ebselen has been researched along with Apoplexy in 8 studies
ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study indicates that ebselen may be neuroprotective when administered shortly after an embolic stroke, but the time- and dose-response analyses suggest that it has a narrow therapeutic window." | 7.72 | Ebselen, a seleno-organic antioxidant, is neuroprotective after embolic strokes in rabbits: synergism with low-dose tissue plasminogen activator. ( Lapchak, PA; Zivin, JA, 2003) |
| " We sought to investigate whether long-term administration of seleno-glutathione peroxidase mimic ebselen (PZ51) would have a protective effect on cortical neurons in SHRsp, and, if so, the possible mechanisms of this effect." | 5.33 | Protective effect of antioxidant ebselen (PZ51) on the cerebral cortex of stroke-prone spontaneously hypertensive rats. ( Liu, LS; Sui, H; Wang, PH; Wang, W, 2005) |
| "Radical scavenger compounds (such as Ebselen and Edaravone) are under clinical investigation as a therapeutic approach against stroke." | 4.91 | Pathophysiology and Treatments of Oxidative Injury in Ischemic Stroke: Focus on the Phagocytic NADPH Oxidase 2. ( Braunersreuther, V; Carbone, F; Mach, F; Montecucco, F; Teixeira, PC; Vuilleumier, N, 2015) |
| " Four compounds with free radical scavenging activity (tirilazad, ebselen, edaravone) or free radical trapping properties (NXY-059) have been examined in experimental models of stroke and evaluated clinically as neuroprotective agents." | 4.82 | Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers. ( Ashwood, T; Green, AR, 2005) |
| "This study indicates that ebselen may be neuroprotective when administered shortly after an embolic stroke, but the time- and dose-response analyses suggest that it has a narrow therapeutic window." | 3.72 | Ebselen, a seleno-organic antioxidant, is neuroprotective after embolic strokes in rabbits: synergism with low-dose tissue plasminogen activator. ( Lapchak, PA; Zivin, JA, 2003) |
| "Ebselen is a synthetic organoselenium radical scavenger compound that possesses glutathione peroxidase-like activity and its own unique bioactivity by reacting with thiols, hydroperoxides and peroxynitrites." | 2.66 | Mechanisms of ebselen as a therapeutic and its pharmacology applications. ( Dong, C; Wang, J; Wang, P; Yuan, C; Zhao, Y; Zhou, J; Zou, L, 2020) |
| " We sought to investigate whether long-term administration of seleno-glutathione peroxidase mimic ebselen (PZ51) would have a protective effect on cortical neurons in SHRsp, and, if so, the possible mechanisms of this effect." | 1.33 | Protective effect of antioxidant ebselen (PZ51) on the cerebral cortex of stroke-prone spontaneously hypertensive rats. ( Liu, LS; Sui, H; Wang, PH; Wang, W, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, J | 1 |
| Wang, P | 1 |
| Dong, C | 1 |
| Zhao, Y | 1 |
| Zhou, J | 1 |
| Yuan, C | 1 |
| Zou, L | 1 |
| Carbone, F | 1 |
| Teixeira, PC | 1 |
| Braunersreuther, V | 1 |
| Mach, F | 1 |
| Vuilleumier, N | 1 |
| Montecucco, F | 1 |
| Minnerup, J | 1 |
| Sutherland, BA | 1 |
| Buchan, AM | 1 |
| Kleinschnitz, C | 1 |
| Lapchak, PA | 1 |
| Zivin, JA | 1 |
| Green, AR | 1 |
| Ashwood, T | 1 |
| Sui, H | 1 |
| Wang, W | 1 |
| Wang, PH | 1 |
| Liu, LS | 1 |
| Yamagata, K | 1 |
| Ichinose, S | 1 |
| Miyashita, A | 1 |
| Tagami, M | 1 |
4 reviews available for ebselen and Apoplexy
| Article | Year |
|---|---|
Mechanisms of ebselen as a therapeutic and its pharmacology applications.
Topics: Animals; Azoles; Bipolar Disorder; Cardiovascular Diseases; Hearing Loss, Sensorineural; Humans; Imm | 2020 |
Pathophysiology and Treatments of Oxidative Injury in Ischemic Stroke: Focus on the Phagocytic NADPH Oxidase 2.
Topics: Animals; Antioxidants; Antipyrine; Azoles; Brain; Edaravone; Humans; Isoindoles; Membrane Glycoprote | 2015 |
Neuroprotection for stroke: current status and future perspectives.
Topics: Animals; Antioxidants; Azoles; Benzenesulfonates; Clinical Trials as Topic; Disease Models, Animal; | 2012 |
Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers.
Topics: Animals; Antioxidants; Antipyrine; Azoles; Benzenesulfonates; Brain Ischemia; Edaravone; Free Radica | 2005 |
4 other studies available for ebselen and Apoplexy
| Article | Year |
|---|---|
Ebselen could be used as anti-inflammatory Nox inhibitor.
Topics: Anti-Inflammatory Agents; Azoles; Catalytic Domain; Hearing Loss; Humans; Isoindoles; NADPH Oxidases | 2012 |
Ebselen, a seleno-organic antioxidant, is neuroprotective after embolic strokes in rabbits: synergism with low-dose tissue plasminogen activator.
Topics: Animals; Antioxidants; Azoles; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, | 2003 |
Protective effect of antioxidant ebselen (PZ51) on the cerebral cortex of stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Azoles; Blood Pressure; Blotting, Western; Body Weight; Cerebral Cortex; Hype | 2005 |
Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat.
Topics: Animals; Antioxidants; Azoles; bcl-2-Associated X Protein; Cell Death; Cells, Cultured; DNA, Complem | 2008 |