Page last updated: 2024-10-26

ebselen and Bipolar Disorder

ebselen has been researched along with Bipolar Disorder in 6 studies

ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.

Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.

Research Excerpts

ExcerptRelevanceReference
" In/outpatients (n = 68) aged 18-70, experiencing mania or hypomania, were assigned to 3 weeks ebselen (600 mg bd) (n = 33) or placebo (n = 35)."9.34A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania. ( Cowen, PJ; Godlewska, BR; Holder, AA; MacDonald, O; Shanyinde, M; Sharpley, AL; Singh, N; Williams, C, 2020)
"Lithium is the most effective mood stabilizer for the treatment of bipolar disorder, but it is toxic at only twice the therapeutic dosage and has many undesirable side effects."7.79A safe lithium mimetic for bipolar disorder. ( Aley, PK; Antoniadou, I; Baldwin, R; Churchill, GC; Halliday, AC; Kuznetsova, OV; Sharp, T; Singh, N; Thomas, JM; Vasudevan, SR; Woon, EC, 2013)
" In/outpatients (n = 68) aged 18-70, experiencing mania or hypomania, were assigned to 3 weeks ebselen (600 mg bd) (n = 33) or placebo (n = 35)."5.34A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania. ( Cowen, PJ; Godlewska, BR; Holder, AA; MacDonald, O; Shanyinde, M; Sharpley, AL; Singh, N; Williams, C, 2020)
"Lithium is the most effective mood stabilizer for the treatment of bipolar disorder, but it is toxic at only twice the therapeutic dosage and has many undesirable side effects."3.79A safe lithium mimetic for bipolar disorder. ( Aley, PK; Antoniadou, I; Baldwin, R; Churchill, GC; Halliday, AC; Kuznetsova, OV; Sharp, T; Singh, N; Thomas, JM; Vasudevan, SR; Woon, EC, 2013)
"The study suggests that at the dosage used, ebselen can decrease impulsivity and produce a positive bias in emotional processing."2.82Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing. ( Churchill, GC; Cooper, CM; Cowen, PJ; Godlewska, BR; Harmer, CJ; Masaki, C; Rogers, RD; Sharp, T; Sharpley, AL; Singh, N; Vasudevan, SR, 2016)
"Ebselen is a synthetic organoselenium radical scavenger compound that possesses glutathione peroxidase-like activity and its own unique bioactivity by reacting with thiols, hydroperoxides and peroxynitrites."2.66Mechanisms of ebselen as a therapeutic and its pharmacology applications. ( Dong, C; Wang, J; Wang, P; Yuan, C; Zhao, Y; Zhou, J; Zou, L, 2020)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (66.67)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Sharpley, AL2
Williams, C1
Holder, AA1
Godlewska, BR2
Singh, N3
Shanyinde, M1
MacDonald, O1
Cowen, PJ2
Wang, J1
Wang, P1
Dong, C1
Zhao, Y1
Zhou, J1
Yuan, C1
Zou, L1
Masaki, C1
Cooper, CM1
Vasudevan, SR2
Harmer, CJ1
Churchill, GC2
Sharp, T2
Rogers, RD1
Nosengo, N1
Pisanu, C1
Melis, C1
Squassina, A1
Halliday, AC1
Thomas, JM1
Kuznetsova, OV1
Baldwin, R1
Woon, EC1
Aley, PK1
Antoniadou, I1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomised, Parallel Group, Double Blind, Placebo Controlled, Add on Clinical Trial to Investigate Whether the Lithium Mimetic, Ebselen, Can Reduce Symptoms of Hypomania and Mania in Bipolar Patients[NCT03013400]Phase 260 participants (Actual)Interventional2017-10-01Completed
Does the IMPase Inhibitor, Ebselen, Affect Emotional Processing and Brain Myo-inositol in Treatment-resistant Depression?[NCT05117710]Phase 150 participants (Anticipated)Interventional2021-04-22Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for ebselen and Bipolar Disorder

ArticleYear
Mechanisms of ebselen as a therapeutic and its pharmacology applications.
    Future medicinal chemistry, 2020, Volume: 12, Issue:23

    Topics: Animals; Azoles; Bipolar Disorder; Cardiovascular Diseases; Hearing Loss, Sensorineural; Humans; Imm

2020
Lithium Pharmacogenetics: Where Do We Stand?
    Drug development research, 2016, Volume: 77, Issue:7

    Topics: Animals; Antimanic Agents; Azoles; Biomarkers; Bipolar Disorder; Humans; Isoindoles; Lithium Compoun

2016

Trials

2 trials available for ebselen and Bipolar Disorder

ArticleYear
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
    Psychopharmacology, 2020, Volume: 237, Issue:12

    Topics: Adult; Aged; Antimanic Agents; Azoles; Bipolar Disorder; Double-Blind Method; Drug Therapy, Combinat

2020
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
    Psychopharmacology, 2020, Volume: 237, Issue:12

    Topics: Adult; Aged; Antimanic Agents; Azoles; Bipolar Disorder; Double-Blind Method; Drug Therapy, Combinat

2020
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
    Psychopharmacology, 2020, Volume: 237, Issue:12

    Topics: Adult; Aged; Antimanic Agents; Azoles; Bipolar Disorder; Double-Blind Method; Drug Therapy, Combinat

2020
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
    Psychopharmacology, 2020, Volume: 237, Issue:12

    Topics: Adult; Aged; Antimanic Agents; Azoles; Bipolar Disorder; Double-Blind Method; Drug Therapy, Combinat

2020
Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.
    Psychopharmacology, 2016, Volume: 233, Issue:14

    Topics: Adult; Analysis of Variance; Animals; Azoles; Bipolar Disorder; Cross-Over Studies; Cyclooxygenase I

2016
Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.
    Psychopharmacology, 2016, Volume: 233, Issue:14

    Topics: Adult; Analysis of Variance; Animals; Azoles; Bipolar Disorder; Cross-Over Studies; Cyclooxygenase I

2016
Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.
    Psychopharmacology, 2016, Volume: 233, Issue:14

    Topics: Adult; Analysis of Variance; Animals; Azoles; Bipolar Disorder; Cross-Over Studies; Cyclooxygenase I

2016
Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.
    Psychopharmacology, 2016, Volume: 233, Issue:14

    Topics: Adult; Analysis of Variance; Animals; Azoles; Bipolar Disorder; Cross-Over Studies; Cyclooxygenase I

2016

Other Studies

2 other studies available for ebselen and Bipolar Disorder

ArticleYear
Can you teach old drugs new tricks?
    Nature, 2016, 06-16, Volume: 534, Issue:7607

    Topics: Animals; Azoles; Bipolar Disorder; Carbazoles; Clinical Trials, Phase II as Topic; Dipyridamole; Dru

2016
A safe lithium mimetic for bipolar disorder.
    Nature communications, 2013, Volume: 4

    Topics: Animals; Azoles; Behavior, Animal; Bipolar Disorder; Blood-Brain Barrier; Enzyme Inhibitors; Humans;

2013