dsp 4 and Seizures
dsp 4 has been researched along with Seizures in 8 studies
DSP 4: RN given refers to parent cpd
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " In intact rats, bicuculline (a GABA-A antagonist, 118 pmol) microinfused into this area produced sporadic seizures, while in rats previously injected with DSP-4, bicuculline determined long-lasting self-sustaining status epilepticus." | 3.72 | A damage to locus coeruleus neurons converts sporadic seizures into self-sustaining limbic status epilepticus. ( Alessandrl, MG; Ferrucci, M; Fornai, F; Giorgi, FS; Lazzeri, G; Lenzi, P; Murri, L; Pizzanelli, C, 2003) |
| "Alzheimer's disease is a common age associated neurodegenerative disorder associated with an elevated risk of seizures that may be fundamentally connected to cognitive dysfunction." | 1.46 | Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques. ( Nuñez, A; Reyes-Marin, KE, 2017) |
| "These seizures are characterized by running/bouncing clonus and tonic extensor convulsions." | 1.29 | Role of norepinephrine in forebrain and brainstem seizures: chemical lesioning of locus ceruleus with DSP4. ( Bettendorf, AF; Browning, RA; Burger, RL; Jobe, PC; Mishra, PK, 1994) |
| "Haloperidol-induced catalepsy was potentiated in DSP-4 treated rats, while arecoline-induced catalepsy was attenuated." | 1.26 | Alterations in drug induced catalepsy and post-decapitation convulsions following brain and spinal cord depletion of norepinephrine by the neurotoxin DSP-4. ( Asin, KE; Fibiger, HC; Wirtshafter, D, 1982) |
Research
Studies (8)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Reyes-Marin, KE | 1 |
| Nuñez, A | 1 |
| Jahan, K | 1 |
| Pillai, KK | 1 |
| Vohora, D | 1 |
| Pericić, D | 1 |
| Svob, D | 1 |
| Giorgi, FS | 1 |
| Ferrucci, M | 1 |
| Lazzeri, G | 1 |
| Pizzanelli, C | 1 |
| Lenzi, P | 1 |
| Alessandrl, MG | 1 |
| Murri, L | 1 |
| Fornai, F | 1 |
| Asin, KE | 1 |
| Wirtshafter, D | 1 |
| Fibiger, HC | 1 |
| Mishra, PK | 1 |
| Burger, RL | 1 |
| Bettendorf, AF | 1 |
| Browning, RA | 1 |
| Jobe, PC | 1 |
| Trzaskowska, E | 1 |
| Puciłowski, O | 1 |
| Dyr, W | 1 |
| Kostowski, W | 1 |
| Hauptmann, M | 1 |
| Danysz, W | 1 |
| Jonsson, G | 1 |
| Mohammed, AK | 1 |
| Archer, T | 1 |
Other Studies
8 other studies available for dsp 4 and Seizures
| Article | Year |
|---|---|
Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques.
Topics: Alzheimer Disease; Animals; Benzylamines; Cerebral Cortex; Disease Models, Animal; Disease Susceptib | 2017 |
DSP-4 induced depletion of brain noradrenaline and increased 6-hertz psychomotor seizure susceptibility in mice is prevented by sodium valproate.
Topics: Animals; Anticonvulsants; Benzylamines; Brain; Disease Models, Animal; Disease Susceptibility; Drug | 2018 |
Interaction of stress and noradrenergic drugs in the control of picrotoxin-induced seizures.
Topics: Adrenergic Agents; Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Analysis of Variance; Animals | 2002 |
A damage to locus coeruleus neurons converts sporadic seizures into self-sustaining limbic status epilepticus.
Topics: Animals; Benzylamines; Bicuculline; Biogenic Monoamines; Cerebellum; Dopamine beta-Hydroxylase; Drug | 2003 |
Alterations in drug induced catalepsy and post-decapitation convulsions following brain and spinal cord depletion of norepinephrine by the neurotoxin DSP-4.
Topics: Amines; Animals; Arecoline; Benzylamines; Brain; Catalepsy; Drug Interactions; Haloperidol; Humans; | 1982 |
Role of norepinephrine in forebrain and brainstem seizures: chemical lesioning of locus ceruleus with DSP4.
Topics: Animals; Benzylamines; Brain Stem; Differential Threshold; Dose-Response Relationship, Drug; Female; | 1994 |
Suppression of ethanol tolerance and dependence in rats treated with DSP-4, a noradrenergic neurotoxin.
Topics: Alcoholism; Animals; Benzylamines; Brain; Drug Tolerance; Locus Coeruleus; Male; Motor Activity; Nor | 1986 |
The hindlimb extension reflex is not a reliable marker of post-decapitation convulsions or spinal noradrenaline depletion in rats.
Topics: Animals; Animals, Newborn; Benzylamines; Brain; Hindlimb; Hydroxydopamines; Locus Coeruleus; Male; N | 1985 |