dyclonine has been researched along with Friedreich Ataxia in 1 studies
Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Chronic dosing in a FA mouse model prevented a performance decline in balance beam studies." | 1.40 | Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia. ( Brown, B; Cortopassi, GA; Jasoliya, M; McMackin, MZ; Perlman, SL; Pook, MA; Sahdeo, S; Scott, BD; Wulff, H, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sahdeo, S | 1 |
| Scott, BD | 1 |
| McMackin, MZ | 1 |
| Jasoliya, M | 1 |
| Brown, B | 1 |
| Wulff, H | 1 |
| Perlman, SL | 1 |
| Pook, MA | 1 |
| Cortopassi, GA | 1 |
1 other study available for dyclonine and Friedreich Ataxia
| Article | Year |
|---|---|
Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia.
Topics: Aconitate Hydratase; Anesthetics, Local; Animals; Cell Line; Cerebellum; Frataxin; Friedreich Ataxia | 2014 |