dsp 4 has been researched along with Disease Models, Animal in 34 studies
DSP 4: RN given refers to parent cpd
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of the present study is to investigate the effects of single and simultaneous lesions of the noradrenergic and serotonergic pathways (NA-X, 5-HT-X and XX, respectively) by intracerebroventricular administration of selective neurotoxins N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine-HCl (DSP-4) and 5,7-dihydroxytryptamine (5,7-DHT) on anxiety-like behavior in rats." | 3.76 | Effects of single and simultaneous lesions of serotonergic and noradrenergic pathways on open-space and bright-space anxiety-like behavior in two animal models. ( Kompagne, H; Kuki, Z; Lévay, G; Markó, B; Nagy, KM; Sziray, N, 2010) |
| "A lesion of the noradrenergic nucleus Locus Coeruleus (LC) converts sporadic seizures evoked by microinfusion of bicuculline into the anterior piriform cortex (APC) of rats into limbic status epilepticus (SE)." | 3.73 | Locus coeruleus and neuronal plasticity in a model of focal limbic epilepsy. ( Blandini, F; Fornai, F; Giorgi, FS; Mauceli, G; Murri, L; Paparelli, A; Ruggieri, S, 2006) |
| "The effect of inositol as an antidepressant was previously demonstrated in both animal models of depression-like behavior and in clinical trials." | 3.71 | The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors. ( Belmaker, RH; Bourin, M; Clenet, F; Einat, H; Shaldubina, A, 2001) |
| "Given the clinical association between migraine, sleep-wake regulation, and fatigue, we sought to determine whether LC modulation could impact migraine-related phenotypes in several validated preclinical models of migraine." | 1.51 | Divergent influences of the locus coeruleus on migraine pathophysiology. ( Goadsby, PJ; Holland, PR; Kefel, M; Strother, LC; Vila-Pueyo, M, 2019) |
| "Alzheimer's disease is a common age associated neurodegenerative disorder associated with an elevated risk of seizures that may be fundamentally connected to cognitive dysfunction." | 1.46 | Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques. ( Nuñez, A; Reyes-Marin, KE, 2017) |
| "The treatment with methylphenidate had no beneficial effect on the rats' performance regardless of the DSP4 treatment." | 1.46 | Effects of methylphenidate on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4). ( Hauser, J; Lange, KW; Reissmann, A; Sontag, TA; Tucha, O, 2017) |
| "Previous findings suggest that neuropathic pain induces characteristic changes in the noradrenergic system that may modify the sensorial and affective dimensions of pain." | 1.43 | Effect of DSP4 and desipramine in the sensorial and affective component of neuropathic pain in rats. ( Berrocoso, E; Bravo, L; Camarena-Delgado, C; Mico, JA; Rey-Brea, R, 2016) |
| "BACKGROUND AND PURPOSE Parkinson's disease (PD) is characterized by progressive dopaminergic cell loss; however, the noradrenergic system exhibits degeneration as well." | 1.38 | Exendin-4 reverts behavioural and neurochemical dysfunction in a pre-motor rodent model of Parkinson's disease with noradrenergic deficit. ( Giordano, G; Harkavyi, A; Lever, R; Rampersaud, N; Whitton, J; Whitton, P, 2012) |
| "Using the rat model of parkinsonism with an additional noradrenergic degeneration induced by the N-(-2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) toxin we evaluated whether the circling motor activity and dose-failure episodes induced by levodopa (L-DOPA) differ between single (6-OHDA) and double (6-OHDA + DSP-4) denervated animals challenged with a single daily dose of L-DOPA." | 1.35 | Noradrenergic modulation of the motor response induced by long-term levodopa administration in Parkinsonian rats. ( Barbanoj, M; Gich, I; Kulisevsky, J; Pérez, V; Rodríguez-Alvarez, J; Rubio, A; Sosti, V, 2009) |
| "To determine whether coloboma mice exhibit other signs of ADHD, we assessed latent inhibition as a test of attention, and impulsivity in a delayed reinforcement paradigm." | 1.34 | Abnormal latent inhibition and impulsivity in coloboma mice, a model of ADHD. ( Bruno, KJ; Egami, K; Freet, CS; Grigson, PS; Hess, EJ; Twining, RC, 2007) |
| "Behaviour was evaluated by catalepsy tests and activity box." | 1.32 | Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats. ( Schmidt, WJ; Srinivasan, J, 2003) |
| "Dopaminergic lesion produced catalepsy and hypoactivity." | 1.32 | Behavioral and neurochemical effects of noradrenergic depletions with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine in 6-hydroxydopamine-induced rat model of Parkinson's disease. ( Schmidt, WJ; Srinivasan, J, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.88) | 18.2507 |
| 2000's | 10 (29.41) | 29.6817 |
| 2010's | 22 (64.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Reyes-Marin, KE | 1 |
| Nuñez, A | 1 |
| Jahan, K | 1 |
| Pillai, KK | 1 |
| Vohora, D | 1 |
| Vila-Pueyo, M | 1 |
| Strother, LC | 1 |
| Kefel, M | 1 |
| Goadsby, PJ | 1 |
| Holland, PR | 1 |
| Song, S | 1 |
| Wang, Q | 1 |
| Jiang, L | 1 |
| Oyarzabal, E | 1 |
| Riddick, NV | 1 |
| Wilson, B | 1 |
| Moy, SS | 1 |
| Shih, YI | 1 |
| Hong, JS | 1 |
| Shin, E | 1 |
| Rogers, JT | 1 |
| Devoto, P | 1 |
| Björklund, A | 1 |
| Carta, M | 1 |
| Wang, Y | 2 |
| Wang, HS | 1 |
| Wang, T | 2 |
| Huang, C | 2 |
| Liu, J | 2 |
| Chen, X | 1 |
| Sun, YN | 1 |
| Han, LN | 1 |
| Li, LB | 1 |
| Zhang, L | 1 |
| Wu, ZH | 1 |
| Fox, ME | 1 |
| Studebaker, RI | 1 |
| Swofford, NJ | 1 |
| Wightman, RM | 1 |
| Grimonprez, A | 1 |
| Raedt, R | 1 |
| Portelli, J | 1 |
| Dauwe, I | 1 |
| Larsen, LE | 1 |
| Bouckaert, C | 1 |
| Delbeke, J | 1 |
| Carrette, E | 1 |
| Meurs, A | 1 |
| De Herdt, V | 1 |
| Boon, P | 1 |
| Vonck, K | 1 |
| Yao, N | 1 |
| Wu, Y | 1 |
| Zhou, Y | 1 |
| Ju, L | 1 |
| Liu, Y | 1 |
| Ju, R | 1 |
| Duan, D | 1 |
| Xu, Q | 1 |
| Ledreux, A | 1 |
| Boger, HA | 1 |
| Hinson, VK | 1 |
| Cantwell, K | 1 |
| Granholm, AC | 1 |
| Bravo, L | 1 |
| Mico, JA | 1 |
| Rey-Brea, R | 1 |
| Camarena-Delgado, C | 1 |
| Berrocoso, E | 1 |
| Cao, LF | 1 |
| Peng, XY | 1 |
| Huang, Y | 1 |
| Wang, B | 1 |
| Zhou, FM | 1 |
| Cheng, RX | 1 |
| Chen, LH | 1 |
| Luo, WF | 1 |
| Liu, T | 1 |
| Hauser, J | 1 |
| Reissmann, A | 1 |
| Sontag, TA | 1 |
| Tucha, O | 1 |
| Lange, KW | 1 |
| Pérez, V | 1 |
| Sosti, V | 1 |
| Rubio, A | 1 |
| Barbanoj, M | 1 |
| Gich, I | 1 |
| Rodríguez-Alvarez, J | 1 |
| Kulisevsky, J | 1 |
| Hamani, C | 1 |
| Diwan, M | 1 |
| Macedo, CE | 1 |
| Brandão, ML | 1 |
| Shumake, J | 1 |
| Gonzalez-Lima, F | 1 |
| Raymond, R | 1 |
| Lozano, AM | 1 |
| Fletcher, PJ | 1 |
| Nobrega, JN | 1 |
| Biezonski, DK | 1 |
| Meyer, JS | 1 |
| Szot, P | 1 |
| Miguelez, C | 1 |
| White, SS | 1 |
| Franklin, A | 1 |
| Sikkema, C | 1 |
| Wilkinson, CW | 1 |
| Ugedo, L | 1 |
| Raskind, MA | 1 |
| Sziray, N | 1 |
| Kuki, Z | 1 |
| Nagy, KM | 1 |
| Markó, B | 1 |
| Kompagne, H | 1 |
| Lévay, G | 1 |
| Kudo, T | 4 |
| Kushikata, T | 2 |
| Kudo, M | 2 |
| Hirota, K | 2 |
| Rampersaud, N | 1 |
| Harkavyi, A | 1 |
| Giordano, G | 1 |
| Lever, R | 1 |
| Whitton, J | 1 |
| Whitton, P | 1 |
| Lapiz, MD | 1 |
| Fulford, A | 1 |
| Muchimapura, S | 1 |
| Mason, R | 1 |
| Parker, T | 1 |
| Marsden, CA | 1 |
| Srinivasan, J | 2 |
| Schmidt, WJ | 2 |
| Wenk, GL | 1 |
| McGann, K | 1 |
| Hauss-Wegrzyniak, B | 1 |
| Rosi, S | 1 |
| Kalinin, S | 1 |
| Gavrilyuk, V | 1 |
| Polak, PE | 1 |
| Vasser, R | 1 |
| Zhao, J | 1 |
| Heneka, MT | 1 |
| Feinstein, DL | 1 |
| Bruno, KJ | 1 |
| Freet, CS | 1 |
| Twining, RC | 1 |
| Egami, K | 1 |
| Grigson, PS | 1 |
| Hess, EJ | 1 |
| Giorgi, FS | 1 |
| Mauceli, G | 1 |
| Blandini, F | 1 |
| Ruggieri, S | 1 |
| Paparelli, A | 1 |
| Murri, L | 1 |
| Fornai, F | 1 |
| Windle, V | 1 |
| Power, A | 1 |
| Corbett, D | 1 |
| Culić, M | 1 |
| Saponjić, J | 1 |
| Janković, B | 1 |
| Udović, S | 1 |
| Popović, S | 1 |
| Rakić, L | 1 |
| Einat, H | 1 |
| Clenet, F | 1 |
| Shaldubina, A | 1 |
| Belmaker, RH | 1 |
| Bourin, M | 1 |
| Santucci, AC | 1 |
| Haroutunian, V | 1 |
| Davis, KL | 1 |
34 other studies available for dsp 4 and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques.
Topics: Alzheimer Disease; Animals; Benzylamines; Cerebral Cortex; Disease Models, Animal; Disease Susceptib | 2017 |
DSP-4 induced depletion of brain noradrenaline and increased 6-hertz psychomotor seizure susceptibility in mice is prevented by sodium valproate.
Topics: Animals; Anticonvulsants; Benzylamines; Brain; Disease Models, Animal; Disease Susceptibility; Drug | 2018 |
Divergent influences of the locus coeruleus on migraine pathophysiology.
Topics: Animals; Benzylamines; Cortical Spreading Depression; Disease Models, Animal; Dopamine beta-Hydroxyl | 2019 |
Noradrenergic dysfunction accelerates LPS-elicited inflammation-related ascending sequential neurodegeneration and deficits in non-motor/motor functions.
Topics: Adrenergic Neurons; Aging; Animals; Benzylamines; Brain; Disease Models, Animal; Dopaminergic Neuron | 2019 |
Noradrenaline neuron degeneration contributes to motor impairments and development of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Adrenergic Neurons; Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Benz | 2014 |
L-DOPA-induced dyskinesia in a rat model of Parkinson's disease is associated with the fluctuational release of norepinephrine in the sensorimotor striatum.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Benzylamines; Chromatography, High Pressure Liquid | 2014 |
Additional noradrenergic depletion aggravates forelimb akinesia and abnormal subthalamic nucleus activity in a rat model of Parkinson's disease.
Topics: Action Potentials; Animals; Benzylamines; Disease Models, Animal; Dopamine; Forelimb; Male; Norepine | 2014 |
Stress and Drug Dependence Differentially Modulate Norepinephrine Signaling in Animals with Varied HPA Axis Function.
Topics: Analysis of Variance; Animals; Benzylamines; Disease Models, Animal; Hypothalamo-Hypophyseal System; | 2015 |
The antidepressant-like effect of vagus nerve stimulation is mediated through the locus coeruleus.
Topics: Animals; Benzylamines; Depression; Disease Models, Animal; Dopamine beta-Hydroxylase; Exploratory Be | 2015 |
Lesion of the locus coeruleus aggravates dopaminergic neuron degeneration by modulating microglial function in mouse models of Parkinson׳s disease.
Topics: Adrenergic Agents; Animals; Benzylamines; Calcium-Binding Proteins; Cells, Cultured; Coculture Techn | 2015 |
BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson׳s disease.
Topics: Animals; Behavior, Animal; Benzylamines; Brain; Brain-Derived Neurotrophic Factor; Chaperonin 60; Co | 2016 |
Effect of DSP4 and desipramine in the sensorial and affective component of neuropathic pain in rats.
Topics: Adrenergic Agents; Adrenergic Uptake Inhibitors; Analgesics; Animals; Antidepressive Agents; Avoidan | 2016 |
Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson's Disease.
Topics: Animals; Benzylamines; Corpus Striatum; Disease Models, Animal; Levodopa; Male; Norepinephrine; Oxid | 2016 |
Effects of methylphenidate on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4).
Topics: Animals; Attention; Attention Deficit Disorder with Hyperactivity; Benzylamines; Central Nervous Sys | 2017 |
Noradrenergic modulation of the motor response induced by long-term levodopa administration in Parkinsonian rats.
Topics: Animals; Antiparkinson Agents; Benzylamines; Brain; Disease Models, Animal; Dopamine; Dose-Response | 2009 |
Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats.
Topics: 5,7-Dihydroxytryptamine; Adrenergic Agents; Analysis of Variance; Animals; Benzylamines; Catheter Ab | 2010 |
Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity.
Topics: 5,7-Dihydroxytryptamine; Animals; Area Under Curve; Benzylamines; Brain; Central Nervous System Stim | 2010 |
A comprehensive analysis of the effect of DSP4 on the locus coeruleus noradrenergic system in the rat.
Topics: Action Potentials; Animals; Benzylamines; Binding Sites; Disease Models, Animal; Down-Regulation; Lo | 2010 |
Effects of single and simultaneous lesions of serotonergic and noradrenergic pathways on open-space and bright-space anxiety-like behavior in two animal models.
Topics: 5,7-Dihydroxytryptamine; Adaptation, Physiological; Adrenergic Agents; Adrenergic Uptake Inhibitors; | 2010 |
A central neuropathic pain model by DSP-4 induced lesion of noradrenergic neurons: preliminary report.
Topics: Animals; Benzylamines; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Locus Coerul | 2010 |
Antinociceptive effects of neurotropin in a rat model of central neuropathic pain: DSP-4 induced noradrenergic lesion.
Topics: 5,7-Dihydroxytryptamine; Adrenergic Agents; Analgesics; Animals; Area Under Curve; Benzylamines; Dis | 2011 |
Exendin-4 reverts behavioural and neurochemical dysfunction in a pre-motor rodent model of Parkinson's disease with noradrenergic deficit.
Topics: Animals; Behavior, Animal; Benzylamines; Cerebrum; Disease Models, Animal; Dopamine; Exenatide; Male | 2012 |
Influence of postweaning social isolation in the rat on brain development, conditioned behavior, and neurotransmission.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Adrenergic Agents; Amphetamine; Analysis | 2003 |
Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Behavior, Animal; Benzylamines; Cataleps | 2003 |
The toxicity of tumor necrosis factor-alpha upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Basal Nucleus of Meynert; Benzylamines; Cell Count; Choline O-Acetyltran | 2003 |
Behavioral and neurochemical effects of noradrenergic depletions with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine in 6-hydroxydopamine-induced rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Amphetamine; Analysis of Variance; Animals; Basal | 2004 |
Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Benzylamines; Brain; C | 2007 |
Abnormal latent inhibition and impulsivity in coloboma mice, a model of ADHD.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Benzylamines; Brain Chemistry; Chromatograph | 2007 |
Locus coeruleus and neuronal plasticity in a model of focal limbic epilepsy.
Topics: Animals; Benzylamines; Bicuculline; Cerebral Cortex; Disease Models, Animal; Epilepsies, Partial; Li | 2006 |
Norepinephrine depletion facilitates recovery of function after focal ischemia in the rat.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzylamines; Brain Infarction; Disease Models, Ani | 2007 |
Effect of neurotoxin DSP4 on EEG power spectra in the rat acute model of epilepsy.
Topics: Adrenergic Agents; Animals; Benzylamines; Disease Models, Animal; Electroencephalography; Epilepsy; | 1995 |
The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors.
Topics: Animals; Antidepressive Agents; Benzylamines; Depression; Disease Models, Animal; Drug Interactions; | 2001 |
Pharmacological alleviation of combined cholinergic/noradrenergic lesion-induced memory deficits in rats.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Benzylamines; Cholinergic Agents; Cholinergic Fibers | 1991 |