dutasteride and Neoplasms

Prevention of cancer remains the most promising strategy for reducing both its incidence and the mortality due to this disease. For more than four decades, findings from epidemiology, basic research and clinical trials have informed the development of lifestyle and medical approaches to cancer prevention. These include selective oestrogen receptor modulators and aromatase inhibitors for breast cancer, the 5-α-reductase inhibitors finasteride and dutasteride for prostate cancer, and the development of vaccines for viruses that are associated with specific cancers. Future directions include genetic, proteomic and other molecular approaches for identifying pathways that are associated with cancer initiation and development, as well as refining the search for immunologically modifiable causes of cancer.

Topics: Aromatase Inhibitors; Azasteroids; Breast Neoplasms; Cancer Vaccines; Diet; Dutasteride; Female; Finasteride; Humans; Immunotherapy; Life Style; Male; Motor Activity; Neoplasms; Nicotiana; Obesity; Prostatic Neoplasms; Selective Estrogen Receptor Modulators; Vaccines

Topics: Animals; Azasteroids; Biomarkers, Tumor; Clinical Trials as Topic; Disease Models, Animal; Drug Approval; Dutasteride; Health; Humans; Male; Neoplasms; Prostatic Neoplasms; Reproducibility of Results; Risk Assessment; United States; United States Food and Drug Administration

Topics: Alopecia; Azasteroids; Drug Approval; Drug-Related Side Effects and Adverse Reactions; Dutasteride; Female; Finasteride; Humans; Male; Minoxidil; Neoplasms; Risk Factors; Time Factors