duloxetine hydrochloride has been researched along with Disease Models, Animal in 74 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (9.46) | 29.6817 |
| 2010's | 50 (67.57) | 24.3611 |
| 2020's | 17 (22.97) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Bornhorst, J; Brinkmann, V; Fritz, G; Honnen, S; Ventura, N; Wellenberg, A | 1 |
| Chen, H; Joseph, TP; Lin, SL; Sai, LY; Schachner, M; Zhou, F | 1 |
| Akazawa, T; Hagiwara, S; Inage, K; Kawarai, Y; Miyamoto, S; Nakajima, T; Nakamura, J; Ohtori, S; Orita, S; Suzuki, M; Suzuki, T | 1 |
| Kociszewski, J; Poleszak, E; Serefko, A; Szopa, A; Wiśniewski, R; Woźniak, A; Wróbel, A | 1 |
| Matta, C; Mensah-Nyagan, AG; Meyer, L; Taleb, O | 1 |
| Cao, L; Li, X; Wang, G; Xu, R; Yang, W; Yao, K; Zhang, J; Zhu, H | 1 |
| Bai, J; Jiang, S; Xia, R; Yan, L | 1 |
| Corradini, L; Imam, MZ; Kuo, A; Nicholson, JR; Smith, MT | 1 |
| Awtoniuk, M; Furgała-Wojas, A; Sałat, K; Sałat, R | 1 |
| Egashira, N; Kawashiri, T; Kobayashi, D; Nakamura, H; Shimazoe, T; Uchida, M | 1 |
| Badgaiyan, RD; Gupta, K; Jarrett, S; Palzer, EF; Sagi, V; Tran, H | 1 |
| Kim, S; Lee, DW; Park, HC; Schachner, M | 1 |
| Navratilova, E; Phelps, CE; Porreca, F | 1 |
| Corradini, L; Kuo, A; Nicholson, JR; Smith, MT | 1 |
| Furgała-Wojas, A; Sałat, K; Sałat, R | 1 |
| Barros, CM; Boralli, VB; Costa, LH; Galdino, G; Kawano, T; Placido, RV; Podesta, MHMC; Rodrigues, RF; Santos, RS | 1 |
| Micov, A; Pecikoza, U; Stepanović-Petrović, R; Tomić, M | 1 |
| Chen, M; Hoshino, H; Obata, H; Saito, S; Yang, Y | 1 |
| Chen, WJ; Li, W; Miao, B; Zhou, DM; Zhuang, Y | 1 |
| Blasco-Serra, A; Cervera-Ferri, A; González-Soler, EM; Teruel-Martí, V; Valverde-Navarro, AA | 1 |
| Di Cesare Mannelli, L; Farina, C; Ghelardini, C; Maresca, M; Micheli, L; Scherz, MW | 1 |
| Ali, J; Baboota, S; Iqbal, B; Kumar, S; Sindhu, P | 1 |
| Murai, N; Naito, M; Nakano, T; Ohmichi, M; Ohmichi, Y; Oshibuchi, H; Sato, J; Takeshita, N; Yasui, M | 1 |
| Funatsu, Y; Furutani, M; Kiso, T; Matsuda, R; Moriyama, A | 1 |
| Hama, A; Hayashi, I; Higo, N; Natsume, T; Ogawa, S; Takamatsu, H | 1 |
| An, L; Fan, QY; Fan, SY; Li, J; Li, YF; Ran, YH; Xue, R; Ye, CY; Zhang, LM; Zhang, TT; Zhang, YZ; Zhong, BH; Zhu, L | 1 |
| Alduntzin, U; Barrot, M; Ceredig, RA; Doridot, S; Gaveriaux-Ruff, C; Massotte, D; Pierre, F; Salvat, E; Yalcin, I | 1 |
| Inoue, K; Tozaki-Saitoh, H; Tsuda, M; Yamashita, T | 1 |
| Aygun, H; Esen, M | 1 |
| Awaga, Y; Hama, A; Hayashi, I; Magata, Y; Natsume, T; Ogawa, S; Okamoto, S; Shidahara, Y; Takamatsu, H; Yamoto, K | 1 |
| Abdelghany, AA; Arafa, EA; Bahr, HI; Barakat, BM; Fawzy, MS; Galhom, RA | 1 |
| Badghisi, H; Meske, DS; Ossipov, MH; Oyarzo, J; Porreca, F; Xie, JY | 1 |
| Kullmann, FA; Langdale, CL; Thor, KB; Wells, GI; Zheng, J | 1 |
| de Groat, WC; Matsuta, Y; Roppolo, JR; Schwen, Z; Shen, B; Tai, C; Wang, J | 1 |
| Budac, D; du Jardin, KG; Jensen, JB; Pehrson, AL; Sanchez, C; Smagin, G; Song, D | 1 |
| Authier, N; Balayssac, D; Eschalier, A; Ferrier, J; Ling, B; Pereira, B | 1 |
| Aoki, T; Matsuoka, N; Murai, N; Tamura, S; Tsukamoto, M | 1 |
| Castagné, V; Le Cudennec, C | 1 |
| Ishikawa, G; Nagakura, Y; Shimizu, Y; Takeshita, N | 1 |
| Aoki, T; Irie, M; Matsuoka, N; Murai, N; Nishigaki, F; Takeshita, N; Tamura, S | 1 |
| Aoki, T; Fushiki, H; Honda, S; Irie, M; Iwashita, A; Murai, N; Murakami, Y; Nagakura, Y; Tamura, S | 1 |
| Bannon, AW; Joshi, SK; Zhu, CZ | 1 |
| Bannister, K; Dickenson, AH; Goncalves, L; Patel, R; Townson, L | 1 |
| Russell, G; Strichartz, GR; Wang, CF; Wang, GK | 1 |
| Berquist, MD; Mooney-Leber, SM; Pehrson, AL; Porter, JH; Porter, NP; Prus, AJ | 1 |
| Itomi, Y; Kawamura, T; Tsukimi, Y | 1 |
| Averitt, DL; McLean, SA; Nyland, JE | 1 |
| Ahn, JH; Cho, JH; Choi, HS; Hong, S; Lee, CH; Park, JH; Won, MH | 1 |
| Allen, J; Cormier, J; Havelin, J; Imbert, I; King, T; Porreca, F | 1 |
| Liu, Y; Pan, B | 1 |
| Fan, QY; Fan, SY; He, XH; Li, J; Li, Y; Li, YF; Xue, R; Zhang, TT; Zhang, YZ; Zhong, BH | 1 |
| Cheng, W; Hu, J; Jiang, H; Li, X; Liu, M; Ma, Y; Sun, A; Wang, Q; Wang, Y; Zhang, X | 1 |
| Berrocoso, E; Mico, JA | 1 |
| Baker, SJ; Boyce-Rustay, JM; Decker, MW; Honore, P; Kohnken, R; Simler, GH; Wensink, EJ; Zhong, C | 1 |
| Dyhr, H; Grunnet, M; Munro, G | 1 |
| Dubner, R; Guo, W; Ren, K; Wang, H; Wei, F; Zou, S | 1 |
| Attali, P; Bienaymé, H; Ferté, J; Lluel, P; Ocaña, AV; Palea, S; Pérez-Martínez, FC; Rekik, M; Vela-Navarrete, R; Virseda, J | 1 |
| Courteix, C; Eschalier, A; Fialip, J; Libert, F; Loiodice, S; Privat, AM; Wattiez, AS | 1 |
| Marcus, DA | 1 |
| Bardin, L; Berrocoso, E; Depoortère, R; Ladure, P; Mico, JA; Newman-Tancredi, A; Vitton, O | 1 |
| Chen, NH; Li, J; Liu, Y; Sun, JD; Yuan, YH | 1 |
| Bannon, AW; Decker, MW; Gauvin, D; Hsieh, GC; Joshi, SK; Lee, CH; Lewis, LG; Mikusa, J; Mills, CD; Rueter, LE; Zhong, C; Zhu, CZ | 1 |
| Dyhr, H; Erichsen, HK; Hansen, MK; Marcher, L; Munro, G; Sheykhzade, M; Storm, A | 1 |
| Miyazaki, R; Yamamoto, T | 1 |
| Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y | 1 |
| Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ | 1 |
| Elmes, SJ; McIntosh, F; Perkins, MN; Rashid, MH; Theberge, Y | 1 |
| Hemrick-Luecke, SK; Iyengar, S; Simmons, RM; Webster, AA; Xu, JY | 1 |
| Moore, K | 1 |
| Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD | 1 |
| Leventhal, L; Piesla, M; Wantuch, C | 1 |
| Munro, G | 1 |
| Gilpin, NW; Ji, D; Koob, GF; Richardson, HN; Rivier, CL | 1 |
3 review(s) available for duloxetine hydrochloride and Disease Models, Animal
| Article | Year |
|---|---|
Gaps in Understanding Mechanism and Lack of Treatments: Potential Use of a Nonhuman Primate Model of Oxaliplatin-Induced Neuropathic Pain.
Topics: Analgesics; Animals; Antineoplastic Agents; Brain; Disease Models, Animal; Duloxetine Hydrochloride; Humans; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Primates | 2018 |
[Green Pharma: A New Strategy for Drug Discovery in Academia by Targeting Glial Cells and ATP Receptors].
Topics: Animals; Disease Models, Animal; Drug Discovery; Duloxetine Hydrochloride; Humans; Hyperalgesia; Injections, Spinal; Molecular Targeted Therapy; Neuralgia; Neuroglia; Purinergic P2X Receptor Antagonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X4 | 2018 |
Duloxetine: a new approach for treating stress urinary incontinence.
Topics: Adrenergic Uptake Inhibitors; Animals; Cats; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease Models, Animal; Duloxetine Hydrochloride; Female; Humans; Nausea; Quality of Life; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Thiophenes; Treatment Outcome; Urinary Incontinence, Stress | 2004 |
71 other study(ies) available for duloxetine hydrochloride and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Cisplatin-induced neurotoxicity involves the disruption of serotonergic neurotransmission.
Topics: Animals; Antineoplastic Agents; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cisplatin; Disease Models, Animal; Duloxetine Hydrochloride; Female; Gene Expression Regulation; Neurotoxicity Syndromes; Pharynx; Serotonin; Serotonin and Noradrenaline Reuptake Inhibitors; Synaptic Transmission | 2021 |
Duloxetine ameliorates valproic acid-induced hyperactivity, anxiety-like behavior, and social interaction deficits in zebrafish.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Duloxetine Hydrochloride; Prenatal Exposure Delayed Effects; Social Behavior; Social Interaction; Valproic Acid; Zebrafish | 2022 |
Analgesic Effect of Duloxetine on an Animal Model of Monosodium Iodoacetate-Induced Hip Osteoarthritis.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Drug Evaluation, Preclinical; Duloxetine Hydrochloride; Ganglia, Spinal; Hip Joint; Iodoacetic Acid; Male; Osteoarthritis, Hip; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn | 2020 |
Duloxetine reverses the symptoms of overactive bladder co-existing with depression via the central pathways.
Topics: Acetanilides; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Duloxetine Hydrochloride; Female; Locomotion; Rats; Rats, Wistar; Signal Transduction; Solifenacin Succinate; Thiazoles; Treatment Outcome; Urinary Bladder, Overactive; Urological Agents | 2020 |
Behavioral, Electrophysiological, and Histological Characterization of a New Rat Model for Neoadjuvant Chemotherapy-Induced Neuropathic Pain: Therapeutic Potential of Duloxetine and Allopregnanolone Concomitant Treatment.
Topics: Analgesics; Animals; Antineoplastic Agents; Disease Models, Animal; Docetaxel; Duloxetine Hydrochloride; Epirubicin; Female; Neoadjuvant Therapy; Neuralgia; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pregnanolone; Sciatic Nerve | 2020 |
DUOX2, a common modulator in preventive effects of monoamine-based antidepressants on water immersion restraint stress- and indomethacin- induced gastric mucosal damage.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Dual Oxidases; Duloxetine Hydrochloride; Gastric Mucosa; Immersion; Indomethacin; Male; NADPH Oxidases; Rats; Rats, Sprague-Dawley; Restraint, Physical; Serotonin and Noradrenaline Reuptake Inhibitors; Stomach Ulcer; Stress, Psychological | 2020 |
Successful Reversal of Opioid-Induced Hyperalgesia and Allodynia with Duloxetine.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Humans; Hyperalgesia; Morphine; Neuralgia | 2021 |
Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain.
Topics: Analgesics; Animals; Bone and Bones; Cancer Pain; Disease Models, Animal; Duloxetine Hydrochloride; Glycine Plasma Membrane Transport Proteins; Hyperalgesia; Male; Neuralgia; Pain Measurement; Pain Threshold; Pregabalin; Prostatic Neoplasms; Rats; Rats, Wistar | 2020 |
Wide-Range Measurement of Thermal Preference-A Novel Method for Detecting Analgesics Reducing Thermally-Evoked Pain in Mice.
Topics: Analgesics; Animals; Antineoplastic Agents; Cold Temperature; Disease Models, Animal; Duloxetine Hydrochloride; Hot Temperature; Hyperalgesia; Male; Mice; Oxaliplatin; Pain; Pain Measurement; Pregabalin; Temperature | 2021 |
Analgesic Effects of Sokeikakketsuto on Chemotherapy-Induced Mechanical Allodynia and Cold Hyperalgesia in Rats.
Topics: Analgesics; Animals; Antineoplastic Agents; Bortezomib; Cold Temperature; Disease Models, Animal; Drugs, Chinese Herbal; Duloxetine Hydrochloride; Humans; Hyperalgesia; Male; Medicine, Kampo; Oxaliplatin; Paclitaxel; Pain Measurement; Rats; Rats, Sprague-Dawley | 2021 |
Diet and companionship modulate pain via a serotonergic mechanism.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Animals; Chronic Pain; Diet; Disease Models, Animal; Duloxetine Hydrochloride; Female; Fenclonine; Hyperalgesia; Interpersonal Relations; Male; Mice; Mice, Transgenic; Morphine; Serotonin; Serotonin and Noradrenaline Reuptake Inhibitors; Serotonin Antagonists; Signal Transduction; Spinal Cord | 2021 |
Small compounds mimicking the adhesion molecule L1 improve recovery in a zebrafish demyelination model.
Topics: Animals; Cell Differentiation; Demyelinating Diseases; Disease Models, Animal; Duloxetine Hydrochloride; Larva; Lateral Line System; Motor Activity; Neural Cell Adhesion Molecule L1; Oligodendroglia; Regeneration; Remyelination; Schwann Cells; Small Molecule Libraries; Spinal Cord; Tacrine; Zebrafish | 2021 |
Chronic Pain Produces Reversible Memory Deficits That Depend on Task Difficulty in Rats.
Topics: Animals; Chronic Pain; Cognitive Dysfunction; Disease Models, Animal; Duloxetine Hydrochloride; Male; Neuralgia; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Recognition, Psychology; Serotonin and Noradrenaline Reuptake Inhibitors | 2021 |
Assessment of the Anti-Allodynic and Anti-Hyperalgesic Efficacy of a Glycine Transporter 2 Inhibitor Relative to Pregabalin, Duloxetine and Indomethacin in a Rat Model of Cisplatin-Induced Peripheral Neuropathy.
Topics: Analgesics; Animals; Benzamides; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Glycine Plasma Membrane Transport Proteins; Hyperalgesia; Indomethacin; Male; Peripheral Nervous System Diseases; Pregabalin; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2021 |
The Microglial Activation Inhibitor Minocycline, Used Alone and in Combination with Duloxetine, Attenuates Pain Caused by Oxaliplatin in Mice.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Behavior, Animal; Disease Models, Animal; Drug Combinations; Duloxetine Hydrochloride; Male; Mice; Microglia; Minocycline; Neuralgia; Oxaliplatin; Pain Threshold | 2021 |
Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats.
Topics: Amitriptyline; Analgesics; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Hyperalgesia; Male; Neuralgia; Pain Measurement; Pregabalin; Rats; Rats, Wistar | 2021 |
Levetiracetam synergizes with gabapentin, pregabalin, duloxetine and selected antioxidants in a mouse diabetic painful neuropathy model.
Topics: Amines; Analgesics; Animals; Anticonvulsants; Antioxidants; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Levetiracetam; Male; Mice; Mice, Inbred C57BL; Piracetam; Pregabalin | 2017 |
Spinal dopaminergic involvement in the antihyperalgesic effect of antidepressants in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclopropanes; Disease Models, Animal; Dopamine; Dopamine Antagonists; Duloxetine Hydrochloride; Fluoxetine; Hyperalgesia; Male; Milnacipran; Neuralgia; Pain Threshold; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Sulpiride | 2017 |
Effects of Duloxetine on the Toll-Like Receptor 4 Signaling Pathway in Spinal Dorsal Horn in a Rat Model of Diabetic Neuropathic Pain.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Duloxetine Hydrochloride; Pain Threshold; Rats; Signal Transduction; Spinal Cord Dorsal Horn; Toll-Like Receptor 4 | 2018 |
A standardization of the Novelty-Suppressed Feeding Test protocol in rats.
Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Male; Rats, Sprague-Dawley; Reproducibility of Results; Reserpine | 2017 |
A rat model of FOLFOX-induced neuropathy: effects of oral dimiracetam in comparison with duloxetine and pregabalin.
Topics: Administration, Oral; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Fluorouracil; Humans; Imidazoles; Neuralgia; Pregabalin; Pyrroles; Rats; Rats, Sprague-Dawley | 2017 |
Duloxetine loaded-microemulsion system to improve behavioral activities by upregulating serotonin and norepinephrine in brain for the treatment of depression.
Topics: Animals; Behavior, Animal; Biological Availability; Brain; Depression; Disease Models, Animal; Duloxetine Hydrochloride; Duodenum; Emulsions; Norepinephrine; Pharmaceutical Preparations; Rats; Serotonin; Serotonin and Noradrenaline Reuptake Inhibitors; Up-Regulation | 2018 |
Therapeutic effects of diclofenac, pregabalin, and duloxetine on disuse-induced chronic musculoskeletal pain in rats.
Topics: Animals; Chronic Pain; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Humans; Muscle, Skeletal; Muscular Disorders, Atrophic; Musculoskeletal Pain; Pain Measurement; Pain Threshold; Pregabalin; Rats; Rats, Sprague-Dawley | 2018 |
Effects of pregabalin and duloxetine on neurotransmitters in the dorsal horn of the spinal cord in a rat model of fibromyalgia.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Fibromyalgia; Male; Neurotransmitter Agents; Pregabalin; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn | 2018 |
Ammoxetine attenuates diabetic neuropathic pain through inhibiting microglial activation and neuroinflammation in the spinal cord.
Topics: Animals; Benzodioxoles; Calcium-Binding Proteins; Cell Line, Transformed; Diabetic Neuropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Exploratory Behavior; Hyperalgesia; Hypoglycemic Agents; Lipopolysaccharides; Locomotion; Microfilament Proteins; Microglia; Myelitis; Propylamines; Rats; Streptozocin | 2018 |
Peripheral delta opioid receptors mediate duloxetine antiallodynic effect in a mouse model of neuropathic pain.
Topics: Animals; Antidepressive Agents, Tricyclic; Disease Models, Animal; Duloxetine Hydrochloride; Female; Ganglia, Spinal; Hyperalgesia; Male; Mice, Transgenic; Neuralgia; Nortriptyline; Pain Measurement; Receptors, Opioid, delta; Sciatic Nerve | 2018 |
The effect of duloxetine on penicillin-induced epileptiform activity in rats.
Topics: Analysis of Variance; Animals; Brain Waves; Disease Models, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Electrocardiography; Epilepsy; Male; Penicillins; Rats; Rats, Wistar; Time Factors | 2019 |
Distinguishing analgesic drugs from non-analgesic drugs based on brain activation in macaques with oxaliplatin-induced neuropathic pain.
Topics: Analgesics; Animals; Antineoplastic Agents; Brain; Cerebral Cortex; Cryopyrin-Associated Periodic Syndromes; Disease Models, Animal; Duloxetine Hydrochloride; Macaca fascicularis; Magnetic Resonance Imaging; Male; Neuralgia; Oxaliplatin; Pregabalin; Somatosensory Cortex; Tramadol | 2019 |
Duloxetine protects against experimental diabetic retinopathy in mice through retinal GFAP downregulation and modulation of neurotrophic factors.
Topics: Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Down-Regulation; Duloxetine Hydrochloride; Glial Fibrillary Acidic Protein; Male; Mice; Nerve Growth Factors; Neuroprotective Agents; Retina | 2019 |
Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Male; Morphine; Neuralgia; Norepinephrine; Pain Measurement; Phenols; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Nerves; Tapentadol; Thiophenes | 2014 |
Stability of the acetic acid-induced bladder irritation model in alpha chloralose-anesthetized female cats.
Topics: Acetic Acid; Adrenergic Uptake Inhibitors; Anesthesia; Animals; Blood Pressure; Cats; Chloralose; Disease Models, Animal; Duloxetine Hydrochloride; Electromyography; Female; Heart Rate; Humans; Hypnotics and Sedatives; Muscle Contraction; Respiration; Thiophenes; Time Factors; Urethra; Urinary Bladder; Urinary Bladder Diseases; Urination | 2013 |
Inhibition of bladder overactivity by duloxetine in combination with foot stimulation or WAY-100635 treatment in cats.
Topics: Animals; Cats; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Duloxetine Hydrochloride; Electric Stimulation Therapy; Female; Foot; Male; Piperazines; Pyridines; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Thiophenes; Urinary Bladder; Urinary Bladder, Overactive | 2013 |
Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct 5-HT receptor modulation.
Topics: 5-Hydroxytryptophan; Animals; Carbidopa; Citalopram; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Exploratory Behavior; Female; Hippocampus; Maze Learning; Memory Disorders; Phenylalanine; Piperazines; Protein Binding; Rats; Rats, Long-Evans; Recognition, Psychology; Selective Serotonin Reuptake Inhibitors; Serotonin; Sulfides; Thiophenes; Vortioxetine | 2014 |
Assessment of thermal sensitivity in rats using the thermal place preference test: description and application in the study of oxaliplatin-induced acute thermal hypersensitivity and inflammatory pain models.
Topics: Analgesics; Analgesics, Opioid; Animals; Carrageenan; Cold Temperature; Conditioning, Psychological; Disease Models, Animal; Duloxetine Hydrochloride; Hot Temperature; Hyperalgesia; Male; Morphine; Organoplatinum Compounds; Oxaliplatin; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Space Perception; Temperature; Thiophenes | 2014 |
Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Hyperalgesia; Injections, Spinal; Male; Mice, Inbred ICR; Morpholines; Neuralgia; Prostaglandins; Spinal Cord; Stereoisomerism; Thiophenes | 2014 |
Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine.
Topics: Analgesics; Animals; Cold Temperature; Disease Models, Animal; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Male; Neuralgia; Physical Stimulation; Pregabalin; Rats, Wistar; Sciatic Nerve; Thiophenes; Tramadol | 2014 |
Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Duloxetine Hydrochloride; Gait; Iodoacetic Acid; Male; Morphine; Movement; Osteoarthritis; Pain; Rats; Rest; Thiophenes; Tramadol; Weight-Bearing | 2014 |
AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in rat models of nociceptive pain.
Topics: Analgesics; Animals; Arthralgia; Arthritis, Experimental; Bradykinin; Chronic Disease; Disease Models, Animal; Duloxetine Hydrochloride; Female; Male; Morpholines; Nociceptive Pain; Pain Measurement; Rats, Inbred Lew; Rats, Sprague-Dawley; Time Factors | 2015 |
Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats.
Topics: Analgesics; Animals; Brain; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Hyperalgesia; Male; Morpholines; Myalgia; Pain Threshold; Pressure; Rats, Sprague-Dawley; Reserpine; Serotonin Plasma Membrane Transport Proteins; Treatment Outcome | 2015 |
Complete Freund's adjuvant-induced reduction of exploratory activity in a novel environment as an objective nociceptive endpoint for sub-acute inflammatory pain model in rats.
Topics: Adjuvants, Immunologic; Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Freund's Adjuvant; Gabapentin; gamma-Aminobutyric Acid; Ibuprofen; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley | 2015 |
Diffuse noxious inhibitory controls and nerve injury: restoring an imbalance between descending monoamine inhibitions and facilitations.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Antagonists; Analysis of Variance; Animals; Biogenic Monoamines; Diffuse Noxious Inhibitory Control; Disease Models, Animal; Duloxetine Hydrochloride; Evoked Potentials; Male; Neurons; Ondansetron; Peripheral Nerve Injuries; Phenols; Rats; Rats, Sprague-Dawley; Recovery of Function; Serotonin and Noradrenaline Reuptake Inhibitors; Serotonin Antagonists; Tapentadol; Time Factors; Yohimbine | 2015 |
The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model.
Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Animals; Bupivacaine; Cells, Cultured; Dermatologic Surgical Procedures; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Hyperalgesia; Injections, Intraperitoneal; Male; Pain Measurement; Pain, Postoperative; Pituitary Gland; Rats, Sprague-Dawley; Sciatic Nerve; Sodium Channel Blockers; Sodium Channels; Thiophenes; Time Factors | 2015 |
The antidepressant drugs fluoxetine and duloxetine produce anxiolytic-like effects in a schedule-induced polydipsia paradigm in rats: enhancement of fluoxetine's effects by the α2 adrenoceptor antagonist yohimbine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Anti-Anxiety Agents; Antidepressive Agents; Disease Models, Animal; Drinking; Drinking Water; Duloxetine Hydrochloride; Fluoxetine; Food Deprivation; Male; Polydipsia; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Yohimbine | 2015 |
Specific alteration of rhythm in temperature-stressed rats possess features of abdominal pain in IBS patients.
Topics: Abdominal Pain; Animals; Carbolines; Cold Temperature; Disease Models, Animal; Duloxetine Hydrochloride; Irritable Bowel Syndrome; Male; Nociception; Rats, Sprague-Dawley; Stress, Physiological; Temperature; Visceral Pain | 2015 |
Prior stress exposure increases pain behaviors in a rat model of full thickness thermal injury.
Topics: Animals; Behavior, Animal; Burns; Disease Models, Animal; Duloxetine Hydrochloride; Hyperalgesia; Male; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Serotonin and Noradrenaline Reuptake Inhibitors; Stress, Psychological | 2015 |
The anti-inflammatory activity of duloxetine, a serotonin/norepinephrine reuptake inhibitor, prevents kainic acid-induced hippocampal neuronal death in mice.
Topics: Animals; Astrocytes; CA3 Region, Hippocampal; Cell Death; Disease Models, Animal; Duloxetine Hydrochloride; Excitatory Amino Acid Agonists; Interleukin-1beta; Kainic Acid; Male; Mice; Mice, Inbred ICR; Microglia; Neuroprotection; Serotonin and Noradrenaline Reuptake Inhibitors; Tumor Necrosis Factor-alpha | 2015 |
Central Sensitization and Neuropathic Features of Ongoing Pain in a Rat Model of Advanced Osteoarthritis.
Topics: Analgesics; Animals; Arthralgia; Central Nervous System Sensitization; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Hindlimb; Lidocaine; Male; Medulla Oblongata; Neuralgia; Osteoarthritis, Knee; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Spinal Cord | 2016 |
Effects of duloxetine on microRNA expression profile in frontal lobe and hippocampus in a mouse model of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Duloxetine Hydrochloride; Food Preferences; Frontal Lobe; Gene Expression Profiling; Gene Expression Regulation; Hippocampus; Male; Mice; MicroRNAs; Motor Activity; Oligonucleotide Array Sequence Analysis; Time Factors | 2015 |
Antidepressant-like Effects of ZBH2012001, a Novel Potent Serotonin and Norepinephrine Reuptake Inhibitor.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Benzodioxoles; Calcium; Cyclic AMP; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; HEK293 Cells; Helplessness, Learned; Hindlimb Suspension; Humans; Inhibitory Concentration 50; Locomotion; Male; Mice; Mice, Inbred ICR; Protein Binding; Rats; Rats, Sprague-Dawley; Serotonin and Noradrenaline Reuptake Inhibitors; Swimming; Thiophenes | 2016 |
Duloxetine prevents the effects of prenatal stress on depressive-like and anxiety-like behavior and hippocampal expression of pro-inflammatory cytokines in adult male offspring rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Anxiety; Body Weight; Cytokines; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Female; Gene Expression Regulation; Gestational Age; Hippocampus; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stress, Psychological; Swimming; Water Deprivation | 2016 |
Cooperative opioid and serotonergic mechanisms generate superior antidepressant-like effects in a mice model of depression.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Behavior, Animal; Codeine; Depression; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Duloxetine Hydrochloride; Enzyme Inhibitors; Hindlimb Suspension; Male; Mice; Motor Activity; Selective Serotonin Reuptake Inhibitors; Serotonin; Thiophenes; Tramadol | 2009 |
Comparison of mechanical allodynia and the affective component of inflammatory pain in rats.
Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Celecoxib; Central Nervous System Agents; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Escape Reaction; Fluoxetine; Inflammation; Male; Motor Activity; Neuropsychological Tests; Pain; Pain Measurement; Physical Stimulation; Pyrazoles; Rats; Rats, Sprague-Dawley; Scopolamine; Sulfonamides; Thiophenes; Treatment Outcome | 2010 |
Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594.
Topics: Amines; Analgesics; Animals; Azetidines; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Duloxetine Hydrochloride; Exploratory Behavior; Gabapentin; gamma-Aminobutyric Acid; Male; Mecamylamine; Morphine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Thiophenes | 2010 |
Long lasting pain hypersensitivity following ligation of the tendon of the masseter muscle in rats: a model of myogenic orofacial pain.
Topics: Adrenergic Uptake Inhibitors; Analgesics; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Facial Pain; Hyperalgesia; Ligation; Male; Masseter Muscle; Neuroglia; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tendons; Thiophenes; Trigeminal Nucleus, Spinal | 2010 |
Halothane-anesthetized rabbit: a new experimental model to test the effects of besipirdine and duloxetine on lower urinary tract function.
Topics: Anesthesia; Anesthetics; Animals; Atomoxetine Hydrochloride; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Electromyography; Female; Halothane; Humans; Indoles; Muscle, Smooth; Norepinephrine; Prazosin; Propylamines; Pyridines; Rabbits; Retrospective Studies; Thiophenes; Urinary Tract; Urinary Tract Infections; Urodynamics | 2011 |
Evidence for a differential opioidergic involvement in the analgesic effect of antidepressants: prediction for efficacy in animal models of neuropathic pain?
Topics: Analgesics; Animals; Antidepressive Agents; Clomipramine; Cyclopropanes; Diabetes Mellitus, Experimental; Disease Models, Animal; Duloxetine Hydrochloride; Hyperalgesia; Male; Milnacipran; Naloxone; Neuralgia; Rats; Rats, Sprague-Dawley; Thiophenes | 2011 |
Duloxetine use in painful conditions.
Topics: Analgesia; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Disease Models, Animal; Duloxetine Hydrochloride; Humans; Low Back Pain; Osteoarthritis; Pain; Retrospective Studies; Thiophenes; Treatment Outcome | 2011 |
Effects of milnacipran, duloxetine and indomethacin, in polyarthritic rats using the Randall-Selitto model.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Indomethacin; Male; Milnacipran; Rats; Rats, Wistar; Thiophenes | 2011 |
Gap junction dysfunction in the prefrontal cortex induces depressive-like behaviors in rats.
Topics: Analysis of Variance; Animals; Carbenoxolone; Connexin 43; Disease Models, Animal; Duloxetine Hydrochloride; Electroshock; Exploratory Behavior; Fluoxetine; Food Deprivation; Food Preferences; Gap Junctions; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hormone Antagonists; Inhibition, Psychological; Isoquinolines; Male; Microscopy, Electron, Transmission; Mifepristone; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Restraint, Physical; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Social Isolation; Stress, Psychological; Sucrose; Sweetening Agents; Swimming; Thiophenes | 2012 |
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Central Nervous System Stimulants; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Ibuprofen; Lameness, Animal; Male; Morphine; Motor Activity; Neuritis; Rats; Rats, Sprague-Dawley; Thiophenes | 2012 |
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Locomotion; Male; Morphine; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes | 2012 |
The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model.
Topics: Administration, Oral; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Morphine; Neuralgia; Neuroma; Pain Measurement; Pain Threshold; Pregabalin; Rats; Rats, Sprague-Dawley; Thiophenes; Time Factors | 2012 |
Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Drug Interactions; Duloxetine Hydrochloride; Etodolac; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mexiletine; Mice; Paclitaxel; Peripheral Nervous System Diseases; Pregabalin; Thiophenes; Tissue Distribution | 2012 |
Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats.
Topics: Amitriptyline; Animals; Anti-Ulcer Agents; Antidepressive Agents; Disease Models, Animal; Duloxetine Hydrochloride; Fluoxetine; Immersion; Indomethacin; Male; Mianserin; Mirtazapine; Rats; Rats, Sprague-Dawley; Reserpine; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Thiophenes; Water | 2012 |
Pharmacological validation of early and late phase of rat mono-iodoacetate model using the Tekscan system.
Topics: Alkylating Agents; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Chronic Disease; Dexamethasone; Dinoprostone; Disease Models, Animal; Duloxetine Hydrochloride; Hindlimb; Iodoacetates; Male; Morphine; Muscle Fibers, Skeletal; Naproxen; Neurons, Afferent; Pain Measurement; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Restraint, Physical; Synovial Fluid; Thiophenes; Weight-Bearing | 2013 |
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cyclohexanols; Cyclopropanes; Disease Models, Animal; Drug Therapy, Combination; Duloxetine Hydrochloride; Fluoxetine; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Male; Methyltyrosines; Milnacipran; Neuromuscular Junction; Norepinephrine; p-Chloroamphetamine; Pain; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin; Thiophenes; Venlafaxine Hydrochloride | 2004 |
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain.
Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopram; Disease Models, Animal; Duloxetine Hydrochloride; Male; Mianserin; Mirtazapine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes | 2005 |
Pharmacological validation of a model of cystitis pain in the mouse.
Topics: Analgesics; Animals; Behavior, Animal; Cyclophosphamide; Cystitis; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Ketorolac; Male; Mice; Morphine; Pain; Pain Measurement; Thiophenes | 2007 |
Dopamine D(1) and D(2) receptor agonism enhances antinociception mediated by the serotonin and noradrenaline reuptake inhibitor duloxetine in the rat formalin test.
Topics: Analgesics; Animals; Antidepressive Agents; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Formaldehyde; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Selective Serotonin Reuptake Inhibitors; Thiophenes; Time Factors | 2007 |
Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats.
Topics: Alcohol Deterrents; Animals; Behavior, Addictive; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Ethanol; Male; Naltrexone; Pyrimidines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Saccharin; Self Administration; Sweetening Agents; Thiophenes | 2008 |