dynorphins has been researched along with Huntington-Disease* in 2 studies
2 other study(ies) available for dynorphins and Huntington-Disease
| Article | Year |
|---|---|
Peptides derived from prodynorphin are decreased in basal ganglia of Huntington's disease brains.
The contents of methionine-enkephalin-Arg-Gly-Leu, dynorphin A, dynorphin B and alpha-neoendorphin have been measured in both control and Huntington's disease brains obtained postmortem. All 4 peptides were significantly reduced in the caudate nucleus and putamen of Huntington's disease compared with the control group. No differences were observed in frontal cortex or hypothalamus. Immunocytochemistry showed a marked depletion of dynorphin-like immunoreactivity in Huntington's disease substantia nigra. Topics: Basal Ganglia; Caudate Nucleus; Dynorphins; Endorphins; Enkephalins; Globus Pallidus; Humans; Huntington Disease; Protein Precursors; Putamen; Substantia Nigra | 1986 |
Opioid peptides in Huntington's disease: alterations in prodynorphin and proenkephalin system.
The concentrations of dynorphin A1-8 and Met-enkephalin-Arg6-Gly7-Leu8 were measured in the basal ganglia of postmortem brains from patients with Huntington's disease (HD) and from control subjects. A significant reduction of dynorphin A1-8 concentration was found in caudate nucleus, putamen, external globus pallidus and substantia nigra of HD brains. Levels of Met-enkephalin-Arg6-Gly7-Leu8 were reduced in HD caudate nucleus, putamen, internal and external globus pallidus. These data indicate that both the prodynorphin and proenkephalin opioid peptide system are affected in the basal ganglia in HD. Topics: Basal Ganglia; Dynorphins; Enkephalin, Methionine; Female; Humans; Huntington Disease; In Vitro Techniques; Male; Middle Aged; Peptide Fragments; Substantia Nigra | 1986 |