dsp 4 has been researched along with Nerve Degeneration in 23 studies
DSP 4: RN given refers to parent cpd
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neuroinflammation is potentiated by early degeneration of the locus coeruleus noradrenergic pathway (LC-NE) commonly seen in aging-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease." | 1.46 | A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats. ( Bharani, KL; Derex, R; Granholm, AC; Ledreux, A, 2017) |
| "Behaviour was evaluated by catalepsy tests and activity box." | 1.32 | Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats. ( Schmidt, WJ; Srinivasan, J, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 8 (34.78) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Torrente, D | 1 |
| Su, EJ | 1 |
| Schielke, GP | 1 |
| Warnock, M | 1 |
| Mann, K | 1 |
| Lawrence, DA | 1 |
| Bharani, KL | 1 |
| Derex, R | 1 |
| Granholm, AC | 1 |
| Ledreux, A | 1 |
| Song, S | 2 |
| Jiang, L | 2 |
| Oyarzabal, EA | 1 |
| Wilson, B | 2 |
| Li, Z | 1 |
| Shih, YI | 2 |
| Wang, Q | 2 |
| Hong, JS | 2 |
| Oyarzabal, E | 1 |
| Riddick, NV | 1 |
| Moy, SS | 1 |
| Shin, E | 1 |
| Rogers, JT | 1 |
| Devoto, P | 1 |
| Björklund, A | 1 |
| Carta, M | 1 |
| Yao, N | 1 |
| Wu, Y | 1 |
| Zhou, Y | 1 |
| Ju, L | 1 |
| Liu, Y | 1 |
| Ju, R | 1 |
| Duan, D | 1 |
| Xu, Q | 1 |
| Szot, P | 1 |
| Miguelez, C | 1 |
| White, SS | 1 |
| Franklin, A | 1 |
| Sikkema, C | 1 |
| Wilkinson, CW | 1 |
| Ugedo, L | 1 |
| Raskind, MA | 1 |
| Jardanhazi-Kurutz, D | 1 |
| Kummer, MP | 1 |
| Terwel, D | 1 |
| Vogel, K | 1 |
| Dyrks, T | 1 |
| Thiele, A | 1 |
| Heneka, MT | 1 |
| Srinivasan, J | 1 |
| Schmidt, WJ | 1 |
| Kalinin, S | 1 |
| Feinstein, DL | 1 |
| Xu, HL | 1 |
| Huesa, G | 1 |
| Pelligrino, DA | 1 |
| Galea, E | 1 |
| Zhang, X | 2 |
| Zuo, DM | 2 |
| Yu, PH | 2 |
| Finnegan, KT | 1 |
| Verbanac, JS | 1 |
| Altman, HJ | 1 |
| Dhingra, P | 1 |
| Harrington, GM | 1 |
| Commissaris, RL | 1 |
| Davis, BA | 1 |
| Boulton, AA | 1 |
| Laporte, AM | 1 |
| Fattaccini, CM | 1 |
| Lombard, MC | 1 |
| Chauveau, J | 1 |
| Hamon, M | 1 |
| Campbell, DB | 1 |
| North, JB | 1 |
| Hess, EJ | 1 |
| Puoliväli, J | 1 |
| Pradier, L | 1 |
| Riekkinen, P | 1 |
| Charifi, C | 1 |
| Paut-Pagano, L | 1 |
| Debilly, G | 1 |
| Cespuglio, R | 1 |
| Jouvet, M | 1 |
| Valatx, JL | 1 |
| Zarei, M | 1 |
| Stephenson, JD | 1 |
| Ammar, AA | 1 |
| Södersten, P | 1 |
| Johnson, AE | 1 |
| Fritschy, JM | 3 |
| Grzanna, R | 3 |
| Berger, U | 1 |
| Geffard, M | 1 |
1 review available for dsp 4 and Nerve Degeneration
| Article | Year |
|---|---|
Selective effects of DSP-4 on locus coeruleus axons: are there pharmacologically different types of noradrenergic axons in the central nervous system?
Topics: Adrenergic Agents; Adrenergic Fibers; Axons; Benzylamines; Cerebral Cortex; Dopamine beta-Hydroxylas | 1991 |
22 other studies available for dsp 4 and Nerve Degeneration
| Article | Year |
|---|---|
Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity.
Topics: alpha-Synuclein; Animals; Dopaminergic Neurons; Humans; Mice; Nerve Degeneration; Neuroinflammatory | 2023 |
A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats.
Topics: Aging; Analysis of Variance; Animals; Astrocytes; Benzylamines; Brain-Derived Neurotrophic Factor; C | 2017 |
Loss of Brain Norepinephrine Elicits Neuroinflammation-Mediated Oxidative Injury and Selective Caudo-Rostral Neurodegeneration.
Topics: Animals; Benzylamines; Brain; Disease Progression; Dopaminergic Neurons; Gliosis; Inflammation; Lipo | 2019 |
Noradrenergic dysfunction accelerates LPS-elicited inflammation-related ascending sequential neurodegeneration and deficits in non-motor/motor functions.
Topics: Adrenergic Neurons; Aging; Animals; Benzylamines; Brain; Disease Models, Animal; Dopaminergic Neuron | 2019 |
Noradrenaline neuron degeneration contributes to motor impairments and development of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Adrenergic Neurons; Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Benz | 2014 |
Lesion of the locus coeruleus aggravates dopaminergic neuron degeneration by modulating microglial function in mouse models of Parkinson׳s disease.
Topics: Adrenergic Agents; Animals; Benzylamines; Calcium-Binding Proteins; Cells, Cultured; Coculture Techn | 2015 |
A comprehensive analysis of the effect of DSP4 on the locus coeruleus noradrenergic system in the rat.
Topics: Action Potentials; Animals; Benzylamines; Binding Sites; Disease Models, Animal; Down-Regulation; Lo | 2010 |
Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits.
Topics: Aging; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Behavior, Animal; Benzylamines; Cogniti | 2010 |
Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Behavior, Animal; Benzylamines; Cataleps | 2003 |
Degeneration of noradrenergic fibres from the locus coeruleus causes tight-junction disorganisation in the rat brain.
Topics: Animals; Autoantigens; Benzylamines; Blotting, Western; Brain; Cell Count; Chromatography, High Pres | 2006 |
Neuroprotection by R(-)-deprenyl and N-2-hexyl-N-methylpropargylamine on DSP-4, a neurotoxin, induced degeneration of noradrenergic neurons in the rat locus coeruleus.
Topics: Adrenergic Agents; Animals; Benzylamines; Locus Coeruleus; Male; Nerve Degeneration; Neurons; Norepi | 1995 |
Neurotoxins and monoamine oxidase inhibition: new aspects.
Topics: Animals; Benzylamines; Brain; Dose-Response Relationship, Drug; Isoenzymes; Male; Mice; Mice, Inbred | 1993 |
Conflict behavior in Maudsley reactive and nonreactive rats: effects of noradrenergic neuronal destruction.
Topics: Animals; Anxiety; Behavior, Animal; Benzylamines; Brain; Conflict, Psychological; Emotions; Female; | 1993 |
Immunohistochemical evidence of neuroprotection by R(-)-deprenyl and N-(2-hexyl)-N-methylpropargylamine on DSP-4-induced degeneration of rat brain noradrenergic axons and terminals.
Topics: Animals; Axons; Benzylamines; Immunohistochemistry; Male; Monoamine Oxidase Inhibitors; Nerve Degene | 1996 |
Effects of dorsal rhizotomy and selective lesion of serotonergic and noradrenergic systems on 5-HT1A, 5-HT1B, and 5-HT3 receptors in the rat spinal cord.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Benzamide | 1995 |
Tottering mouse motor dysfunction is abolished on the Purkinje cell degeneration (pcd) mutant background.
Topics: Animals; Benzylamines; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium | 1999 |
Impaired recovery of noradrenaline levels in apolipoprotein E-deficient mice after N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine lesion.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Apolipoproteins E; Benzylamines; Cerebellum; Choli | 2000 |
Effect of noradrenergic denervation of the amygdala upon recovery after sleep deprivation in the rat.
Topics: Adrenergic Agents; Amygdala; Animals; Benzylamines; Denervation; Locus Coeruleus; Male; Nerve Degene | 2000 |
Transhemispheric cortical reorganization in rat SmI and involvement of central noradrenergic system.
Topics: Animals; Benzylamines; Denervation; Electric Stimulation; Evoked Potentials, Somatosensory; Hindlimb | 2000 |
Locus coeruleus noradrenergic lesions attenuate intraoral intake.
Topics: Adrenergic Agents; Animals; Appetite Regulation; Benzylamines; Body Weight; Denervation; Dietary Suc | 2001 |
Degeneration of rat locus coeruleus neurons is not accompanied by an irreversible loss of ascending projections. Evidence for reestablishment of forebrain innervation by surviving neurons.
Topics: Afferent Pathways; Animals; Axons; Benzylamines; Brain; Cell Survival; Locus Coeruleus; Nerve Degene | 1992 |
Acute action of DSP-4 on central norepinephrine axons: biochemical and immunohistochemical evidence for differential effects.
Topics: Animals; Axons; Benzylamines; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; Hyp | 1989 |