dynorphins and Psychotic-Disorders

dynorphins has been researched along with Psychotic-Disorders* in 2 studies

Reviews

1 review(s) available for dynorphins and Psychotic-Disorders

ArticleYear
Dynorphin/kappa-opioid receptor control of dopamine dynamics: Implications for negative affective states and psychiatric disorders.
    Brain research, 2019, 06-15, Volume: 1713

    Negative affective states are prevalent symptoms in a plethora of neuropsychiatric disorders, including depression and drug addiction. Dysfunction of mesocorticolimbic dopamine systems has been implicated in negative affective states in neuropsychiatric disorders. The dynorphin/kappa-opioid receptor system is a powerful effector of stress-related behavior and is highly enriched within the mesocorticolimbic dopamine system. Dysfunction of dynorphin/KOR signaling within the mesocorticolimbic dopamine system is implicated in promoting symptoms in neuropsychiatric disorders. As such, the kappa-opioid receptor system provides an important therapeutic target to treat negative affective states associated with psychiatric disorders. In this review, we provide a comprehensive overview of the dynorphin/kappa-opioid receptor system and its role in regulating the mesocorticolimbic dopamine system, motivation, and emotional behavior. Furthermore, we highlight unresolved issues in the field and offer some insights for future research.

    Topics: Affect; Animals; Dopamine; Dynorphins; Emotions; Humans; Mental Disorders; Psychotic Disorders; Receptors, Opioid, kappa; Signal Transduction

2019

Other Studies

1 other study(ies) available for dynorphins and Psychotic-Disorders

ArticleYear
The price of seizure control: dynorphins in interictal and postictal psychosis.
    Psychiatry research, 2007, May-30, Volume: 151, Issue:1-2

    Postictal and interictal psychoses are relatively common complicating factors in the clinical course of epilepsy, yet their neurobiological substrates are poorly understood. Recent evidence shows that kappa opioid receptor (KOR) activation elicits anticonvulsant and psychotomimetic effects. In view of this background, here we introduce the hypothesis that epilepsy-related psychoses may partially result from excessive hippocampal dynorphin release and kappa opioid receptor overstimulation aimed at seizure control.

    Topics: Animals; Anticonvulsants; Dynorphins; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kindling, Neurologic; Psychotic Disorders; Receptors, Opioid, kappa

2007