e-5090 has been researched along with Granuloma* in 1 studies
1 other study(ies) available for e-5090 and Granuloma
| Article | Year |
|---|---|
A novel inhibitor of IL-1 generation, E5090: in vivo inhibitory effect on the generation of IL-1-like factor and on granuloma formation in an air-pouch model.
The in vivo production of IL-1-like activity was investigated in the exudate of a rat air-pouch inflammatory model. An inflammatory reaction was induced by LPS injection into the air-pouch. IL-1 activity in the exudate reached the maximum level at 4 h and then rapidly decreased until 8 h after the injection of LPS. Orally administered E5090 and prednisolone dose-dependently inhibited the generation of IL-1 activity. Both compounds also suppressed chronic granuloma formation in parallel with the IL-1 inhibition. On the other hand, indomethacin had no effect on either IL-1 generation or granuloma formation in spite of the complete inhibition of PGE2 generation. These results suggest that E5090 inhibits the production of IL-1-like activity in the exudate and exhibits steroid-like antiinflammatory effects. Topics: Acrylates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Exudates and Transudates; Granuloma; Indomethacin; Interleukin-1; Male; Naphthols; Orosomucoid; Prednisolone; Rats; Rats, Inbred F344 | 1991 |