ebselen has been researched along with Amyotrophic Lateral Sclerosis in 4 studies
ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 3 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| McAlary, L | 2 |
| Shephard, VK | 1 |
| Wright, GSA | 2 |
| Yerbury, JJ | 3 |
| Amporndanai, K | 1 |
| Rogers, M | 1 |
| Watanabe, S | 1 |
| Yamanaka, K | 1 |
| O'Neill, PM | 2 |
| Hasnain, SS | 2 |
| Cashman, NR | 1 |
| Capper, MJ | 1 |
| Barbieri, L | 1 |
| Luchinat, E | 1 |
| Mercatelli, E | 1 |
| Antonyuk, SV | 1 |
| Banci, L | 1 |
4 other studies available for ebselen and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
A copper chaperone-mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Biomimetic Materials; Copper; Disulfides; Humans; Isoindoles; Molecul | 2022 |
Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Azoles; Betacoronavirus; Binding Sites; Cell Line, Tumor; Cr | 2020 |
Selenium-based compounds: Emerging players in the ever-unfolding story of SOD1 in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Azoles; Body Weight; Disease Models, Animal; Humans; Isoindo | 2020 |
The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.
Topics: Amyotrophic Lateral Sclerosis; Antioxidants; Asthma; Azoles; Crystallography, X-Ray; Cysteine; Disul | 2018 |