cognitive Dysfunction; Demyelinating Diseases;

2023
Effects of ebselen on ischemia/reperfusion injury in rat brain.
    The International journal of neuroscience, 2014, Volume: 124, Issue:10

    Topics: Animals; Azoles; Brain; Brain Ischemia; Catalase; Disease Models, Animal; Glutathione Peroxidase; Is

2014
Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils.
    Free radical research, 2014, Volume: 48, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Brain Ischemia; Cell Survival; Cytokines;

2014
Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion.
    Journal of neurochemistry, 2008, Volume: 107, Issue:1

    Topics: Animals; Antioxidants; Azoles; Brain Ischemia; Cerebral Arteries; Cerebrovascular Circulation; Disea

2008
Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes.
    Journal of the neurological sciences, 2009, Oct-15, Volume: 285, Issue:1-2

    Topics: 4-Aminobutyrate Transaminase; Animals; Azoles; Blotting, Western; Brain Ischemia; Cell Death; Gerbil

2009
Neuroprotective effects of ebselen following forebrain ischemia: involvement of glutamate and nitric oxide.
    Neurologia medico-chirurgica, 2011, Volume: 51, Issue:5

    Topics: Animals; Azoles; Brain Ischemia; CA1 Region, Hippocampal; Cerebrovascular Circulation; Disease Model

2011
Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia.
    Free radical biology & medicine, 2003, Jan-01, Volume: 34, Issue:1

    Topics: Animals; Antioxidants; Azoles; Brain Ischemia; Immunohistochemistry; Isoindoles; Male; Organoseleniu

2003
Single-dose ebselen does not afford sustained neuroprotection to rats subjected to severe focal cerebral ischemia.
    European journal of pharmacology, 2004, Jul-08, Volume: 495, Issue:1

    Topics: Administration, Oral; Animals; Azoles; Body Weight; Brain; Brain Chemistry; Brain Ischemia; Drug Adm

2004
Ebselen induced C6 glioma cell death in oxygen and glucose deprivation.
    Chemical research in toxicology, 2006, Volume: 19, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Azoles; Brain Ischemia; Cell Death;

2006
The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat.
    Neuroscience letters, 1995, Feb-06, Volume: 185, Issue:1

    Topics: Animals; Antioxidants; Azoles; Blood Pressure; Brain Ischemia; Caudate Nucleus; Cerebral Cortex; Dis

1995
Neuroprotective efficacy of ebselen, an anti-oxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion.
    British journal of pharmacology, 1997, Volume: 122, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Azoles; Brain Ischemia; Disease Mode

1997
The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C.
    Journal of neurochemistry, 2000, Volume: 74, Issue:6

    Topics: Alkaloids; Alzheimer Disease; Animals; Antioxidants; Azoles; Benzophenanthridines; Brain Ischemia; C

2000
Ebselen lowers plasma interleukin-6 levels and glial heme oxygenase-1 expression after focal photothrombotic brain ischemia.
    Archives of biochemistry and biophysics, 2000, Aug-15, Volume: 380, Issue:2

    Topics: Animals; Antioxidants; Azoles; Brain; Brain Ischemia; Heme Oxygenase (Decyclizing); Heme Oxygenase-1

2000
Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia.
    Stroke, 2001, Volume: 32, Issue:9

    Topics: Animals; Antioxidants; Axons; Azoles; Brain; Brain Ischemia; Disease Models, Animal; DNA Damage; Inf

2001
Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat.
    Neuroscience letters, 2002, Feb-01, Volume: 318, Issue:3

    Topics: Animals; Azoles; Behavior, Animal; Brain Ischemia; Drug Interactions; Grooming; Isoindoles; Lipid Pe

2002
Effects of ebselen (PZ51) on ischaemic brain oedema after focal ischaemia in cats.
    Acta neurochirurgica. Supplementum, 1990, Volume: 51

    Topics: Animals; Antioxidants; Azoles; Brain Edema; Brain Ischemia; Cats; Cerebrovascular Circulation; Isoin

1990