e 4031 has been researched along with Disease Models, Animal in 19 studies
E 4031: class III anti-arrhythmia agent; structure given in UD
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of E 4031, a sodium calcium exchanger (NCX) agonist, on the isolated cardiac function and resting Ca2+ level in myocardial cells from rats with chronic heart failure." | 7.80 | [Effects of E 4031 on isolated cardiac function and resting Ca2+ level of myocardial cells from rats with chronic heart failure]. ( Bai, XJ; Hao, JT, 2014) |
| "Reperfusion arrhythmias were evaluated after a 5 minute occlusion period of the left main coronary artery." | 5.29 | Actions and interactions of E-4031 and tedisamil on reperfusion-induced arrhythmias and QT interval in rat in vivo. ( Bril, A; Gout, B; Landais, L, 1993) |
| "To investigate the effects of E 4031, a sodium calcium exchanger (NCX) agonist, on the isolated cardiac function and resting Ca2+ level in myocardial cells from rats with chronic heart failure." | 3.80 | [Effects of E 4031 on isolated cardiac function and resting Ca2+ level of myocardial cells from rats with chronic heart failure]. ( Bai, XJ; Hao, JT, 2014) |
| " In this study, we examined the role of hERG1 in colorectal carcinogenesis using two mouse models: adenomatous polyposis coli (Apc(min/+) ) and azoxymethane (AOM)-treated mice." | 3.79 | Characterization of hERG1 channel role in mouse colorectal carcinogenesis. ( Arcangeli, A; Caderni, G; Carraresi, L; De Lorenzo, E; Femia, AP; Fiore, A; Fortunato, A; Lastraioli, E; Morabito, A; Polvani, S, 2013) |
| "Glioblastoma is the most malignant primary brain tumor, with a median survival of less than 2 years." | 1.46 | Administration of Non-Torsadogenic human Ether-à-go-go-Related Gene Inhibitors Is Associated with Better Survival for High hERG-Expressing Glioblastoma Patients. ( Clark, PA; Eliceiri, KW; Kuo, JS; Pointer, KB; Robertson, GA; Salamat, MS, 2017) |
| "Invasion and metastasis are responsible for 90% of cancer-related mortality." | 1.42 | 4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent. From discovery to initial validation in an in vivo metastasis model. ( Bracke, ME; De Ryck, T; Katritzky, AR; Patronov, A; Roman, BI; Slavov, SH; Stevens, CV; Vanhoecke, BW, 2015) |
| "Arrhythmic outcome was defined as Torsade de Pointes (TdP) in the animal models and early afterdepolarizations (EADs) in the cell models." | 1.38 | Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes. ( Beekman, JD; de Boer, TP; Duker, G; Houtman, MJ; Jonsson, MK; Nalos, L; Peschar, M; Rook, MB; Sartipy, P; Thomsen, MB; van der Heyden, MA; van der Nagel, R; van Veen, TA; Varkevisser, R; Vos, MA, 2012) |
| "Inducibility of ventricular arrhythmias was examined by programmed stimulation." | 1.31 | Salutary antiarrhythmic effect of combining a K channel blocker and a beta-blocker in a canine model of 7-day-old myocardial infarction. ( Kanki, H; Mitamura, H; Ogawa, S; Sueyoshi, K; Takatsuki, S, 2000) |
| "The effects of congestive heart failure (CHF) on the ionic properties of PCs are unknown." | 1.31 | Ionic remodeling of cardiac Purkinje cells by congestive heart failure. ( Chartier, D; Han, W; Li, D; Nattel, S, 2001) |
| "Reperfusion arrhythmias were evaluated after a 5 minute occlusion period of the left main coronary artery." | 1.29 | Actions and interactions of E-4031 and tedisamil on reperfusion-induced arrhythmias and QT interval in rat in vivo. ( Bril, A; Gout, B; Landais, L, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Roman, BI | 1 |
| De Ryck, T | 1 |
| Patronov, A | 1 |
| Slavov, SH | 1 |
| Vanhoecke, BW | 1 |
| Katritzky, AR | 1 |
| Bracke, ME | 1 |
| Stevens, CV | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| El-Bizri, N | 1 |
| Li, CH | 1 |
| Liu, GX | 1 |
| Rajamani, S | 1 |
| Belardinelli, L | 2 |
| Ziupa, D | 1 |
| Menza, M | 1 |
| Koppermann, S | 1 |
| Moss, R | 1 |
| Beck, J | 1 |
| Franke, G | 1 |
| Perez Feliz, S | 1 |
| Brunner, M | 1 |
| Mayer, S | 1 |
| Bugger, H | 1 |
| Koren, G | 1 |
| Zehender, M | 1 |
| Jung, BA | 1 |
| Seemann, G | 1 |
| Foell, D | 1 |
| Bode, C | 1 |
| Odening, KE | 1 |
| Fiore, A | 1 |
| Carraresi, L | 1 |
| Morabito, A | 1 |
| Polvani, S | 1 |
| Fortunato, A | 1 |
| Lastraioli, E | 1 |
| Femia, AP | 1 |
| De Lorenzo, E | 1 |
| Caderni, G | 1 |
| Arcangeli, A | 1 |
| Bai, XJ | 1 |
| Hao, JT | 1 |
| Pointer, KB | 1 |
| Clark, PA | 1 |
| Eliceiri, KW | 1 |
| Salamat, MS | 1 |
| Robertson, GA | 1 |
| Kuo, JS | 1 |
| Wu, L | 1 |
| Ma, J | 1 |
| Li, H | 1 |
| Wang, C | 1 |
| Grandi, E | 1 |
| Zhang, P | 1 |
| Luo, A | 1 |
| Bers, DM | 1 |
| Shryock, JC | 1 |
| Nalos, L | 1 |
| Varkevisser, R | 1 |
| Jonsson, MK | 1 |
| Houtman, MJ | 1 |
| Beekman, JD | 1 |
| van der Nagel, R | 1 |
| Thomsen, MB | 1 |
| Duker, G | 1 |
| Sartipy, P | 1 |
| de Boer, TP | 1 |
| Peschar, M | 1 |
| Rook, MB | 1 |
| van Veen, TA | 1 |
| van der Heyden, MA | 1 |
| Vos, MA | 1 |
| Bussek, A | 1 |
| Schmidt, M | 1 |
| Bauriedl, J | 1 |
| Ravens, U | 1 |
| Wettwer, E | 1 |
| Lohmann, H | 1 |
| Fossa, AA | 1 |
| DePasquale, MJ | 1 |
| Raunig, DL | 1 |
| Avery, MJ | 1 |
| Leishman, DJ | 1 |
| Yamauchi, S | 1 |
| Yamaki, M | 1 |
| Watanabe, T | 1 |
| Yuuki, K | 1 |
| Kubota, I | 1 |
| Tomoike, H | 1 |
| Shiotani, M | 1 |
| Harada, T | 1 |
| Abe, J | 1 |
| Sawada, Y | 1 |
| Hashimoto, K | 1 |
| Hamada, Y | 1 |
| Horii, I | 1 |
| Ogawa, S | 2 |
| Mitamura, H | 2 |
| Katoh, H | 1 |
| Bril, A | 1 |
| Landais, L | 1 |
| Gout, B | 1 |
| Imamura, H | 1 |
| Furukawa, Y | 1 |
| Kasama, M | 1 |
| Hoyano, Y | 1 |
| Yonezawa, T | 1 |
| Chiba, S | 1 |
| Burashnikov, A | 1 |
| Antzelevitch, C | 1 |
| Takatsuki, S | 1 |
| Kanki, H | 1 |
| Sueyoshi, K | 1 |
| Han, W | 1 |
| Chartier, D | 1 |
| Li, D | 1 |
| Nattel, S | 1 |
19 other studies available for e 4031 and Disease Models, Animal
| Article | Year |
|---|---|
4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent. From discovery to initial validation in an in vivo metastasis model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Products; Cell Line, Tumor; Cell Movement; Ce | 2015 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Selective inhibition of physiological late Na
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial | 2018 |
Electro-mechanical (dys-)function in long QT syndrome type 1.
Topics: Action Potentials; Animals; Animals, Genetically Modified; Anti-Arrhythmia Agents; Biomechanical Phe | 2019 |
Characterization of hERG1 channel role in mouse colorectal carcinogenesis.
Topics: Adenomatous Polyposis Coli; Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colorectal Neoplasms | 2013 |
[Effects of E 4031 on isolated cardiac function and resting Ca2+ level of myocardial cells from rats with chronic heart failure].
Topics: Animals; Calcium; Disease Models, Animal; Heart; Heart Failure; In Vitro Techniques; Male; Myocardiu | 2014 |
Administration of Non-Torsadogenic human Ether-à-go-go-Related Gene Inhibitors Is Associated with Better Survival for High hERG-Expressing Glioblastoma Patients.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cel | 2017 |
Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization.
Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Bradycardia; Disease Models, Anima | 2011 |
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aza Compounds; Cell Line; Disease Models, Animal | 2012 |
Cardiac tissue slices with prolonged survival for in vitro drug safety screening.
Topics: 4-Aminopyridine; Action Potentials; Animal Testing Alternatives; Animals; Animals, Laboratory; Anti- | 2012 |
The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment.
Topics: Animals; Anti-Arrhythmia Agents; Butylamines; Cisapride; Disease Models, Animal; Dogs; Female; Heart | 2002 |
Restitution properties and occurrence of ventricular arrhythmia in LQT2 type of long QT syndrome.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disease Models, Animal; Disease Suscept | 2002 |
Practical application of guinea pig telemetry system for QT evaluation.
Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Bepridil; Cisapride; Disease Models, Animal; | 2005 |
Effect of E-4031, a new class III antiarrhythmic drug, on reentrant ventricular arrhythmias: comparison with conventional class I drugs.
Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disease Models, Animal; Disopyrami | 1993 |
Actions and interactions of E-4031 and tedisamil on reperfusion-induced arrhythmias and QT interval in rat in vivo.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Bridged Bicyclo Compounds; Br | 1993 |
Inhibition of delayed rectifier K+ current by dofetilide and E-4031 differentially affects electrical cardiac responses to vagus stimulation in anesthetized dogs.
Topics: Animals; Anti-Arrhythmia Agents; Bradycardia; Disease Models, Animal; Disopyramide; Dogs; Dose-Respo | 1998 |
Acceleration-induced action potential prolongation and early afterdepolarizations.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Disease Models, Animal | 1998 |
Salutary antiarrhythmic effect of combining a K channel blocker and a beta-blocker in a canine model of 7-day-old myocardial infarction.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, | 2000 |
Ionic remodeling of cardiac Purkinje cells by congestive heart failure.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Barium; Calcium; Calcium Channels, L-Type; Calci | 2001 |