dufulin and Prostatic-Neoplasms

dufulin has been researched along with Prostatic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for dufulin and Prostatic-Neoplasms

Article	Year
Synthesis, X-ray crystallographic analysis, and antitumor activity of N-(benzothiazole-2-yl)-1-(fluorophenyl)-O,O-dialkyl-alpha-aminophosphonates. Bioorganic & medicinal chemistry letters, 2006, Mar-15, Volume: 16, Issue:6 Alpha-aminophosphonates containing benzothiazole and fluorine moiety, 4a-4m, were synthesized by Mannich-type addition in ionic liquid media with high yield and short reaction time. Their structures were established by IR, (1)H NMR, (13)C NMR, and elemental analysis. The X-ray crystallographic data of compounds 4j and 4m were provided. The newly synthesized compounds were evaluated for their anticancer activities against PC3, A431, A375, and Bcap37 cells in vitro by the MTT method. Compound 4c is highly effective against PC3 cells and moderate to A431 cells. Hence, further study is necessary to find out the potential antitumor activities. Topics: Antineoplastic Agents; Benzothiazoles; Cell Proliferation; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Lung Neoplasms; Magnetic Resonance Spectroscopy; Male; Melanoma; Organophosphonates; Prohibitins; Prostatic Neoplasms; Skin Neoplasms; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured	2006

Article

Year

Synthesis, X-ray crystallographic analysis, and antitumor activity of N-(benzothiazole-2-yl)-1-(fluorophenyl)-O,O-dialkyl-alpha-aminophosphonates.

Bioorganic & medicinal chemistry letters, 2006, Mar-15, Volume: 16, Issue:6

Alpha-aminophosphonates containing benzothiazole and fluorine moiety, 4a-4m, were synthesized by Mannich-type addition in ionic liquid media with high yield and short reaction time. Their structures were established by IR, (1)H NMR, (13)C NMR, and elemental analysis. The X-ray crystallographic data of compounds 4j and 4m were provided. The newly synthesized compounds were evaluated for their anticancer activities against PC3, A431, A375, and Bcap37 cells in vitro by the MTT method. Compound 4c is highly effective against PC3 cells and moderate to A431 cells. Hence, further study is necessary to find out the potential antitumor activities.

Topics: Antineoplastic Agents; Benzothiazoles; Cell Proliferation; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Lung Neoplasms; Magnetic Resonance Spectroscopy; Male; Melanoma; Organophosphonates; Prohibitins; Prostatic Neoplasms; Skin Neoplasms; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured

2006