e 4031 has been researched along with Arrhythmia in 38 studies
E 4031: class III anti-arrhythmia agent; structure given in UD
| Excerpt | Relevance | Reference |
|---|---|---|
| "Because the relative efficacy of antiarrhythmic agents on halothane-epinephrine arrhythmias has not been well characterized, this study was undertaken to comparatively evaluate the antiarrhythmic action of Na(+)-, K(+)- and Ca(2+)-channel blockers on epinephrine-induced ventricular arrhythmias during halothane anesthesia in rats." | 7.68 | Comparative efficacy of antiarrhythmic agents in preventing halothane-epinephrine arrhythmias in rats. ( Hayashi, Y; Kamibayashi, T; Kawabata, K; Sumikawa, K; Takada, K; Yamatodani, A; Yoshiya, I, 1993) |
| "Reperfusion arrhythmias were evaluated after a 5 minute occlusion period of the left main coronary artery." | 5.29 | Actions and interactions of E-4031 and tedisamil on reperfusion-induced arrhythmias and QT interval in rat in vivo. ( Bril, A; Gout, B; Landais, L, 1993) |
| "We designed the present study to examine whether diabetes mellitus affects the antiarrhythmic effect of flecainide, a sodium channel blocker, E-4031, a potassium channel blocker, and verapamil, a calcium channel blocker, in diabetic rats." | 3.73 | Diabetes mellitus reduces the antiarrhythmic effect of ion channel blockers. ( Hayashi, Y; Ito, I; Iwasaki, M; Kamibayashi, T; Kawai, Y; Mashimo, T; Takada, K; Yamatodani, A, 2006) |
| "Because the relative efficacy of antiarrhythmic agents on halothane-epinephrine arrhythmias has not been well characterized, this study was undertaken to comparatively evaluate the antiarrhythmic action of Na(+)-, K(+)- and Ca(2+)-channel blockers on epinephrine-induced ventricular arrhythmias during halothane anesthesia in rats." | 3.68 | Comparative efficacy of antiarrhythmic agents in preventing halothane-epinephrine arrhythmias in rats. ( Hayashi, Y; Kamibayashi, T; Kawabata, K; Sumikawa, K; Takada, K; Yamatodani, A; Yoshiya, I, 1993) |
| "Fluoxetine (Prozac) was more potent at blocking hERG 1a/1b than 1a channels, yielding a corresponding reduction in the safety margin." | 1.37 | hERG subunit composition determines differential drug sensitivity. ( Abi-Gerges, N; Holkham, H; Jones, EM; Pollard, CE; Robertson, GA; Valentin, JP, 2011) |
| "In contrast, atrial arrhythmia was inducible in only 2/11 transgenic mice." | 1.33 | Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity. ( Bellocq, C; Charpentier, F; Chevallier, JC; Clancy, CE; Demolombe, S; El Harchi, A; Escande, D; Lande, G; Le Quang, K; Loussouarn, G; Mazurais, D; Motoike, HK; Piron, J; Royer, A; Terrenoire, C; Toumaniantz, G, 2005) |
| "Inducibility of ventricular arrhythmias was examined by programmed stimulation." | 1.31 | Salutary antiarrhythmic effect of combining a K channel blocker and a beta-blocker in a canine model of 7-day-old myocardial infarction. ( Kanki, H; Mitamura, H; Ogawa, S; Sueyoshi, K; Takatsuki, S, 2000) |
| "However, the cycle length of the arrhythmia with quinidine was longer than that for control ([mean +/- SEM] 194 +/- 12 vs." | 1.30 | Optical mapping of drug-induced polymorphic arrhythmias and torsade de pointes in the isolated rabbit heart. ( Asano, Y; Baxter, WT; Davidenko, JM; Gray, RA; Jalife, J, 1997) |
| "Reperfusion arrhythmias were evaluated after a 5 minute occlusion period of the left main coronary artery." | 1.29 | Actions and interactions of E-4031 and tedisamil on reperfusion-induced arrhythmias and QT interval in rat in vivo. ( Bril, A; Gout, B; Landais, L, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (34.21) | 18.2507 |
| 2000's | 9 (23.68) | 29.6817 |
| 2010's | 15 (39.47) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, L | 1 |
| Sun, H | 1 |
| Brandão, KO | 1 |
| van den Brink, L | 1 |
| Miller, DC | 1 |
| Grandela, C | 1 |
| van Meer, BJ | 1 |
| Mol, MPH | 1 |
| de Korte, T | 1 |
| Tertoolen, LGJ | 1 |
| Mummery, CL | 1 |
| Sala, L | 1 |
| Verkerk, AO | 1 |
| Davis, RP | 1 |
| Li, M | 1 |
| Kanda, Y | 2 |
| Ashihara, T | 2 |
| Sasano, T | 1 |
| Nakai, Y | 1 |
| Kodama, M | 1 |
| Hayashi, E | 1 |
| Sekino, Y | 2 |
| Furukawa, T | 2 |
| Kurokawa, J | 2 |
| Luo, C | 2 |
| Wang, K | 2 |
| Zhang, H | 2 |
| El-Bizri, N | 1 |
| Li, CH | 1 |
| Liu, GX | 1 |
| Rajamani, S | 1 |
| Belardinelli, L | 1 |
| Odening, KE | 1 |
| Jung, BA | 1 |
| Lang, CN | 1 |
| Cabrera Lozoya, R | 1 |
| Ziupa, D | 1 |
| Menza, M | 1 |
| Relan, J | 1 |
| Franke, G | 1 |
| Perez Feliz, S | 1 |
| Koren, G | 1 |
| Zehender, M | 1 |
| Bode, C | 1 |
| Brunner, M | 1 |
| Sermesant, M | 1 |
| Föll, D | 1 |
| Wang, WL | 1 |
| Zhang, SS | 1 |
| Deng, J | 1 |
| Zhao, JY | 1 |
| Zhao, CQ | 1 |
| Lin, L | 1 |
| Zhang, CT | 1 |
| Lv, JG | 1 |
| Nakamura, Y | 2 |
| Matsuo, J | 1 |
| Miyamoto, N | 1 |
| Ojima, A | 1 |
| Ando, K | 1 |
| Sawada, K | 1 |
| Sugiyama, A | 1 |
| Zhang, JY | 1 |
| Cheng, K | 1 |
| Lai, D | 1 |
| Kong, LH | 1 |
| Shen, M | 1 |
| Yi, F | 1 |
| Liu, B | 1 |
| Wu, F | 1 |
| Zhou, JJ | 1 |
| Ahrens-Nicklas, RC | 1 |
| Christini, DJ | 1 |
| Yang, PC | 1 |
| Clancy, CE | 2 |
| Larsen, AP | 1 |
| Olesen, SP | 1 |
| Grunnet, M | 1 |
| Poelzing, S | 1 |
| Abi-Gerges, N | 1 |
| Holkham, H | 1 |
| Jones, EM | 1 |
| Pollard, CE | 1 |
| Valentin, JP | 1 |
| Robertson, GA | 1 |
| Vilums, M | 1 |
| Overman, J | 1 |
| Klaasse, E | 1 |
| Scheel, O | 1 |
| Brussee, J | 1 |
| IJzerman, AP | 1 |
| Kato, S | 1 |
| Honjo, H | 1 |
| Takemoto, Y | 1 |
| Takanari, H | 1 |
| Suzuki, T | 1 |
| Okuno, Y | 1 |
| Opthof, T | 1 |
| Sakuma, I | 1 |
| Inada, S | 1 |
| Nakazawa, K | 1 |
| Kodama, I | 1 |
| Kamiya, K | 1 |
| Borek, B | 1 |
| Shajahan, TK | 1 |
| Gabriels, J | 1 |
| Hodge, A | 1 |
| Glass, L | 1 |
| Shrier, A | 1 |
| Agarwal, A | 1 |
| Jing, L | 1 |
| Patwardhan, A | 1 |
| Royer, A | 1 |
| Demolombe, S | 1 |
| El Harchi, A | 1 |
| Le Quang, K | 1 |
| Piron, J | 1 |
| Toumaniantz, G | 1 |
| Mazurais, D | 1 |
| Bellocq, C | 1 |
| Lande, G | 1 |
| Terrenoire, C | 1 |
| Motoike, HK | 1 |
| Chevallier, JC | 1 |
| Loussouarn, G | 1 |
| Escande, D | 1 |
| Charpentier, F | 2 |
| Fossa, AA | 1 |
| Wisialowski, T | 1 |
| Crimin, K | 1 |
| Ito, I | 1 |
| Hayashi, Y | 2 |
| Kawai, Y | 1 |
| Iwasaki, M | 1 |
| Takada, K | 2 |
| Kamibayashi, T | 2 |
| Yamatodani, A | 2 |
| Mashimo, T | 1 |
| Mikhail, A | 1 |
| Fischer, C | 1 |
| Patel, A | 1 |
| Long, MA | 1 |
| Limberis, JT | 1 |
| Martin, RL | 1 |
| Cox, BF | 1 |
| Gintant, GA | 1 |
| Su, Z | 1 |
| Wang, Z | 1 |
| Fermini, B | 1 |
| Nattel, S | 1 |
| Ogawa, S | 4 |
| Mitamura, H | 2 |
| Katoh, H | 1 |
| Bril, A | 1 |
| Landais, L | 1 |
| Gout, B | 1 |
| Sumikawa, K | 1 |
| Kawabata, K | 1 |
| Yoshiya, I | 1 |
| Sadanaga, T | 1 |
| Okada, Y | 1 |
| Tsutsumi, N | 1 |
| Iwanaga, S | 1 |
| Yoshikawa, T | 1 |
| Akaishi, M | 1 |
| Handa, S | 1 |
| Asano, Y | 1 |
| Davidenko, JM | 1 |
| Baxter, WT | 1 |
| Gray, RA | 1 |
| Jalife, J | 1 |
| Pinto, JM | 1 |
| Boyden, PA | 1 |
| Shinmura, K | 1 |
| Tani, M | 1 |
| Hasegawa, H | 1 |
| Ebihara, Y | 1 |
| Nuss, HB | 1 |
| Marbán, E | 1 |
| Johns, DC | 1 |
| Tachibana, H | 1 |
| Yamaki, M | 1 |
| Kubota, I | 1 |
| Watanabe, T | 1 |
| Yamauchi, S | 1 |
| Tomoike, H | 1 |
| Tokuno, T | 1 |
| Muraki, K | 1 |
| Watanabe, M | 1 |
| Imaizumi, Y | 1 |
| Takatsuki, S | 1 |
| Kanki, H | 1 |
| Sueyoshi, K | 1 |
| Kondo, M | 1 |
| Tsutsumi, T | 1 |
| Mashima, S | 1 |
| Mérot, J | 1 |
| Probst, V | 1 |
| Debailleul, M | 1 |
| Gerlach, U | 1 |
| Moise, NS | 1 |
| Le Marec, H | 1 |
| Tahara, S | 1 |
| Fukuda, K | 1 |
| Kodama, H | 1 |
| Kato, T | 1 |
| Miyoshi, S | 1 |
38 other studies available for e 4031 and Arrhythmia
| Article | Year |
|---|---|
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant | 2008 |
Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias.
Topics: Arrhythmias, Cardiac; Cell Line; Electrophysiology; ERG1 Potassium Channel; Gene Editing; Genetic Pr | 2020 |
Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs.
Topics: Action Potentials; Arrhythmias, Cardiac; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Induced | 2017 |
In silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles.
Topics: Action Potentials; Arrhythmias, Cardiac; Cell Line; Disopyramide; Electrocardiography; ERG1 Potassiu | 2017 |
Modelling the effects of quinidine, disopyramide, and E-4031 on short QT syndrome variant 3 in the human ventricles.
Topics: Action Potentials; Arrhythmias, Cardiac; Disopyramide; Heart Conduction System; Heart Defects, Conge | 2017 |
Selective inhibition of physiological late Na
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial | 2018 |
Spatial correlation of action potential duration and diastolic dysfunction in transgenic and drug-induced LQT2 rabbits.
Topics: Action Potentials; Animals; Animals, Genetically Modified; Anti-Arrhythmia Agents; Arrhythmias, Card | 2013 |
KN-93, A CaMKII inhibitor, suppresses ventricular arrhythmia induced by LQT2 without decreasing TDR.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzylamines; Calcium-Calm | 2013 |
Assessment of testing methods for drug-induced repolarization delay and arrhythmias in an iPS cell-derived cardiomyocyte sheet: multi-site validation study.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cells, Cultured; Depressio | 2014 |
Cardiac sodium/calcium exchanger preconditioning promotes anti-arrhythmic and cardioprotective effects through mitochondrial calcium-activated potassium channel.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Ischemic Preconditioning; Male; Mitochondria; | 2015 |
Anthropomorphizing the mouse cardiac action potential via a novel dynamic clamp method.
Topics: Action Potentials; Algorithms; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Arrhythmias, Cardi | 2009 |
Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cells, Cultured; Computer | 2010 |
Pharmacological activation of IKr impairs conduction in guinea pig hearts.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial | 2010 |
hERG subunit composition determines differential drug sensitivity.
Topics: Action Potentials; Arrhythmias, Cardiac; Cell Line, Transformed; Drug Evaluation, Preclinical; Ether | 2011 |
Understanding of molecular substructures that contribute to hERG K+ channel blockade: synthesis and biological evaluation of E-4031 analogues.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans | 2012 |
Pharmacological blockade of IKs destabilizes spiral-wave reentry under β-adrenergic stimulation in favor of its early termination.
Topics: Action Potentials; Adrenergic Agents; Animals; Arrhythmias, Cardiac; Chromans; Heart Ventricles; Iso | 2012 |
Pacemaker interactions induce reentrant wave dynamics in engineered cardiac culture.
Topics: Animals; Arrhythmias, Cardiac; Chick Embryo; Heart; Models, Cardiovascular; Pacemaker, Artificial; P | 2012 |
Effect of rapid delayed rectifier current on hysteresis in restitution of action potential duration in swine.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Diastole; Electrophysiolog | 2012 |
Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blotting, Western; Cardiac | 2005 |
QT prolongation modifies dynamic restitution and hysteresis of the beat-to-beat QT-TQ interval relationship during normal sinus rhythm under varying states of repolarization.
Topics: Acetamides; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzodiazepino | 2006 |
Diabetes mellitus reduces the antiarrhythmic effect of ion channel blockers.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Diabetes Mellitus; Diabetes M | 2006 |
Hydroxypropyl beta-cyclodextrins: a misleading vehicle for the in vitro hERG current assay.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; beta-Cyclodextrins; | 2007 |
Rapid and slow components of delayed rectifier current in human atrial myocytes.
Topics: Arrhythmias, Cardiac; Cells, Cultured; Coronary Disease; Heart Atria; Humans; Membrane Potentials; M | 1994 |
Effect of E-4031, a new class III antiarrhythmic drug, on reentrant ventricular arrhythmias: comparison with conventional class I drugs.
Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disease Models, Animal; Disopyrami | 1993 |
Actions and interactions of E-4031 and tedisamil on reperfusion-induced arrhythmias and QT interval in rat in vivo.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Bridged Bicyclo Compounds; Br | 1993 |
Comparative efficacy of antiarrhythmic agents in preventing halothane-epinephrine arrhythmias in rats.
Topics: Amiodarone; Anesthesia, Inhalation; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Epinephri | 1993 |
Clinical evaluation of the use-dependent QRS prolongation and the reverse use-dependent QT prolongation of class I and class III antiarrhythmic agents and their value in predicting efficacy.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocar | 1993 |
Optical mapping of drug-induced polymorphic arrhythmias and torsade de pointes in the isolated rabbit heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Heart | 1997 |
Reduced inward rectifying and increased E-4031-sensitive K+ current density in arrhythmogenic subendocardial purkinje myocytes from the infarcted heart.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Ce | 1998 |
Effect of E4031, a class III antiarrhythmic drug, on ischemia- and reperfusion-induced arrhythmias in isolated rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Energy Metabolism; Heart; In Vitro T | 1998 |
Overexpression of a human potassium channel suppresses cardiac hyperexcitability in rabbit ventricular myocytes.
Topics: Action Potentials; Adenoviridae; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cation Trans | 1999 |
Intracoronary flecainide induces ST alternans and reentrant arrhythmia on intact canine heart: A role of 4-aminopyridine-sensitive current.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disopyrami | 1999 |
Effects of K+ channel modulators on the relationship between action potential duration and Ca2+ transients in single ventricular myocytes of the guinea pig.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cromakalim; Glybu | 1999 |
E 4031.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Delayed Rectifier Potassium Channels; Dogs; D | 1999 |
Salutary antiarrhythmic effect of combining a K channel blocker and a beta-blocker in a canine model of 7-day-old myocardial infarction.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, | 2000 |
Potassium channel openers antagonize the effects of class III antiarrhythmic agents in canine Purkinje fiber action potentials. Implications for prevention of proarrhythmia induced by class III agents.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Phenethylamines; Pip | 1999 |
Electropharmacological characterization of cardiac repolarization in German shepherd dogs with an inherited syndrome of sudden death: abnormal response to potassium channel blockers.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chromans; Death, Sudden, Cardiac; Dog Disease | 2000 |
Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium C | 2001 |