Page last updated: 2024-10-26

dsp 4 and Seizures

dsp 4 has been researched along with Seizures in 8 studies

DSP 4: RN given refers to parent cpd

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
" In intact rats, bicuculline (a GABA-A antagonist, 118 pmol) microinfused into this area produced sporadic seizures, while in rats previously injected with DSP-4, bicuculline determined long-lasting self-sustaining status epilepticus."3.72A damage to locus coeruleus neurons converts sporadic seizures into self-sustaining limbic status epilepticus. ( Alessandrl, MG; Ferrucci, M; Fornai, F; Giorgi, FS; Lazzeri, G; Lenzi, P; Murri, L; Pizzanelli, C, 2003)
"Alzheimer's disease is a common age associated neurodegenerative disorder associated with an elevated risk of seizures that may be fundamentally connected to cognitive dysfunction."1.46Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques. ( Nuñez, A; Reyes-Marin, KE, 2017)
"These seizures are characterized by running/bouncing clonus and tonic extensor convulsions."1.29Role of norepinephrine in forebrain and brainstem seizures: chemical lesioning of locus ceruleus with DSP4. ( Bettendorf, AF; Browning, RA; Burger, RL; Jobe, PC; Mishra, PK, 1994)
"Haloperidol-induced catalepsy was potentiated in DSP-4 treated rats, while arecoline-induced catalepsy was attenuated."1.26Alterations in drug induced catalepsy and post-decapitation convulsions following brain and spinal cord depletion of norepinephrine by the neurotoxin DSP-4. ( Asin, KE; Fibiger, HC; Wirtshafter, D, 1982)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19903 (37.50)18.7374
1990's1 (12.50)18.2507
2000's2 (25.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Reyes-Marin, KE1
Nuñez, A1
Jahan, K1
Pillai, KK1
Vohora, D1
Pericić, D1
Svob, D1
Giorgi, FS1
Ferrucci, M1
Lazzeri, G1
Pizzanelli, C1
Lenzi, P1
Alessandrl, MG1
Murri, L1
Fornai, F1
Asin, KE1
Wirtshafter, D1
Fibiger, HC1
Mishra, PK1
Burger, RL1
Bettendorf, AF1
Browning, RA1
Jobe, PC1
Trzaskowska, E1
Puciłowski, O1
Dyr, W1
Kostowski, W1
Hauptmann, M1
Danysz, W1
Jonsson, G1
Mohammed, AK1
Archer, T1

Other Studies

8 other studies available for dsp 4 and Seizures

ArticleYear
Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques.
    Brain research, 2017, Dec-15, Volume: 1677

    Topics: Alzheimer Disease; Animals; Benzylamines; Cerebral Cortex; Disease Models, Animal; Disease Susceptib

2017
DSP-4 induced depletion of brain noradrenaline and increased 6-hertz psychomotor seizure susceptibility in mice is prevented by sodium valproate.
    Brain research bulletin, 2018, Volume: 142

    Topics: Animals; Anticonvulsants; Benzylamines; Brain; Disease Models, Animal; Disease Susceptibility; Drug

2018
Interaction of stress and noradrenergic drugs in the control of picrotoxin-induced seizures.
    Epilepsy research, 2002, Volume: 51, Issue:1-2

    Topics: Adrenergic Agents; Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Analysis of Variance; Animals

2002
A damage to locus coeruleus neurons converts sporadic seizures into self-sustaining limbic status epilepticus.
    The European journal of neuroscience, 2003, Volume: 17, Issue:12

    Topics: Animals; Benzylamines; Bicuculline; Biogenic Monoamines; Cerebellum; Dopamine beta-Hydroxylase; Drug

2003
Alterations in drug induced catalepsy and post-decapitation convulsions following brain and spinal cord depletion of norepinephrine by the neurotoxin DSP-4.
    Life sciences, 1982, May-03, Volume: 30, Issue:18

    Topics: Amines; Animals; Arecoline; Benzylamines; Brain; Catalepsy; Drug Interactions; Haloperidol; Humans;

1982
Role of norepinephrine in forebrain and brainstem seizures: chemical lesioning of locus ceruleus with DSP4.
    Experimental neurology, 1994, Volume: 125, Issue:1

    Topics: Animals; Benzylamines; Brain Stem; Differential Threshold; Dose-Response Relationship, Drug; Female;

1994
Suppression of ethanol tolerance and dependence in rats treated with DSP-4, a noradrenergic neurotoxin.
    Drug and alcohol dependence, 1986, Volume: 18, Issue:4

    Topics: Alcoholism; Animals; Benzylamines; Brain; Drug Tolerance; Locus Coeruleus; Male; Motor Activity; Nor

1986
The hindlimb extension reflex is not a reliable marker of post-decapitation convulsions or spinal noradrenaline depletion in rats.
    European journal of pharmacology, 1985, Oct-22, Volume: 116, Issue:3

    Topics: Animals; Animals, Newborn; Benzylamines; Brain; Hindlimb; Hydroxydopamines; Locus Coeruleus; Male; N

1985