e 4031 has been researched along with Ventricular Fibrillation in 11 studies
E 4031: class III anti-arrhythmia agent; structure given in UD
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Compound 5 was shown to have good oral bioavailability and a favorable hemodynamic profile to produce a 3-fold increase of the ventricular fibrillation threshold and to terminate ventricular fibrillation, restoring sinus rhythm in anesthetized dogs." | 1.28 | Class III antiarrhythmic activity of novel substituted 4-[(methylsulfonyl)amino]benzamides and sulfonamides. ( Bagli, JF; Ellingboe, JW; Kitzen, JM; Moubarak, IF; Nguyen, TT; Parsons, RW; Spinelli, W; Von Engen, D; Winkley, MW, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (72.73) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ellingboe, JW | 1 |
| Spinelli, W | 2 |
| Winkley, MW | 1 |
| Nguyen, TT | 1 |
| Parsons, RW | 2 |
| Moubarak, IF | 1 |
| Kitzen, JM | 1 |
| Von Engen, D | 1 |
| Bagli, JF | 1 |
| Strauss, HC | 1 |
| Rasmusson, RL | 1 |
| Chi, L | 1 |
| Black, SC | 1 |
| Kuo, PI | 1 |
| Fagbemi, SO | 1 |
| Lucchesi, BR | 2 |
| Usui, M | 1 |
| Inoue, H | 1 |
| Saihara, S | 1 |
| Sugimoto, T | 1 |
| Murakawa, Y | 1 |
| Yamashita, T | 1 |
| Ajiki, K | 1 |
| Sezaki, K | 1 |
| Omata, M | 1 |
| Tachibana, H | 1 |
| Yamaki, M | 2 |
| Kubota, I | 2 |
| Watanabe, T | 2 |
| Yamauchi, S | 2 |
| Tomoike, H | 2 |
| Miyashita, T | 1 |
| Choi, BR | 1 |
| Liu, T | 1 |
| Salama, G | 1 |
| Colatsky, TJ | 1 |
| Holahan, MA | 1 |
| Stranieri, MT | 1 |
| Stabilito, II | 1 |
| Lynch, JJ | 1 |
| Chi, LG | 1 |
| Mu, DX | 1 |
11 other studies available for e 4031 and Ventricular Fibrillation
| Article | Year |
|---|---|
Class III antiarrhythmic activity of novel substituted 4-[(methylsulfonyl)amino]benzamides and sulfonamides.
Topics: Action Potentials; Anti-Arrhythmia Agents; Atrial Function; Benzamides; Benzimidazoles; Biological A | 1992 |
Restitution, ventricular fibrillation, and drugs: where are we now?
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Electrophysiologic Techniques, Cardiac; | 2002 |
Actions of pinacidil at a reduced potassium concentration: a direct cardiac effect possibly involving the ATP-dependent potassium channel.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Gu | 1993 |
Antifibrillatory effects of class III antiarrhythmic drugs: comparative study with flecainide.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Dogs; Electric Stimulati | 1993 |
Effects of a class III antiarrhythmic drug and biphasic shocks on the postdefibrillation refractory period of relatively refractory myocardium.
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Electric Countershock; Electric Stimulation; Heart; Piperidin | 1996 |
Intracoronary flecainide induces ST alternans and reentrant arrhythmia on intact canine heart: A role of 4-aminopyridine-sensitive current.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disopyrami | 1999 |
4-aminopyridine inhibits the occurrence of ventricular fibrillation but not ventricular tachycardia in the reperfused, P6olated rat heart.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Glyburide; Heart; Heart Rate; | 2000 |
The distribution of refractory periods influences the dynamics of ventricular fibrillation.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Female; Guinea Pigs; Heart Conduction System; He | 2001 |
Effects of WAY-123,398, a new class III antiarrhythmic agent, on cardiac refractoriness and ventricular fibrillation threshold in anesthetized dogs: a comparison with UK-68798, E-4031, and dl-sotalol.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Benzimidazoles; Dogs; Electrocar | 1992 |
Effect of E-4031, a class III antiarrhythmic agent, on experimental infarct size in a canine model of myocardial ischemia-reperfusion injury.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Dogs; Female; Hemodynamics; Male; Myocardial | 1992 |
Electrophysiology and antiarrhythmic actions of E-4031 in the experimental animal model of sudden coronary death.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Disease; Death, Sudden; Dogs; Electric Stimulation; Electr | 1991 |