ebselen has been researched along with Bipolar Disorder in 6 studies
ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In/outpatients (n = 68) aged 18-70, experiencing mania or hypomania, were assigned to 3 weeks ebselen (600 mg bd) (n = 33) or placebo (n = 35)." | 9.34 | A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania. ( Cowen, PJ; Godlewska, BR; Holder, AA; MacDonald, O; Shanyinde, M; Sharpley, AL; Singh, N; Williams, C, 2020) |
| "Lithium is the most effective mood stabilizer for the treatment of bipolar disorder, but it is toxic at only twice the therapeutic dosage and has many undesirable side effects." | 7.79 | A safe lithium mimetic for bipolar disorder. ( Aley, PK; Antoniadou, I; Baldwin, R; Churchill, GC; Halliday, AC; Kuznetsova, OV; Sharp, T; Singh, N; Thomas, JM; Vasudevan, SR; Woon, EC, 2013) |
| " In/outpatients (n = 68) aged 18-70, experiencing mania or hypomania, were assigned to 3 weeks ebselen (600 mg bd) (n = 33) or placebo (n = 35)." | 5.34 | A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania. ( Cowen, PJ; Godlewska, BR; Holder, AA; MacDonald, O; Shanyinde, M; Sharpley, AL; Singh, N; Williams, C, 2020) |
| "Lithium is the most effective mood stabilizer for the treatment of bipolar disorder, but it is toxic at only twice the therapeutic dosage and has many undesirable side effects." | 3.79 | A safe lithium mimetic for bipolar disorder. ( Aley, PK; Antoniadou, I; Baldwin, R; Churchill, GC; Halliday, AC; Kuznetsova, OV; Sharp, T; Singh, N; Thomas, JM; Vasudevan, SR; Woon, EC, 2013) |
| "The study suggests that at the dosage used, ebselen can decrease impulsivity and produce a positive bias in emotional processing." | 2.82 | Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing. ( Churchill, GC; Cooper, CM; Cowen, PJ; Godlewska, BR; Harmer, CJ; Masaki, C; Rogers, RD; Sharp, T; Sharpley, AL; Singh, N; Vasudevan, SR, 2016) |
| "Ebselen is a synthetic organoselenium radical scavenger compound that possesses glutathione peroxidase-like activity and its own unique bioactivity by reacting with thiols, hydroperoxides and peroxynitrites." | 2.66 | Mechanisms of ebselen as a therapeutic and its pharmacology applications. ( Dong, C; Wang, J; Wang, P; Yuan, C; Zhao, Y; Zhou, J; Zou, L, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Sharpley, AL | 2 |
| Williams, C | 1 |
| Holder, AA | 1 |
| Godlewska, BR | 2 |
| Singh, N | 3 |
| Shanyinde, M | 1 |
| MacDonald, O | 1 |
| Cowen, PJ | 2 |
| Wang, J | 1 |
| Wang, P | 1 |
| Dong, C | 1 |
| Zhao, Y | 1 |
| Zhou, J | 1 |
| Yuan, C | 1 |
| Zou, L | 1 |
| Masaki, C | 1 |
| Cooper, CM | 1 |
| Vasudevan, SR | 2 |
| Harmer, CJ | 1 |
| Churchill, GC | 2 |
| Sharp, T | 2 |
| Rogers, RD | 1 |
| Nosengo, N | 1 |
| Pisanu, C | 1 |
| Melis, C | 1 |
| Squassina, A | 1 |
| Halliday, AC | 1 |
| Thomas, JM | 1 |
| Kuznetsova, OV | 1 |
| Baldwin, R | 1 |
| Woon, EC | 1 |
| Aley, PK | 1 |
| Antoniadou, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised, Parallel Group, Double Blind, Placebo Controlled, Add on Clinical Trial to Investigate Whether the Lithium Mimetic, Ebselen, Can Reduce Symptoms of Hypomania and Mania in Bipolar Patients[NCT03013400] | Phase 2 | 60 participants (Actual) | Interventional | 2017-10-01 | Completed | ||
| Does the IMPase Inhibitor, Ebselen, Affect Emotional Processing and Brain Myo-inositol in Treatment-resistant Depression?[NCT05117710] | Phase 1 | 50 participants (Anticipated) | Interventional | 2021-04-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ebselen and Bipolar Disorder
| Article | Year |
|---|---|
Mechanisms of ebselen as a therapeutic and its pharmacology applications.
Topics: Animals; Azoles; Bipolar Disorder; Cardiovascular Diseases; Hearing Loss, Sensorineural; Humans; Imm | 2020 |
Lithium Pharmacogenetics: Where Do We Stand?
Topics: Animals; Antimanic Agents; Azoles; Biomarkers; Bipolar Disorder; Humans; Isoindoles; Lithium Compoun | 2016 |
2 trials available for ebselen and Bipolar Disorder
| Article | Year |
|---|---|
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
Topics: Adult; Aged; Antimanic Agents; Azoles; Bipolar Disorder; Double-Blind Method; Drug Therapy, Combinat | 2020 |
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
Topics: Adult; Aged; Antimanic Agents; Azoles; Bipolar Disorder; Double-Blind Method; Drug Therapy, Combinat | 2020 |
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
Topics: Adult; Aged; Antimanic Agents; Azoles; Bipolar Disorder; Double-Blind Method; Drug Therapy, Combinat | 2020 |
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
Topics: Adult; Aged; Antimanic Agents; Azoles; Bipolar Disorder; Double-Blind Method; Drug Therapy, Combinat | 2020 |
Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.
Topics: Adult; Analysis of Variance; Animals; Azoles; Bipolar Disorder; Cross-Over Studies; Cyclooxygenase I | 2016 |
Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.
Topics: Adult; Analysis of Variance; Animals; Azoles; Bipolar Disorder; Cross-Over Studies; Cyclooxygenase I | 2016 |
Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.
Topics: Adult; Analysis of Variance; Animals; Azoles; Bipolar Disorder; Cross-Over Studies; Cyclooxygenase I | 2016 |
Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.
Topics: Adult; Analysis of Variance; Animals; Azoles; Bipolar Disorder; Cross-Over Studies; Cyclooxygenase I | 2016 |
2 other studies available for ebselen and Bipolar Disorder
| Article | Year |
|---|---|
Can you teach old drugs new tricks?
Topics: Animals; Azoles; Bipolar Disorder; Carbazoles; Clinical Trials, Phase II as Topic; Dipyridamole; Dru | 2016 |
A safe lithium mimetic for bipolar disorder.
Topics: Animals; Azoles; Behavior, Animal; Bipolar Disorder; Blood-Brain Barrier; Enzyme Inhibitors; Humans; | 2013 |